Effects of the Homozygous Minute-Iv Deficiency on the Development of Drosophila Melanogaster

Farnsworth, M. W.

doi:10.1093/genetics/42.1.7

Cited by 15 publications

(3 citation statements)

References 9 publications

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“…Indeed, the possibility of embryonic development in the absence of embryonically produced ribosomes arises from early 20th century studies in Xenopus embryos seemingly lacked nucleoli but had smaller nuclear blobs (Wallace, 1960). Similarly, a majority of Drosophila minute homozygotes develop as first instar larvae-despite the presence of homozygous minutes that are also embryonic lethalsuggesting a potential for extensive embryonic development in the absence of zygotic RPs (Brehme, 1939;Farnsworth, 1957aFarnsworth, , 1957b. Some of the limitations in drawing conclusions from these earlier observations are: (1) the presence of residual rDNA copies, (2) generalized defects in the early mutant homozygotes, with overall lack of vitality in anucleolate Xenopus embryos (Steele et al, 1984;Wallace, 1960), and a small and sluggish character of Drosophila minute homozygotes (Brehme, 1939;Farnsworth, 1957aFarnsworth, , 1957b.…”

Section: Discussionmentioning

confidence: 99%

Maternal Ribosomes Are Sufficient for Tissue Diversification during Embryonic Development in C. elegans

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Maternal Ribosomes Are Sufficient for Tissue Diversification during Embryonic Development in C. elegans

et al. 2019

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“…In addition to having a smaller body as a result of their smaller cell size, Minute animals display delayed larval development, short bristles and recessive lethality. Other manifestations of Minute include large and rough eyes as well as reduced viability and fertility [36][37][38][39][40][41]. Several Minute mutant animals exhibit alterations in the wing structure, weaker legs, paler body colour and chromosome elimination in somatic cells [41,42].…”

Section: Drosophilamentioning

confidence: 99%

Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism growth and the connecting signalling pathways

Surya

Cenik

2022

Open Biol.

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Translation machinery is responsible for the production of cellular proteins; thus, cells devote the majority of their resources to ribosome biogenesis and protein synthesis. Single-copy loss of function in the translation machinery components results in rare ribosomopathy disorders, such as Diamond–Blackfan anaemia in humans and similar developmental defects in various model organisms. Somatic copy number alterations of translation machinery components are also observed in specific tumours. The organism-wide response to haploinsufficient loss-of-function mutations in ribosomal proteins or translation machinery components is complex: variations in translation machinery lead to reduced ribosome biogenesis, protein translation and altered protein homeostasis and cellular signalling pathways. Cells are affected both autonomously and non-autonomously by changes in translation machinery or ribosome biogenesis through cell–cell interactions and secreted hormones. We first briefly introduce the model organisms where mutants or knockdowns of protein synthesis and ribosome biogenesis are characterized. Next, we specifically describe observations in Caenorhabditis elegans and Drosophila melanogaster , where insufficient protein synthesis in a subset of cells triggers cell non-autonomous growth or apoptosis responses that affect nearby cells and tissues. We then cover the characterized signalling pathways that interact with ribosome biogenesis/protein synthesis machinery with an emphasis on their respective functions during organism development.

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“…Despite Farnsworth (1951) indicating M(4)101 mutations are embryonic lethals, Hochman (1973) found that among the progeny of M/+ heterozygote parents, M(4)101 57g and Df( 4)M( 4)101-63a homozygotes died, not as embryos but as larvae. Therefore, to examine M( 4)101 homozygotes, we collected eggs from M/+ parents and assayed them with the expectation that, on average, 25% would be of the genotype M/M.…”

Section: A Ribosomal Protein S3a Genementioning

confidence: 99%

Analysis of Two Cosmid Clones from Chromosome 4 of Drosophila melanogaster Reveals Two New Genes Amid an Unusual Arrangement of Repeated Sequences

Locke¹,

Podemski²,

Roy³

et al. 1999

Genome Res.

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Chromosome 4 from Drosophila melanogaster has several unusual features that distinguish it from the other chromosomes. These include a diffuse appearance in salivary gland polytene chromosomes, an absence of recombination, and the variegated expression of P-element transgenes. As part of a larger project to understand these properties, we are assembling a physical map of this chromosome. Here we report the sequence of two cosmids representing ∼5% of the polytenized region. Both cosmid clones contain numerous repeated DNA sequences, as identified by cross hybridization with labeled genomic DNA, BLAST searches, and dot matrix analysis, which are positioned between and within the transcribed sequences. The repetitive sequences include three copies of the mobile element Hoppel, one copy of the mobile element HB, and 18 DINE repeats. DINE is a novel, short repeated sequence dispersed throughout both cosmid sequences. One cosmid includes the previously described cubitus interruptus(ci) gene and two new genes: that a gene with a predicted amino acid sequence similar to ribosomal protein S3a which is consistent with the Minute(4)101 locus thought to be in the region, and a novel member of the protein family that includes plexin and met–hepatocyte growth factor receptor. The other cosmid contains only the two short 5′-most exons from thezinc-finger-homolog-2 (zfh-2) gene. This is the first extensive sequence analysis of noncoding DNA from chromosome 4. The distribution of the various repeats suggests its organization is similar to the β-heterochromatic regions near the base of the major chromosome arms. Such a pattern may account for the diffuse banding of the polytene chromosome 4 and the variegation of many P-element transgenes on the chromosome.

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Effects of the Homozygous Minute-Iv Deficiency on the Development of Drosophila Melanogaster

Cited by 15 publications

References 9 publications

Maternal Ribosomes Are Sufficient for Tissue Diversification during Embryonic Development in C. elegans

Maternal Ribosomes Are Sufficient for Tissue Diversification during Embryonic Development in C. elegans

Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism growth and the connecting signalling pathways

Analysis of Two Cosmid Clones from Chromosome 4 of Drosophila melanogaster Reveals Two New Genes Amid an Unusual Arrangement of Repeated Sequences

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