Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review

Goulart, Ricardo de Álvares; Barbalho, Sandra Maria; Lima, Vinícius Marinho; Souza, Gabriela Achete de; Matias, Júlia Novaes; Araújo, Adriano Cressoni; Rubira, Cláudio José; Buchaim, Rogério Leone; Buchaim, Daniela Vieira; Carvalho, Antonely Cassio Alves de; Guiguer, Élen Landgraf

doi:10.1089/jmf.2020.0129

Cited by 46 publications

(38 citation statements)

References 51 publications

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“…Curcumin is able to modulate iron metabolism proteins, reducing the iron stores and restoring its physiological hematic level (81). Despite the description of clinical studies are beyond the scope of the present review, it should be noted that, to date, few clinical studies have been conducted to evaluate the clinical efficacy of curcumin (59,84).…”

Section: Inflammatory Bowel Diseasementioning

confidence: 96%

“…There is some evidence that curcumin-containing supplements may exert anti-inflammatory and analgesic actions in patients with arthritis-related diseases and inflammatory bowel disease (59).…”

Section: O P Y R I G H T E D R a S P Amentioning

confidence: 99%

“…Inflammatory bowel diseases (IBD) represent a set of immune-mediated gastro-intestinal disorders mainly represented by ulcerative colitis (UC) and Chron's disease (CD) (59). The etiology of IBD is still unknown, but it is believed to involve the overstimulation and the excessive response of the intestinal mucosal immune system to resident luminal microorganisms.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

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The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro¹,

Chiavaroli²,

Cicia³

et al. 2021

Pharm Adv

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Curcumin is the major phytoconstituent found in the rhizomes of Curcuma longa L. Preparations derived from the rhizome of the plant, referred as turmeric, have been used for centuries in the traditional Indian system of medicine. The recent literature has shown curcumin as one of the most interesting pleiotropic nutraceuticals capable of interacting with different molecular targets involved in chronic diseases. The present review summarizes and critically discusses the very recent literature published between 2018 and 2021. We focused on the preclinical pharmacological actions of curcumin in relation to its possible clinical application in several pathophysiological states and disturbances including inflammation and pain, as well as metabolic, cardiovascular, dermatological, and central nervous system diseases. The most relevant molecular targets of curcumin, such as transcription factors, pro-inflammatory mediators, enzymes, and protein kinase as well as pharmacokinetics in humans are also reviewed.

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Section: Inflammatory Bowel Diseasementioning

confidence: 96%

Section: O P Y R I G H T E D R a S P Amentioning

confidence: 99%

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

See 1 more Smart Citation

The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro¹,

Chiavaroli²,

Cicia³

et al. 2021

Pharm Adv

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“…Another study on curcumin encapsulated with nanoparticles found it effective against colitis as it modulates GM and regulates T-cells [ 120 ]. The use of curcumin with randomized clinical trials showed therapeutic effects against ulcerative colitis and Crohn’s disease, but meta-analyses showed controversial results about the therapeutic approach [ 121 ]. Tetrahydrocurcumin can decrease the blood glucose level, increase the expression of pancreatic glucagon-like peptide-1, protect islet β cells, and the secretions of insulin in diabetic rats.…”

Section: Curcuminmentioning

confidence: 99%

Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

et al. 2021

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Polyphenols (PPs) are the naturally occurring bioactive components in fruits and vegetables, and they are the most abundant antioxidant in the human diet. Studies are suggesting that ingestion of PPs might be helpful to ameliorate metabolic syndromes that may contribute in the prevention of several chronic disorders like diabetes, obesity, hypertension, and colon cancer. PPs have structural diversity which impacts their bioavailability as they accumulate in the large intestine and are extensively metabolized through gut microbiota (GM). Intestinal microbiota transforms PPs into their metabolites to make them bioactive. Interestingly, not only GM act on PPs to metabolize them but PPs also modulate the composition of GM. Thus, change in GM from pathogenic to beneficial ones may be helpful to ameliorate gut health and associated diseases. However, to overcome the low bioavailability of PPs, various approaches have been developed to improve their solubility and transportation through the gut. In this review, we present evidence supporting the structural changes that occur after metabolic reactions in PPs (curcumin, quercetin, and catechins) and their effect on GM composition that leads to improving overall gut health and helping to ameliorate metabolic disorders.

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“…Interestingly the highest percentage of improvement in the disease activity scores was observed in the curcumin group. Also the RCTs addressing the effect of curcumin on ulcerative colitis and Crohn’s Disease resulted in overall positive outcomes [ 70 ]. In the case of ulcerative colitis it could be shown that the efficacy of adjuvant curcumin therapy may be improved by using enhanced bioavailable formulations and prolonging intervention times [ 71 , 72 ].…”

Section: Curcumin: In Vitro Ic 50 Values Bioavailability and Clinical Efficacymentioning

confidence: 99%

Considerations to Be Taken When Carrying Out Medicinal Plant Research—What We Learn from an Insight into the IC50 Values, Bioavailability and Clinical Efficacy of Exemplary Anti-Inflammatory Herbal Components

Abdel‐Tawab

2021

Pharmaceuticals

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Medicinal plants represent a big reservoir for discovering new drugs against all kinds of diseases including inflammation. In spite the large number of promising anti-inflammatory plant extracts and isolated components, research on medicinal plants proves to be very difficult. Based on that background this review aims to provide a summarized insight into the hitherto known pharmacologically active concentrations, bioavailability, and clinical efficacy of boswellic acids, curcumin, quercetin and resveratrol. These examples have in common that the achieved plasma concentrations were found to be often far below the determined IC50 values in vitro. On the other hand demonstrated therapeutic effects suggest a necessity of rethinking our pharmacokinetic understanding. In this light this review discusses the value of plasma levels as pharmacokinetic surrogates in comparison to the more informative value of tissue concentrations. Furthermore the need for new methodological approaches is addressed like the application of combinatorial approaches for identifying and pharmacokinetic investigations of active multi-components. Also the physiological relevance of exemplary in vitro assays and absorption studies in cell-line based models is discussed. All these topics should be ideally considered to avoid inaccurate predictions for the efficacy of herbal components in vivo and to unlock the “black box” of herbal mixtures.

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Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review

Cited by 46 publications

References 51 publications

The pharmacological basis of the curcumin nutraceutical uses: an update

The pharmacological basis of the curcumin nutraceutical uses: an update

Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota

Considerations to Be Taken When Carrying Out Medicinal Plant Research—What We Learn from an Insight into the IC50 Values, Bioavailability and Clinical Efficacy of Exemplary Anti-Inflammatory Herbal Components

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