Effects of the SLCO1B1 *1 and SLCO1B1 *5 polymorphisms on IL-6 and IL-10 levels in patients under pravastatin treatment prior to inguinal hernia repair

Cárdenas-Rojas, Martha I.; Delgado‐Enciso, Iván; Baltazar-Rodríguez, Luz M.; Guzmán-Esquivel, José; Ramírez-Flores, Mario

doi:10.1016/j.ijsu.2016.01.036

International Journal of Surgery

2016

DOI: 10.1016/j.ijsu.2016.01.036

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Effects of the SLCO1B1 1 and SLCO1B1 5 polymorphisms on IL-6 and IL-10 levels in patients under pravastatin treatment prior to inguinal hernia repair

Martha I. Cárdenas-Rojas

Iván Delgado‐Enciso

Luz M. Baltazar-Rodríguez

et al.

Abstract: The patients under pravastatin treatment presented with lower postoperative IL-10 levels with respect to the baseline concentration (p = 0.004), regardless of the presence or absence of the two polymorphisms.

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The potential use of transdermal drug delivery for the prophylaxis and management of stroke and coronary artery disease

Ita

2017

Pharmacological Reports

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In 2013, cardiovascular disease was responsible for 30.8% (800,937) of all 2,596,993 deaths, or approximately 1 of every 3 deaths while stroke caused about 1 of every 20 deaths in the United States [1]. To put it in context, about 795,000 people continue to have a new or recurrent stroke (ischemic or hemorrhagic) [1] in the USA. Mechanical vascular recanalization and thrombolysis with tissue plasminogen activator are the only clinically useful approaches available now for the management of ischemic stroke [2]. Antiplatelet therapy with aspirin and/or clopidogrel is also a common practice utilized for the management of stroke, acute myocardial infarction and coronary artery disease [3]. There are two different but closely related approaches to improve therapy- to develop new disease-modifying agents or to find alternative drug administration routes for existing drugs. Transdermal drug delivery leverages the advantages of injections and tablets- painlessness, minimal invasiveness and the avoidance of presystemic metabolism and can potentially be applied to medications used for the prevention and/or management of coronary artery disease and stroke.

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The potential use of transdermal drug delivery for the prophylaxis and management of stroke and coronary artery disease

Ita

2017

Pharmacological Reports

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Effects of the SLCO1B1 1 and SLCO1B1 5 polymorphisms on IL-6 and IL-10 levels in patients under pravastatin treatment prior to inguinal hernia repair

Abstract: The patients under pravastatin treatment presented with lower postoperative IL-10 levels with respect to the baseline concentration (p = 0.004), regardless of the presence or absence of the two polymorphisms.

Cited by 1 publication

References 23 publications

The potential use of transdermal drug delivery for the prophylaxis and management of stroke and coronary artery disease

The potential use of transdermal drug delivery for the prophylaxis and management of stroke and coronary artery disease

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