Effects of the synthetic enkephalin analogue FK 33-824 in man

Graffenried, B. von; Pozo, E. del; Roubíček, J; Krebs, Eva; Pöldinger, W; Burmeister, P; Kerp, L.

doi:10.1038/272729a0

Cited by 172 publications

(45 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although it has been recently shown that opioid peptides elevate the circulating levels of GH and PRL in man and in experimental animals (46)(47)(48)(49)(50), there is a controversy regarding the mechanism ofaction ofopioid peptides to stimulate hormone release. In rat pituitaries, opioid peptides were found to counteract the inhibitory effect of dopamine on PRL secretion in vitro (51).…”

Section: Methodsmentioning

confidence: 99%

Direct effects of catecholamines, thyrotropin-releasing hormone, and somatostatin on growth hormone and prolactin secretion from adenomatous and nonadenomatous human pituitary cells in culture.

Ishibashi¹,

Yamaji²

1984

J. Clin. Invest.

View full text Add to dashboard Cite

A bstract. To determine the mechanism and the site of action of catecholamines as well as hormones including thyrotropin-releasing hormone (TRH)' and somatostatin on pituitary hormone release in patients with acromegaly and in normal subjects, the effects of these substances on growth hormone (GH) and prolactin (PRL) secretion from adenomatous and nonadenomatous human pituitary cells in culture were examined. When dopamine (0.01-0.1 tM) or bromocriptine (0.01-0.1 tM) was added to the culture media, a significant inhibition of GH

show abstract

Section: Methodsmentioning

confidence: 99%

Direct effects of catecholamines, thyrotropin-releasing hormone, and somatostatin on growth hormone and prolactin secretion from adenomatous and nonadenomatous human pituitary cells in culture.

Ishibashi¹,

Yamaji²

1984

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…Furthermore, the synthetic enkephalin analogue, FK-33-824, causes GH release in man (39). None of the opioids appear to act directly at the pituitary level, and it is likely that they influence the release of GH either by modulating the secretion of releasing-inhibiting factors and/or by affecting neurotransmitters (40,41).…”

Section: Effectsmentioning

confidence: 99%

Regulation of Episodic Growth Hormone Secretion by the Central Epinephrine System

Terry

Crowley

Johnson³

1982

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T Catecholamines are postulated to regulate growth hormone (GH) secretion by their influence on the release of two hypothalamic substances, somatostatin, which inhibits GH release, and GH-releasing factor, as yet unidentified. Extensive pharmacologic studies in man and animals indicate a stimulatory effect of central norepinephrine and dopamine on GH, but the function of epiphephrine (EPI) is uncertain. Furthermore, many of the agents used to study the role of catecholamines in GH regulation are not selective in that they affect adrenergic as well as noradrenergic and/or dopaminergic neurotransmission. In the present investigation, central nervous system (CNS) EPI

show abstract

“…In one of these studies (Von Graffenried et al, 1978), 12 healthy volunteers were injected (i.m.) with 0.1-2 mg of a synthetic analog of ME (FK33 824).…”

Section: Electroencephalogrammentioning

confidence: 99%

Electrophysiological effects of peptides derived from pro-opiomelanocortin

Urban¹

1984

Pharmacology & Therapeutics

View full text Add to dashboard Cite

Effects of the synthetic enkephalin analogue FK 33-824 in man

Cited by 172 publications

References 6 publications

Direct effects of catecholamines, thyrotropin-releasing hormone, and somatostatin on growth hormone and prolactin secretion from adenomatous and nonadenomatous human pituitary cells in culture.

Direct effects of catecholamines, thyrotropin-releasing hormone, and somatostatin on growth hormone and prolactin secretion from adenomatous and nonadenomatous human pituitary cells in culture.

Regulation of Episodic Growth Hormone Secretion by the Central Epinephrine System

Electrophysiological effects of peptides derived from pro-opiomelanocortin

Contact Info

Product

Resources

About