Effects of the ketogenic diet on nutritional status, resting energy expenditure, and substrate oxidation in patients with medically refractory epilepsy: A 6-month prospective observational study

Tagliabue, Anna; Bertoli, Simona; Trentani, Claudia; Borrelli, Paola; Veggiotti, Pierangelo

doi:10.1016/j.clnu.2011.09.012

Cited by 76 publications

(67 citation statements)

References 17 publications

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“…After 12 wk, weight gain is similar in both groups of mice. Long-term use of KD in children with epilepsy resulted in slowed growth but did not change the body mass index (17,28,39). In rats it has been shown that 4 -6 wk KD leads to visceral fat accumulation (32) and increased leptin LONG-TERM KETOGENIC DIET REDUCES ␤-AND ␣-CELL MASS concentrations (10).…”

Section: Discussionmentioning

confidence: 99%

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

Ellenbroek

Dijck

Töns

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

126

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Ellenbroek JH, van Dijck L, Töns HA, Rabelink TJ, Carlotti F, Ballieux BE, de Koning EJ. Long-term ketogenic diet causes glucose intolerance and reduced ␤-and ␣-cell mass but no weight loss in mice. Am J Physiol Endocrinol Metab 306: E552-E558, 2014. First published January 7, 2014 doi:10.1152/ajpendo.00453.2013.-High-fat, low-carbohydrate ketogenic diets (KD) are used for weight loss and for treatment of refractory epilepsy. Recently, short-time studies in rodents have shown that, besides their beneficial effect on body weight, KD lead to glucose intolerance and insulin resistance. However, the long-term effects on pancreatic endocrine cells are unknown. In this study we investigate the effects of long-term KD on glucose tolerance and ␤-and ␣-cell mass in mice. Despite an initial weight loss, KD did not result in weight loss after 22 wk. Plasma markers associated with dyslipidemia and inflammation (cholesterol, triglycerides, leptin, monocyte chemotactic protein-1, IL-1␤, and IL-6) were increased, and KD-fed mice showed signs of hepatic steatosis after 22 wk of diet. Long-term KD resulted in glucose intolerance that was associated with insufficient insulin secretion from ␤-cells. After 22 wk, insulin-stimulated glucose uptake was reduced. A reduction in ␤-cell mass was observed in KD-fed mice together with an increased number of smaller islets. Also ␣-cell mass was markedly decreased, resulting in a lower ␣-to ␤-cell ratio. Our data show that long-term KD causes dyslipidemia, a proinflammatory state, signs of hepatic steatosis, glucose intolerance, and a reduction in ␤-and ␣-cell mass, but no weight loss. This indicates that long-term high-fat, lowcarbohydrate KD lead to features that are also associated with the metabolic syndrome and an increased risk for type 2 diabetes in humans. pancreatic islet; ketogenic diet; glucose intolerance; ␤-cell; ␣-cell

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Section: Discussionmentioning

confidence: 99%

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

Ellenbroek

Dijck

Töns

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

126

View full text Add to dashboard Cite

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“…[24][25][26] Con respecto al efecto que la dieta ejerce sobre el crecimiento, los últimos reportes indican que, con aporte calórico y proteico adecuados, se logra un ritmo de crecimiento normal. 27,28 En cada consulta, los datos de antropometría se evalúan y comparan con los patrones de crecimiento recomendados por la Sociedad Argentina de Pediatría. 29 Las complicaciones a largo plazo no han sido aún sistemáticamente revisadas.…”

Section: Efectos Adversos a Corto Y Largo Plazounclassified

Recomendaciones para el manejo clínico pediátrico de la dieta cetogénica en el tratamiento de la epilepsia refractaria

Alberti

Agustinho

Argumedo³

et al. 2016

Arch Argent Pediat

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“…During the study period, participants maintained a constant foods supply, without changing their usual eating habits. *** FIGURE 1 HERE*** Fingertip capillary blood samples were collected in the fasted state and after 15,30,45,60,90, and 120 min after starting to eat, changing the finger each time to avoid traumatization of the skin. The puncture was performed with the lancet Accu-Check Safe-T-Pro Plus (Roche Diagnostics, Basel, Switzerland) and blood was collected directly and immediately analysed using test strip Reflotron ® Glucose.…”

Section: Methodsmentioning

confidence: 99%

“…12 During a VLCKD it is mandatory to maintain a low level of glycemia (about 80-90 mg/dL) to avoid insulin spikes 13 . This condition allows subjects to improve their fat oxidation as demonstrated by Paoli et al 14 and by Tagliabue et al 15 Another important aspect of a VLCKD is the influence of such dietary regime on the perception of hunger. 16 It has been suggested that ketone bodies reduce hunger through different and complex mechanisms 17 ; on the other side it is known that post prandial glucose and insuline spikes, tipically produced after the intake of traditional ultra-processed products which usually show a high glycemic index (GI) 5 elicit food craving and overeating, with a preference for high-GI carbohydrates 18 , a phenomenon defined as the CHO-craving effect.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Different High-Protein Low-Carbohydrates Proprietary Foods on Blood Sugar in Healthy Subjects

Lodi

Karsten

Bosco

et al. 2016

Journal of Medicinal Food

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The aim of our work was to analyze the effects on blood sugar through the calculation of the glycemic score (GS) of 10 different high-protein-low-carbohydrates proprietary foods which are commonly used as meals during very low carbohydrate ketogenic diet or during low carbohydrate diet. 14 healthy female tested the glycemic response curve elicited by 1000 Kj of glucose three times within 3 weeks period (1 test each week) compared to each of the 10 test-foods once on separate days twice a week. After determining the GS of each food in each individual, the mean GS of each test food was calculated. All test foods, compared to glucose, produced a significantly lower glycemic response . The GS of all test foods resulted lower than 25 and the difference between the mean glycemia after the intake of glucose (mean 122 ±15 mg/dl) and after the intake of the sweet test foods (mean 89 ± 7 mg/dl) was of 33 mg/dl (P<0.001), whereas that after the intake of glucose and the savory test foods (mean 91 ± 8 mg/dl ) was of 31mg/dl (P<0.001). We can conclude that the reformulation of ultra-processed ready-to-consume foods in a low carbohydrate, high protein version can produce a significant low glycemic response while maintaining the valued ready-to-use format and high palatability demanded by consumers. The low impact on postprandial glycemia and the nutritional characteristics of these proprietary foods make them useful both in weight control and in diabetes care dietary management.

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Effects of the ketogenic diet on nutritional status, resting energy expenditure, and substrate oxidation in patients with medically refractory epilepsy: A 6-month prospective observational study

Cited by 76 publications

References 17 publications

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

Recomendaciones para el manejo clínico pediátrico de la dieta cetogénica en el tratamiento de la epilepsia refractaria

The Effects of Different High-Protein Low-Carbohydrates Proprietary Foods on Blood Sugar in Healthy Subjects

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