Effects of the Potassium and Magnesium Salts of Aspartic Acid on Metabolic Exhaustion

Rosen, Harry; Blumenthal, Albert; Agersborg, H. P. K.

doi:10.1002/jps.2600510623

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…It is clear from these results that the administration of aspartic acid salts has had no effect on the endurance capacity of the subjects studied. This is in contrast to earlier reports, which found that treatment with salts of aspartic acid was effective in improving the work tolerance of rats (14,21) and men (1). Neither Matoush et al (15) in a study using rats and dogs, nor Consolazio et al 6and 1-lagan et al (8) studying humans, found any effect of aspartate administration on physical performance, in agreement with the present results.…”

Section: Discussionsupporting

confidence: 78%

“…Ths treatment was also effective in causing an increased endurance capacity in these animals. Similar results have been produced by Rosen et al (21) and Kendrik et al (11).…”

Section: Introductionsupporting

confidence: 91%

“…This may explain some of the apparent discrepancies in the literature, as sonic investigators have administered aspartate orally whereas others have used an intraperitoneal injection ill animals. There are, however, a number of reports that suggest that the oral route is effective in promoting an increased work capacity ill rats (2,21) and in man (1). The reason for theSC discrepancies is not at present clear.…”

Section: Discussionmentioning

confidence: 98%

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The Effects of Oral Administration of Salts of Aspartic Acid on the Metabolic Response to Prolonged Exhausting Exercise in Man

Maughan¹,

Sadler²

1983

Int J Sports Med

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The effects of the oral administration of salts of aspartic acid on endurance capacity and metabolic responses to prolonged bicycle exercise have been investigated. Previous reports in man and in animals have suggested that this treatment can increase the capacity to perform muscular work by virtue of its effect on circulating ammonia levels. Eight healthy young male subjects exercised to exhaustion on a bicycle ergometer at a work load requiring approximately 75% of maximum oxygen uptake. This work test was performed after placebo administration or after ingestion of 6 g of potassium-magnesium aspartate over a 24-h period, using a double-blind protocol. Exhaustion was reached after 82.7 +/- 23.5 min (mean +/- SD) following aspartate treatment and after 85.4 +/- 26.5 min following the placebo. No differences in the blood glucose, lactate, or ammonia concentrations or in the plasma free fatty acid concentration between the two treatments were observed. The respiratory exchange ratio was the same on both occasions. These results show no beneficial effect of oral aspartate administration on work capacity in man and also suggest that the metabolic processes that occur during exercise are not influenced by this treatment.

show abstract

Section: Discussionsupporting

confidence: 78%

“…Ths treatment was also effective in causing an increased endurance capacity in these animals. Similar results have been produced by Rosen et al (21) and Kendrik et al (11).…”

Section: Introductionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 98%

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The Effects of Oral Administration of Salts of Aspartic Acid on the Metabolic Response to Prolonged Exhausting Exercise in Man

Maughan¹,

Sadler²

1983

Int J Sports Med

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“…Enhanced exercise performance has been reported after acute administration of potassium (K) and magnesium (Mg) aspartate (Asp) in rats (15) and man (1,7,12,18) and after prolonged, daily consumption in man (10). However, other investigations in rats and dogs (9) and man (4) suggest that the ergogenic benefits of acute and prolonged administration of K ÷ Mg Asp are nonexistent.…”

Section: Introductionmentioning

confidence: 99%

“…These investigators suggested that K+Mg Asp did not affect the TCA cycle, but plays an important role in repolarization by actively transporting K+ across the muscle membrane.Administration of K + Mg Asp to rats and man within 24 th of physical exercise has been reported to increase exercise performance time. In rats, Rosen et al(15) reported that…”

mentioning

confidence: 99%

Absence of Effect of Potassium-Magnesium Aspartate on Physiologic Responses to Prolonged Work in Aerobically Trained Men

Rd¹,

Sj²,

Jj³

et al. 1982

Int J Sports Med

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The effects of oral administration of potassium and magnesium aspartate (K + Mg Asp) on physiologic responses to 90 min of treadmill walking at approximately 62% VO2 max were evaluated in seven healthy males (VO2 max = 59.5 ml X kg-1 X min-1). A total of 7.2 g of K + Mg Asp were administered to each subject during a 24 h period prior to work and compared to control and placebo trials. For control, placebo, and K + Mg Asp trials, no significant differences were observed in resting or exercise values for ventilation (VE), oxygen uptake (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RO), heart rate (HR), or blood pressure (BP). In addition, there were no differences between the three trials for exercise-induced decreases in body weight and increases in rectal temperature, or for pre- and post-exercise alterations in serum lactic acid, creatine kinase, lactic dehydrogenase, and percentage change in plasma volume. The findings from this study indicate that oral ingestion of K+ Mg Asp prior to exercise had no effect on cardiorespiratory, hematologic, and metabolic responses to 90 min of work conducted at approximately 62% VO2 max.

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Effects of potassium-aspartate salt administration on glycogen use in the rat during a swimming stress

Trudeau

Murphy

1993

Physiology & Behavior

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Effects of the Potassium and Magnesium Salts of Aspartic Acid on Metabolic Exhaustion

Cited by 10 publications

References 7 publications

The Effects of Oral Administration of Salts of Aspartic Acid on the Metabolic Response to Prolonged Exhausting Exercise in Man

The Effects of Oral Administration of Salts of Aspartic Acid on the Metabolic Response to Prolonged Exhausting Exercise in Man

Absence of Effect of Potassium-Magnesium Aspartate on Physiologic Responses to Prolonged Work in Aerobically Trained Men

Effects of potassium-aspartate salt administration on glycogen use in the rat during a swimming stress

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