Effects of the presence or absence of preceding angina pectoris on left ventricular function after acute myocardial infarction

Matsuda, Yasuo; Moritani, Kohshiro; Matsuda, Masako; Naito, Hidetoshi; Matsuzaki, Masunori; Ikee, Y; Kusukawa, Reizo

doi:10.1016/0002-8703(84)90460-5

Cited by 63 publications

(12 citation statements)

References 16 publications

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“…This finding provided experimental support for clinical observations in the mid-1980s, which suggested that post-myocardial infarction patients with a prior history of angina (i.e. myocardial ischaemia) demonstrated a better ejection fraction (Matsuda et al 1984). These data contributed to the concept that exposure to (non-lethal) cardiac ischaemia in the period preceding coronary ischaemia may protect against the impact of reperfusion of the occluded artery on the magnitude of myocardial damage.…”

Section: Application Of Ipc In (Pre)clinical Worksupporting

confidence: 61%

Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms

Thijssen

Maxwell

Green

et al. 2016

Experimental Physiology

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Professor Dick H. J. Thijssen's work is focused on the (primary and secondary) prevention of cardiovascular disease. His work focuses on exploring and understanding the benefits of exercise training and (repeated) ischaemic preconditioning, but also examines the link between the preconditioning effects of exercise and ischaemic preconditioning. The benefits of these interventions are linked to improvement in micro-and macrovessel function and structure, and he explores factors that moderate these effects (e.g. older age, cardiovascular disease). The benefits on the arterial wall, but also activation of the preconditioning pathways, may contribute to the reduction in cardiovascular risk associated with both interventions. His work also aims to understand (haemodynamic) stimuli, such as shear stress and arterial pressure, that mediate improvement in vascular function and structure. Ultimately, this work contributes to identification of (non-)pharmacological strategies in the management of patients with cardiovascular risk and/or disease. New Findings r What is the topic of this review?This review discusses the effects of repeated exposure of tissue to ischaemic preconditioning on cardiovascular function, the attendant adaptations and their potential clinical relevance. r What advances does it highlight?We discuss the effects of episodic exposure to ischaemic preconditioning to prevent and/or attenuate ischaemic injury and summarize evidence pertaining to improvements in cardiovascular function and structure. Discussion is provided regarding the potential mechanisms that contribute to both local and systemic adaptation. Findings suggest that clinical benefits result from both the prevention of ischaemic events and the attenuation of their consequences.Ischaemic preconditioning (IPC) refers to the phenomenon whereby short periods of cyclical tissue ischaemia confer subsequent protection against ischaemia-induced injury. As a consequence, IPC can ameliorate the myocardial damage following infarction and can reduce infarct size. The ability of IPC to confer remote protection makes IPC a potentially feasible cardioprotective strategy. In this review, we discuss the concept that repeated exposure of tissue to IPC may increase the 'dose' of protection and subsequently lead to enhanced protection against ischaemia-induced myocardial injury. This may be relevant for clinical populations, who demonstrate attenuated efficacy of IPC to prevent or attenuate ischaemic injury (and therefore myocardial infarct size).

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Section: Application Of Ipc In (Pre)clinical Worksupporting

confidence: 61%

Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms

Thijssen

Maxwell

Green

et al. 2016

Experimental Physiology

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“…In a study by Matsuda et al 9 , where the ventricular function of 31 patients with total occlusion of the anterior descending coronary artery and stenosis <70% in any other coronary artery was assessed, 16 patients had no history of previous angina. Patients with angina prior to acute myocardial infarction showed better ejection fraction, a lower percentage of abnormalities in contractile segments and in regional motility of the cardiac wall, suggesting that previous angina contributes to preservation of postinfarction ventricular function 7 .…”

Section: Discussionmentioning

confidence: 99%

“…It has not yet been established whether any of the risk factors has an independent participation in the instability of the plaque for triggering myocardial infarction as the first manifestation of ischemic heart disease 7 . Acute myocardial infarction with no previous angina has been suggested to be more prevalent in young males, and to relate to impairment of a single vessel and a better clinical evolution [8][9][10] . Other studies disagree about the importance of these risk factors 10 .…”

mentioning

confidence: 99%

Acute Myocardial Infarction: The First Manifestation of Ischemic Heart Disease and Relation to Risk Factors

Manfroi

Peukert²,

Berti³

et al. 2002

Arq. Bras. Cardiol.

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Objective -To assess the association between cardiovascular risk factors and acute myocardial infarction as the first manifestation of ischemic heart disease, correlating them with coronary angiographic findings. Methods - (RR=0.19; P=0.04) and left ventricular hypertrophy (RR=0.27; 95% CI=0, P=0.03). The remaining risk factors were not statistically significant. Conclusion -Prevalence of acute myocardial infarction as the first manifestation of ischemic

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“…Preconditioning is the paradoxical phenomenon by which brief episodes of ischemia increase the tolerance of the heart to a subsequent major ischemic insult. In animal models, preconditioning by brief ischemia is the most powerful intervention capable of limiting the amount of necrosis due to coronary artery occlusion [34,35]; likewise, in the clinical setting, patients experiencing preinfarction angina score significantly better than those in whom myocardial infarction occurs unheralded [36][37][38][39][40][41][42]. Importantly, small amount of oxidants seem to be involved in mediating preconditioning, and antioxidant treatment indeed abolishes preconditioning in experimental models [43][44][45].…”

Section: Vitamin C and E-that Is "Antioxidant Vitamins"-lessons From mentioning

confidence: 99%

Nutraceuticals in Cardiovascular Prevention: Lessons from Studies on Endothelial Function

Zuchi

Ambrosio

Lüscher

et al. 2010

Cardiovascular Therapeutics

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An “unhealthy” diet is considered as a main cause of increased atherosclerotic cardiovascular disease in the industrialized countries. There is a substantial interest in the potential cardiovascular protective effects of “nutraceuticals,” that is food‐derived substances that exert beneficial health effects. The correct understanding of cardiovascular effects of these compounds will have important implications for cardiovascular prevention strategies. Endothelial dysfunction is thought to play an important role in development and progression of atherosclerosis, and the characterization of the endothelial effects of several nutraceuticals may provide important insights into their potential role in cardiovascular prevention. At the same time, the analysis of the endothelial effects of nutraceuticals may also provide valuable insights into mechanisms of why certain nutraceuticals may not be effective in cardiovascular prevention, and it may aid in the identification of food‐derived substances that may have detrimental cardiovascular effects. These findings further support the notion that nutraceuticals do need support from large clinical outcome trials with respect to their efficacy and safety profile for cardiovascular prevention, before their widespread use can be recommended. In fact, the term nutraceutical was coined to encourage an extensive and profound research activity in this field, and numerous large‐scale clinical outcome trials to examine the effects of nutraceuticals on cardiovascular events have now been performed or are still ongoing. Whereas it is possible that single nutraceuticals may be effective in cardiovascular prevention, this field of research provides also valuable insights into which food components may be particularly important for cardiovascular prevention, to further advice the composition of a particularly healthy diet. The present review summarizes recent studies on the endothelial effects of several nutraceuticals, that have been intensely studied.

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Effects of the presence or absence of preceding angina pectoris on left ventricular function after acute myocardial infarction

Cited by 63 publications

References 16 publications

Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms

Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms

Acute Myocardial Infarction: The First Manifestation of Ischemic Heart Disease and Relation to Risk Factors

Nutraceuticals in Cardiovascular Prevention: Lessons from Studies on Endothelial Function

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