Effects of the PI3K/Akt/HO-1 pathway on autophagy in a sepsis-induced acute lung injury mouse model

Tian, Jing; Li, Yanan; Mao, Xing; Xie, Keliang; Zheng, Yuxin; Yu, Yang; Yu, Yonghao

doi:10.1016/j.intimp.2023.111063

Cited by 8 publications

(2 citation statements)

References 41 publications

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“…Our results revealed that inhibition of autophagy might contribute to reducing inflammatory responses. However, in contrast to our results, overexpression of HO-1 has been reported to enhance autophagy, thereby alleviating the level of inflammation [ 34 ]. In our study, autophagy was elevated in the ALI models and accompanied by changes in pathology and inflammation, which were reversed by 3-MA.…”

Section: Discussioncontrasting

confidence: 99%

3-methyladenine ameliorates acute lung injury by inhibiting oxidative damage and apoptosis

Lei,

Liu,

et al. 2024

Heliyon

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Section: Discussioncontrasting

confidence: 99%

3-methyladenine ameliorates acute lung injury by inhibiting oxidative damage and apoptosis

Lei,

Liu,

et al. 2024

Heliyon

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“…The findings reveal that dihydropashanone dramatically increases the expression of HO-1 in BV2 and HT22 cells. To verify whether dihydropashanone exerts antioxidant effects by regulating HO-1 expression, SnPP (HO-1 inhibitor) was used [ 36 ]. The findings indicate that SnPP inhibited the positive effects of dihydropashanone in BV2 and HT22 cells.…”

Section: Discussionmentioning

confidence: 99%

Dihydropashanone Isolated from Lindera erythrocarpa, a Potential Natural Product for the Treatment of Neurodegenerative Diseases

Liu,

Yoon,

Lee

et al. 2024

IJMS

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Lindera erythrocarpa, a flowering plant native to eastern Asia, has been reported to have neuroprotective activity. However, reports on the specific bioactive compounds in L. erythrocarpa are finite. The aim of this study was to investigate the anti-neuroinflammatory and neuroprotective effects of the compounds isolated from L. erythrocarpa. Dihydropashanone, a compound isolated from L. erythrocarpa extract, was found to have protected mouse hippocampus HT22 cells from glutamate-induced cell death. The antioxidant and anti-inflammatory properties of dihydropashanone in mouse microglial BV2 and HT22 cells were explored in this study. The results reveal that dihydropashanone inhibits lipopolysaccharide-induced inflammatory response and suppresses the activation of nuclear factor (NF)-κB in BV2 cells. In addition, dihydropashanone reduced the buildup of reactive oxygen species in HT22 cells and induced activation of the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase (HO)-1 signaling pathway in BV2 and HT22 cells. Our results suggest that dihydropashanone reduces neuroinflammation by decreasing NF-κB activation in microglia cells and protects neurons from oxidative stress via the activation of the Nrf2/HO-1 pathway. Thus, our data suggest that dihydropashanone offers a broad range of applications in the treatment of neurodegenerative illnesses.

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HO‐1: An emerging target in fibrosis

Lu,

Liu,

Ren

et al. 2024

Journal Cellular Physiology

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Fibrosis, an aberrant reparative response to tissue injury, involves a disruption in the equilibrium between the synthesis and degradation of the extracellular matrix, leading to its excessive accumulation within normal tissues, and culminating in organ dysfunction. Manifesting in the terminal stages of nearly all chronic ailments, fibrosis carries a high mortality rate and poses a significant threat to human health. Heme oxygenase‐1 (HO‐1) emerges as an endogenous protective agent, mitigating tissue damage through its antioxidant, anti‐inflammatory, and antiapoptotic properties. Numerous studies have corroborated HO‐1's potential as a therapeutic target in anti‐fibrosis treatment. This review delves into the structural and functional attributes, and the upstream and downstream pathways of HO‐1. Additionally, the regulatory networks and mechanisms of HO‐1 in cells associated with fibrosis are elucidated. The role of HO‐1 in various fibrosis‐related diseases is also explored. Collectively, this comprehensive information serves as a foundation for future research and augments the viability of HO‐1 as a therapeutic target for fibrosis.

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Effects of the PI3K/Akt/HO-1 pathway on autophagy in a sepsis-induced acute lung injury mouse model

Cited by 8 publications

References 41 publications

3-methyladenine ameliorates acute lung injury by inhibiting oxidative damage and apoptosis

3-methyladenine ameliorates acute lung injury by inhibiting oxidative damage and apoptosis

Dihydropashanone Isolated from Lindera erythrocarpa, a Potential Natural Product for the Treatment of Neurodegenerative Diseases

HO‐1: An emerging target in fibrosis

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