2017
DOI: 10.1016/j.ygcen.2017.06.008
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Effects of the soya isoflavone genistein in early life stages of the Senegalese sole, Solea senegalensis: Thyroid, estrogenic and metabolic biomarkers

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Cited by 11 publications
(26 citation statements)
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“…vary depending on the species, life stages and developmental patterns, as well as toxicant-type, concentration and routes of exposure, absorption, uptake, metabolism, and detoxification [ 8 , 9 , 18 – 21 ]. Nevertheless, as far as we know, there are very few studies on the effects of flavonoids in the larval fish development and, particularly, focusing on the metamorphosis process of flatfish species, like Senegalese sole [ 22 ]. The majority of phytoestrogens can induce both agonist and antagonist effects at oestrogenic and thyroidal levels, among other hormonal disruptions or endocrine modulations [ 3 , 20 ].…”
Section: Introductionmentioning
confidence: 99%
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“…vary depending on the species, life stages and developmental patterns, as well as toxicant-type, concentration and routes of exposure, absorption, uptake, metabolism, and detoxification [ 8 , 9 , 18 – 21 ]. Nevertheless, as far as we know, there are very few studies on the effects of flavonoids in the larval fish development and, particularly, focusing on the metamorphosis process of flatfish species, like Senegalese sole [ 22 ]. The majority of phytoestrogens can induce both agonist and antagonist effects at oestrogenic and thyroidal levels, among other hormonal disruptions or endocrine modulations [ 3 , 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…Many ontogenetic studies have been performed at physiological, molecular, biochemical, histological and cellular levels in the Senegalese sole development [ 52 54 ]. Nevertheless, in fishes, and particularly in flatfish species that suffer a complex ontogenetic transitional and thyroid-driven metamorphosis [ 22 , 52 55 ], little research has focused on comparative molecular and cellular analysis of cell proliferation and/or apoptosis patterns [ 33 37 ]. However, both cell-life and cell-death pathways are crucial and complementary events necessary for controlling the homeostasis, development, differentiation, growth and survival [ 27 , 28 , 34 , 42 ].…”
Section: Introductionmentioning
confidence: 99%
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