Effects of the NMDA antagonist MK-801 on radial maze performance in histidine-deficient rats

Nishiga, Miyuki; Sugimoto, Yukihiko; Taga, Chiyomi; Fujii, Yoko; Kamei, Chiaki

doi:10.1016/s0024-3205(02)01504-7

Cited by 13 publications

(5 citation statements)

References 19 publications

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“…Similar to clozapine (Addy and Levin 2002;Addy et al 2005;Levin and Christopher 2006), pyrilamine impaired working memory in intact rats, and previous RAM studies with pyrilamine in rats have found working memory impairments (Chen et al 2001;Nishiga et al 2002a;Nishiga et al 2002b;Taga et al 2001). In addition, intrahippocampal administration of pyrilamine impaired memory on the three-panel runway task (Nakazato et al 2000).…”

Section: Pyrilamine and Nicotine Interactions On Working Memory On Thmentioning

confidence: 66%

“…Thus, the decrease in reference memory errors observed with pyrilamine was not due to decreased opportunities to make reference memory errors. Studies in another laboratory have reported increased reference memory errors in rats given pyrilamine (Nishiga et al 2002a;Nishiga et al 2002b;Taga et al 2001). Those studies evaluated reference memory using an 8-arm RAM with only 4 of the arms baited.…”

Section: Pyrilamine Effects On Reference Memorymentioning

confidence: 99%

“…Those studies evaluated reference memory using an 8-arm RAM with only 4 of the arms baited. In addition, they trained their rats until they reached a criterion of at most 1 error per trial for five successive trials, which according to one paper took 36 days of training (Nishiga et al 2002b). In comparison, our rats received only 18 training sessions on the more difficult 16-arm RAM prior to the pyrilamine sessions.…”

Section: Pyrilamine Effects On Reference Memorymentioning

confidence: 99%

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Histamine H1 receptor involvement in prepulse inhibition and memory function: Relevance for the antipsychotic actions of clozapine

Roegge¹,

Perraut²,

Xin³

et al. 2007

Pharmacology Biochemistry and Behavior

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Histamine H(1) blockade is one of the more prominent actions of the multi-receptor acting antipsychotic clozapine. It is currently not known how much this H(1) antagonism of clozapine contributes to the therapeutic or adverse side effects of clozapine. The current studies with Sprague-Dawley rats were conducted to determine the participation of histaminergic H(1) receptor subtype in sensorimotor plasticity and memory function affected by clozapine using tests of prepulse inhibition (PPI) and radial-arm maze choice accuracy. The PPI impairment caused by the glutamate antagonist dizocilpine (MK-801) was significantly attenuated by clozapine. In the current project, we found that the selective H(1) antagonist pyrilamine also reversed the dizocilpine-induced impairment in PPI of tactile startle with an auditory prepulse. In the radial-arm maze (RAM), pyrilamine, like clozapine, impaired working memory and caused a significant dose-related slowing of response. Pyrilamine, however, decreased the number of reference memory errors. We have previously shown that nicotine effectively attenuates the clozapine-induced working memory impairment, but in the current study, nicotine did not significantly alter the effects of pyrilamine on the RAM. In summary, the therapeutic effect of clozapine in reversing PPI impairment was mimicked by the H(1) antagonist pyrilamine, while pyrilamine had a mixed effect on cognition. Pyrilamine impaired working memory but improved reference memory in rats. Thus, H(1) antagonism seems to play a role in part of the beneficial actions of antipsychotics, such as clozapine.

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Section: Pyrilamine and Nicotine Interactions On Working Memory On Thmentioning

confidence: 66%

Section: Pyrilamine Effects On Reference Memorymentioning

confidence: 99%

Section: Pyrilamine Effects On Reference Memorymentioning

confidence: 99%

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Histamine H1 receptor involvement in prepulse inhibition and memory function: Relevance for the antipsychotic actions of clozapine

Roegge¹,

Perraut²,

Xin³

et al. 2007

Pharmacology Biochemistry and Behavior

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“…Also, other studies concerning the histaminergic system and memory demonstrated learning and memory impairment when histamine was administered [2,15,47]. Nishiga et al [20] showed that rats on a histidine-deficient diet exhibited reduced hippocampal histamine contents and improved eight-arm radial maze performance. The results of a study by Liu et al [19], which used histidine decarboxylase knockout mice, indicated that a lack of histamine improves fear conditioning consolidation.…”

Section: Discussionmentioning

confidence: 98%

Microinjection of histamine into the cerebellar vermis impairs emotional memory consolidation in mice

Gianlorenço

Canto-de-Souza

Mattioli

2011

Brain Research Bulletin

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The biogenic amine histamine is an important neurotransmitter in the central nervous system that has been implicated in learning and memory processes. Experimental evidence indicates that the role of the cerebellum may be more complex than the simple regulation of motor responses, and recent studies have demonstrated significant involvement of the cerebellum in emotional memory consolidation. This study investigated the effect of histamine microinjected into the cerebellar vermis on emotional memory consolidation in mice in the elevated plus-maze (EPM). The cerebellar vermis of male mice (Swiss Albino) were implanted with guide cannulae. The mice weighed between 25 and 30 g. After three days of recovery, behavioral tests in the EPM were performed on two consecutive days; the testing periods were called, Trial 1 and Trial 2. Immediately after Trial 1, the animals received microinjections of histamine in the cerebellar vermis (0.54, 1.36, 2.72, and 4.07 nmol/0.1 μl). On both days, the test sessions were recorded to enable analysis of behavioral measures. The decrease in open arm exploration (% entries and % time spent in the open arms) in Trial 2 relative to Trial 1 was used as a measure of learning and memory. The data were analyzed using One-way Analysis of Variance (ANOVA) and Duncan's tests. The percentage of open arm entries (%OAE) and the percentage of time spent in the open arms (%OAT) were reduced in Trial 2 relative to Trial 1 for the control group; the same was true for the group that was microinjected with histamine at doses of 0.54 (%OAE and %OAT) and 1.36 nmol (%OAT). However, when the animals received histamine at doses of 2.72 and 4.07 nmol, their open arm exploration did not decrease. No significant changes were observed in the number of enclosed arm entries (EAE), an EPM index of general exploratory activity. These results suggest that there is a dose-dependent inhibitory effect of histamine microinjected into the cerebellar vermis on emotional memory consolidation.

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“…The procedure was as follows (Isayama et al 2001;Taga et al 2001;Nishiga et al 2002). To familiarize them with the radial maze, animals received one daily habituation session for 3 days prior to training.…”

Section: Animalsmentioning

confidence: 99%

Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats

Nishiga

Kamei

2003

Psychopharmacology

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Effects of the NMDA antagonist MK-801 on radial maze performance in histidine-deficient rats

Cited by 13 publications

References 19 publications

Histamine H1 receptor involvement in prepulse inhibition and memory function: Relevance for the antipsychotic actions of clozapine

Histamine H1 receptor involvement in prepulse inhibition and memory function: Relevance for the antipsychotic actions of clozapine

Microinjection of histamine into the cerebellar vermis impairs emotional memory consolidation in mice

Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats

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