Effects of the oral administration of silver nanoparticles on wound healing in male rats

Samiee-Rad, Fatemeh; Sofiabadi, Mohammad; Habibian, Zoheir; Gheibi, Nematollah

doi:10.33235/wpr.28.1.8-16

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…The sections were blindly interpreted by an expert pathologist for the presence of angiogenesis and inflammatory cells (neutrophils, eosinophils, and mast cells), and fibroblasts using Iwf-Iox-Holland ocular lens. [ 8 ] Toluidine blue staining was also conducted for detecting mast cells.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…Nowadays, tissue engineering, growth factors therapy, nanobiotechnologic and biologic-based treatments have been widely introduced to accelerate the WH process. [ 5 6 7 8 9 10 ] However, these new therapeutic approaches are very expensive and limited. For a long time, humans have found that the plants, soil, and their derivatives are effective in WH.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of healing effects of poultice containing 0.5% fulvic acid on male white-male rats with skin ulcer

Samiee-Rad¹,

Sedighi²,

Taherkhani³

et al. 2022

J Cutan Aesthet Surg

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Background: Chronic and acute skin wounds are an important health concern because they are very frequent during human life and affect millions of people worldwide. Shortening the wound healing process reduces treatment costs and hospitalization. Therefore, researchers have been looking for new treatment approaches to shorten the wound healing process. Aims and Objectives: The aim of this study was to evaluate the wound healing properties of poultice containing 0.5% fulvic acid. Materials and Methods: In this experimental study, a full-thickness skin wound was created on the dorsal side of 24 male rats. The animals were then randomly assigned to control, sham, and experiment groups. The skin defects were daily bandaged by using sterile gauze dipped in normal saline, carboxymethylcellulose, and 0.5% fulvic acid for 21 days, respectively. The wound healing rate was evaluated grossly and histologically at various time intervals post injury. Both descriptive and statistical analysis methods were applied ( P < 0.05). Results: The wound healing percentage was significantly higher in the poultice treatment group at all time intervals ( P < 0.001). The wound was completely closed in this group compared with other groups at the end of week 4 post treatment. The mean numbers of inflammatory cells were statistically lower, and fibroblasts and vessels were higher in the poultice group than in the other groups at various time intervals post injury ( P < 0.001). Conclusion: Fulvic acid (0.5%) could be used as an effective therapeutic approach to improve the wound healing process because of its unique anti-inflammatory and neovascularization properties at the skin wound site.

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Section: Aterials and M Ethodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of healing effects of poultice containing 0.5% fulvic acid on male white-male rats with skin ulcer

Samiee-Rad¹,

Sedighi²,

Taherkhani³

et al. 2022

J Cutan Aesthet Surg

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Advances in nano silver-based biomaterials and their biomedical applications

Babu,

Tirkey,

Paul

et al. 2024

Engineered Regeneration

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The effect of topical 0.5% humic acid gel on male rats with skin ulcer

Samiee-Rad,

Ghasemi,

Bahadoran

et al. 2024

JCAS

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Background Humic derivatives have antibacterial and anti-inflammatory properties. Aim This study aimed to assess the experimental wound-healing effect of 0.5% humic acid gel. Materials and Methods A full-thickness skin wound was created on the dorsal side of 24 Sprague Dawley male rats (220–250g). The animals were then randomly divided into the control, sham, and experimental groups. Skin wounds were bandaged daily using sterile gauze dipped in normal saline, carboxymethylcellulose, and 0.5% humic acid for 21 days. The wound-healing rate was evaluated grossly and histologically at various time intervals post-injury. Results Wound-healing percentage was significantly higher in the gel treatment group at all time points (P < 0.05). The mean number of inflammatory cells was significantly lower in the humic acid gel group than in the other groups (P < 0.001). Moreover, the number of new vascular cells and fibroblasts were significantly increased in the humic acid gel compared to the control (P < 0.001). Conclusion These data confirmed that 0.5% humic acid gel accelerates wound healing, probably by anti-inflammatory effects, as well as by promoting vascular and fibroblast proliferation. Therefore, the humic acid gel may be used to improve wound care.

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Effects of the oral administration of silver nanoparticles on wound healing in male rats

Abstract: For referencing Samiee-Rad F et al. Effects of the oral administration of silver nanoparticles on wound healing in male rats.

Cited by 3 publications

References 27 publications

Evaluation of healing effects of poultice containing 0.5% fulvic acid on male white-male rats with skin ulcer

Evaluation of healing effects of poultice containing 0.5% fulvic acid on male white-male rats with skin ulcer

Advances in nano silver-based biomaterials and their biomedical applications

The effect of topical 0.5% humic acid gel on male rats with skin ulcer

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