Effects of the fruit essential oil of Cuminum cyminum Linn. (Apiaceae) on acquisition and expression of morphine tolerance and dependence in mice

Haghparast, Abbas; Shams, Jamal; Khatibi, Ali; Alizadeh, Amir-Mohammad; Kamalinejad, Mohammad

doi:10.1016/j.neulet.2008.05.060

Cited by 19 publications

(12 citation statements)

References 21 publications

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“…It should be mentioned that solely a FEO injection did not show any analgesic effects. However, these findings justified the conclusion that the VO of C. cyminum L. may improve morphine tolerance and dependence in mice …”

Section: Analgesic Actionsupporting

confidence: 60%

“…As mentioned before, morphine tolerance is a serious problem during treatment with opioids. Haghparast et al tried to identify the influence of fruit essential oil (FEO) of Cuminum cyminum L. (Apiaceae) on the development and expression of morphine tolerance and dependence in mice. Thus, morphine was injected three times daily for 3 days.…”

Section: Analgesic Actionmentioning

confidence: 99%

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Actions of essential oils on the central nervous system: An updated review.

2011

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The administration of essential oils or their constituents in aromatherapy, complementary medicine, and folk medicine has been known for a long time, and its relevance is steadily growing. In the last few years, many scientific studies were conducted to investigate the effect and the mechanisms of action of these compounds on the central nervous system. The aim of this article is to summarize the literature on this topic published in the period 2008-2010, upgrading a comprehensive review. The major actions discussed are pain, anxiety, learning, memory, attention, arousal, relaxation, sedation and sleep. Furthermore, the effects on mood, behaviour and perception as well as the application of essential oils in the treatment of epilepsy, stress, dementia and Alzheimer's disease are discussed.

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Section: Analgesic Actionsupporting

confidence: 60%

Section: Analgesic Actionmentioning

confidence: 99%

Actions of essential oils on the central nervous system: An updated review.

2011

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“…The morphine dependence was also reversed in a dose-dependent manner as evaluated by decreased conditioning scores (the acquisition and expression of morphine-induced conditioned place preference) in mice. [122123] Anti-epileptic activity of cumin oil is documented. It decreased the frequency of spontaneous activity induced by pentylenetetrazol (PTZ).…”

Section: Biological and Pharmacological Activitymentioning

confidence: 99%

Cuminum cyminum and Carum carvi: An update

2011

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Cuminum cyminum and Carum carvi are the sources of cumin and caraway seeds respectively, which have been used since antiquity for the treatment of various indications in traditional healing systems in wide geographical areas. Cumin and caraway seeds are rich sources of essential oils and have been actively researched for their chemical composition and biological activities. In recent times (especially during the last 3 years) considerable progress has been made regarding validation of their acclaimed medicinal attributes by extensive experimental studies. In this attempt many novel bioactivities have been revealed. This review highlights the significance of cumin and caraway as potential source of diverse natural products and their medicinal applications.

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“…Intraperitoneal administration of Cumin FEO (0.001%, 0.01%, 0.1%, 0.5%, 1% and 2%; 5 ml/kg) or Tween-80 (0.5%, 5 ml/kg) did not show any conditioning effects. Administration of Cumin FEO (0.001-2%, 5 ml/kg; ip), 60 min before test on day 5 (expression) decreased the conditioning scores at the doses of 1% and 2% while ip injection of Cumin FEO (0.001-2%, 5 ml/kg), 60 min before morphine injection (5mg/kg, sc) during 3 days of conditioning session (acquisition) significantly resulted in decrement of rewarding properties of morphine at the doses of 0.1%, 0.5%, 1% and 2% in dose-dependent manner [127].…”

Section: Cuminum Cyminummentioning

confidence: 94%