Effects of the sporulation conditions on the lovastatin production by Aspergillus terreus

Porcel, E. Rodríguez; López, J.L. Casas; Ferron, M.; Pérez, J.A. Sánchez; Sánchez, José Francisco Fernandez; Chisti, Yusuf

doi:10.1007/s00449-006-0048-1

Cited by 26 publications

(11 citation statements)

References 14 publications

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“…Lovastatin was the first statin approved by United States Food and Drug Administration as a hypercholesterolemic drug in August 1987 [ 18 , 19 ]. Many fungi such as Monascus (M.) ruber [ 20 ], M. purpureus [ 21 , 22 ], M. pilosus, A. terreus [ 23 , 24 ], A. flavipes [ 25 ], A. fischeri, A. flavus, A. umbrosus, A. parasiticus, Accremonium chrysogenum, P. funiculosum, Trichoderma (T.) viridae and T. longibrachiatum [ 26 ] have been reported to produce lovastatin. Lovastatin is the statin of overwhelming interest because it can be produced naturally and its levels can be scaled up using cheap raw materials, reducing the cost of its production in comparison to chemically synthesized statins.…”

Section: Discovery Of Statinsmentioning

confidence: 99%

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Exploitation of Aspergillus terreus for the Production of Natural Statins

Subhan

Faryal

Macreadie

2016

JoF

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The fungus Aspergillus (A.) terreus has dominated the biological production of the “blockbuster” drugs known as statins. The statins are a class of drugs that inhibit HMG-CoA reductase and lead to lower cholesterol production. The statins were initially discovered in fungi and for many years fungi were the sole source for the statins. At present, novel chemically synthesised statins are produced as inspired by the naturally occurring statin molecules. The isolation of the natural statins, compactin, mevastatin and lovastatin from A. terreus represents one of the great achievements of industrial microbiology. Here we review the discovery of statins, along with strategies that have been applied to scale up their production by A. terreus strains. The strategies encompass many of the techniques available in industrial microbiology and include the optimization of media and fermentation conditions, the improvement of strains through classical mutagenesis, induced genetic manipulation and the use of statistical design.

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Section: Discovery Of Statinsmentioning

confidence: 99%

“…Spore age was determined using modified Box–Behnken design. The final yields of statins increased to 52% [ 23 ]. Goswami et al (2013) used Taguchi design for the optimization of media during production of lovastatin by A. terreus JX081272.…”

Section: Exploitation Of a Terreus For Statin mentioning

confidence: 99%

Exploitation of Aspergillus terreus for the Production of Natural Statins

Subhan

Faryal

Macreadie

2016

JoF

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“…formed a cholesterol-lowering agent, monacolin K, which was proven to possess the identical structure with lovastatin and produced by Monascus pilosus, Aspergillus terreus, Monascus ruber, Monascus purpureus and Penicillium species 2,5,38,40 . Some hyper producing strains of Aspergillus terreus have been reported to produce high amount of lovastatin under submerged fermentation 41 . Angkak fermented by Monascus has been regarded as a functional food having a cholesterol-lowering effect, since monacolin K is identical to lovastatin.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2015

IJPSR

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Angkak rice (red mold rice, red yeast rice, Chinese red rice) which is a product of solid fermentation was prepared from non glutinous rice (Oryza sativa L.). Five different angkak samples containing varied level of lovastatin, pravastatin and citrinin suspension at a dose of 1g/kg were administered to hyperlipidemic rats for 30 days. There was a significant decrease in serum total cholesterol (30.8%), total triglyceride (33.3%), high-density and low-density lipoprotein cholesterol (25.9% and 40.5% respectively) in angkak fed hyperlipidemic rats in comparison to untreated hyperlipidemic rats (p<0.05). No significant difference in serum total cholesterol, total triglyceride, highdensity lipoprotein and low-density lipoprotein cholesterol in serum of hyperlipidemic rats treated with angkak 1 (lovastatin 3.410 mg/g, pravastatin 1.524 mg/g and citrinin 8.345 g/g) and angkak 4 (lovastatin 3.331 mg/g, pravastatin 1.751 mg/g and citrinin 9.874 g/g) in comparison to hyperlipidemic rats treated with standard lovastatin (10 mg/kg) was observed. Animals fed with angkak samples showed no significant difference in their serum creatinine kinase, serum creatinine level and liver enzymes in comparison to normal control rats. INTRODUCTION: Atherosclerosis, a major risk factor for coronary heart disease and myocardial infarction, remains by far the major cause of death. High serum concentration of cholesterol, especially serum low-density lipoprotein cholesterol (LDLc) and lowering of high-density lipoprotein cholesterol (HDLc) are mainly responsible for the development of atherosclerosis 1. Angkak (red mold rice, red yeast rice, Chinese red rice), a traditional Chinese medicine is produced from solid-state fermentation of cooked rice (Orizae sativa L. Gramineae) with Monascus purpureus, M. ruber, M. anka and M. pilosus 2-8 .

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“…The time to sporulation on surface cultures was sensitive to the light exposure history of the fungus and the spore inoculation concentration levels32.…”

Section: Production Of Lovastatinmentioning

confidence: 99%

Microbial production and biomedical applications of lovastatin

Seenivasan¹,

Seraman²,

Aravindan³

et al. 2008

Indian J Pharm Sci

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Lovastatin is a potent hypercholesterolemic drug used for lowering blood cholesterol. Lovastatin acts by competitively inhibiting the enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase involved in the biosynthesis of cholesterol. Commercially lovastatin is produced by a variety of filamentous fungi including Penicillium species, Monascus ruber and Aspergillus terreus as a secondary metabolite. Production of lovastatin by fermentation decreases the production cost compared to costs of chemical synthesis. In recent years, lovastatin has also been reported as a potential therapeutic agent for the treatment of various types of tumors and also play a tremendous role in the regulation of the inflammatory and immune response, coagulation process, bone turnover, neovascularization, vascular tone, and arterial pressure. This review deals with the structure, biosynthesis, various modes of fermentation and applications of lovastatin.

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Effects of the sporulation conditions on the lovastatin production by Aspergillus terreus

Cited by 26 publications

References 14 publications

Exploitation of Aspergillus terreus for the Production of Natural Statins

Exploitation of Aspergillus terreus for the Production of Natural Statins

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Microbial production and biomedical applications of lovastatin

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