Effects of the Methyl Donors Supplementation on Hippocampal Oxidative Stress, Depression and Anxiety in Chronically High Fructose-treated Rats

Maternal monosaccharide diets evoke cognitive, locomotor, and emotional disturbances in adolescent and young adult offspring rats

“…In addition to sucrose, consumption of 30%, but not 15%, of FRU solution (w/v) for 9 weeks decreased the time spent in the open arms of the EPM in adult (at PND152) Swiss mice of both sexes ( 22 ). Likewise, chronic 18 weeks of FRU (23% w/v) feeding caused reduced entries and time spent in open arms of EPM ( 24 ), and preadolescent (at PND92) but not adult (at PND132) male rats fed a 55% high-FRU diet for 8–10 weeks reduced the time spent in the open arms of the EPM ( 19 ). Interestingly, 8 weeks of FRU supplementation in HFD (17% w/w) and water (10%) was sufficient to decrease the number of entries in OFT in male Wistar rats ( 73 ).…”

“…Several studies have demonstrated the association between postnatal HSD (mainly fructose) intake and a reduction in struggling and floating time with increasing immobile time. For instance, female Wistar rats treated with 23% FRU for 18 weeks showed increased immobility time ( 24 ). Likewise, a 55% high-FRU diet for 10 weeks evoked greater immobility time correlated with an increase in blood corticosterone measured after a 10-min FST in rats (at PND 116–120) of both sexes ( 77 ).…”

“…Although several preclinical studies have evaluated the effects of maternal HSD on offspring behavior ( 15 – 18 ), most of these studies were performed using male or female rodents independently. It is also worth adding that most preclinical studies have focused on the relationship between postnatal HSD consumption and behavioral disturbances ( 19 – 24 ). However, maternal diet in the prenatal period also plays a crucial role in offspring neurodevelopmental disorders ( 25 – 27 ).…”