Effects of the loss of maternal gut microbiota before pregnancy on gut microbiota, food allergy susceptibility, and epigenetic modification on subsequent generations

Aizawa, Shinta; Uebanso, Takashi; Shimohata, Takaaki; Mawatari, Kazuaki; Takahashi, Akira

doi:10.12938/bmfh.2022-093

Cited by 4 publications

References 59 publications

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Maternal influences on offspring food allergy

Lee,

Nazmul,

Lan

et al. 2024

Immunological Reviews

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SummaryThe prevalence of allergies has been globally escalating. While allergies could appear at any age, they often develop in early life. However, the significant knowledge gap in the field is the mechanisms by which allergies affect certain people but not others. Investigating early factors and events in neonatal life that have a lasting impact on determining the susceptibilities of children to develop allergies is a significant area of the investigation as it promotes the understanding of neonatal immune system that mediates tolerance versus allergies. This review focuses on the research over the recent 10 years regarding the potential maternal factors that influence offspring allergies with a view to food allergy, a potentially life‐threatening cause of anaphylaxis. The role of breast milk, maternal diet, maternal antibodies, and microbiota that have been suggested as key maternal factors regulating offspring allergies are discussed here. We also suggest future research area to expand our knowledge of maternal–offspring interactions on the pathogenesis of food allergy.

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Maternal influences on offspring food allergy

Lee,

Nazmul,

Lan

et al. 2024

Immunological Reviews

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Characteristics of the effects of Polygonati Rhizoma on gut microbiota and metabolites in vitro associated with poor dietary habits in pregnant women

Xu,

Li,

Hong

et al. 2024

PLoS ONE

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Poor dietary habits have been associated with dysbiosis and microbial imbalance in pregnant women. Such imbalances can pose health risks during pregnancy. This study aimed to explore the impact of Polygonati Rhizoma on the gut microbiota of pregnant women through In vitro simulated fermentation. Interestingly, significant differences in microbial community richness and structure were found between the control and the treatment with Polygonati Rhizoma. Analysis of composition and variability indicated that the treatment with Polygonati Rhizoma group showed higher levels of Lactobacillus and Bifidobacterium, but lower levels of Parabacteroides and Lachnoclostridium. The study also investigated specific genera differences between groups using the co-occurrence network analysis and their correlations with microbial metabolites by the redundancy analysis (RDA), Mantel-test network heatmap, and heatmap highlighting the relationships among gut microbiota, short-chain fatty acids (SCFAs), and gases in the absence or presence of Polygonati Rhizoma supplementation. Functional predictions from BugBase phenotype prediction indicated changes in potentially pathogenic and aerobic bacteria in Polygonati Rhizoma supplementation. Overall, the findings provide valuable insights into the influence of Polygonati Rhizoma on the gut microbiota in pregnant women associated with poor dietary habits.

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Preconception maternal gut dysbiosis affects enteric nervous system development and disease susceptibility in offspring

Duan,

Zhang,

Chen

et al. 2024

Preprint

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Maternal health, specifically changes in the gut microbiota, profoundly affects the health of offspring. However, our understanding of how gut microbiota alterations during preconception period influence their offspring remains limited. In this study, we are dedicated to investigate the impact of preconception maternal gut microbiota disturbance on offspring enteric nervous system (ENS) development in mice and explore the underlying mechanisms. Through in vivo and in vitro experiments, we made a novel discovery that preconception maternal exposure to antibiotics before pregnant leads abnormal development of the offspring’s ENS, increasing their susceptibility to water avoidance stress. Supported by metagenomic, targeted metabolome, and transcriptome analysis, we identified that preconception antibiotic exposure disrupts the expression of genes crucial for embryonic ENS development by altering the composition of the maternal gut microbiota. Furthermore, our multi-omics analysis combined with Limosilactobacillus reuteri (L. reuteri) gestational supplementation illustrated that maternal gut microbiota and metabolites influence embryonic ENS development via the propionate-GPR41-GDNF/RET/SOX10 signaling pathway. Our findings highlight the critical importance of maintaining a healthy maternal gut microbiota during the preconception period for proper ENS development in offspring.

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Effects of the loss of maternal gut microbiota before pregnancy on gut microbiota, food allergy susceptibility, and epigenetic modification on subsequent generations

Abstract: TitleEffects of the loss of maternal gut microbiota before pregnancy on gut microbiota, food allergy susceptibility, and epigenetic modification on subsequent generations

Cited by 4 publications

References 59 publications

Maternal influences on offspring food allergy

Maternal influences on offspring food allergy

Characteristics of the effects of Polygonati Rhizoma on gut microbiota and metabolites in vitro associated with poor dietary habits in pregnant women

Preconception maternal gut dysbiosis affects enteric nervous system development and disease susceptibility in offspring

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