Effects of thiacloprid exposure on microbiota–gut–liver axis: Multiomics mechanistic analysis in Japanese quails

Han, Biqi; Li, Jiayi; Li, Siyu; Liu, Yan; Zhang, Zhigang

doi:10.1016/j.jhazmat.2022.130082

Cited by 29 publications

(5 citation statements)

References 56 publications

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“…Damage to the intestinal barrier and alteration in gut microbiota leads to intestinal dysfunction and entry of LPS from Gram-negative bacilli's cell wall, which increases the production of proinflammatory factors and induces visceral hypersensitivity and inflammatory responses. [22] Longterm chronic stress can impair mitochondrial function and activate oxidative stress, inflammatory pathways, or immune responses, ultimately leading to IBS. [4] Among these, oxidative stress has been extensively studied as a possible factor for IBS.…”

Section: Discussionmentioning

confidence: 99%

Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway

Xia,

Tan,

Yuan

et al. 2023

Molecular Nutrition Food Res

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ScopeIrritable bowel syndrome (IBS) is an intestinal disorder, whose symptoms can be alleviated by certain dietary phytochemicals. This study explores the role and potential mechanisms of a natural flavonoid luteolin (LUT) in alleviating the excessive motility of colonic smooth muscles and reducing oxidative stress in IBS with diarrhea (IBS‐D) rats.Methods and resultsLUT reduces excessive intestinal motility and lowers reactive oxygen species (ROS) levels in a water avoidance stress (WAS) rat model. Moreover, LUT increases the protein expression levels of nuclear factor erythroid 2‐related factor 2 (Nrf2) and heme oxygenase‐1 (HO‐1), activates the nuclear translocation of Nrf2, and greatly reduces the hydrogen peroxide (H2O2)‐induced oxidative damage in intestinal epithelial cells.ConclusionsLUT, a phyto‐active component, protects against excessive intestinal motility and diarrhea by regulating the Nrf2 signaling pathway and effectively reduces oxidative stress damage in the colon.

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Section: Discussionmentioning

confidence: 99%

Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway

Xia,

Tan,

Yuan

et al. 2023

Molecular Nutrition Food Res

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“…Second, the species “ Coturnix japonica ” was selected as the organism. Finally, we constructed a network on the basis of target gene from the database 28,40 …”

Section: Methodsmentioning

confidence: 99%

“…Quail (Coturnix coturnix), a representative animal of birds, is typically used to test for toxicity and is the most common test animal used to evaluate the safety of pesticides. 28 Quail is also an excellent food source for human beings because of its high protein, low fat, and low cholesterol characteristics. 29 THI can pose a potential risk to human health by entering and accumulating in the quail.…”

Section: Introductionmentioning

confidence: 99%

Dendrobium officinale polysaccharide alleviates thiacloprid‐induced kidney injury in quails via activating the Nrf2/HO‐1 pathway

Yang,

Guo,

et al. 2024

Environmental Toxicology

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Thiacloprid (THI) is a neonicotinoid insecticide, and its wide‐ranging use has contributed to severe environmental and health problems. Dendrobium officinale polysaccharide (DOP) possesses multiple biological activities such as antioxidant and antiapoptosis effect. Although present research has shown that THI causes kidney injury, the exact molecular mechanism and treatment of THI‐induced kidney injury remain unclear. The study aimed to investigate if DOP could alleviate THI‐induced kidney injury and identify the potential molecular mechanism in quails. In this study, Japanese quails received DOP (200 mg/kg) daily with or without THI (4 mg/kg) exposure for 42 days. Our results showed that DOP improved hematological changes, biochemical indexes, and nephric histopathological changes induced by THI. Meanwhile, THI exposure caused oxidative stress, apoptosis, and autophagy. Furthermore, THI and DOP cotreatment significantly activated the nuclear factor erythroid 2‐related factor 2/heme oxygenase‐1 (Nrf2/HO‐1) pathway, restored antioxidant enzyme activity, and reduced apoptosis and autophagy in quail kidneys. In summary, our study demonstrated that DOP mitigated THI‐mediated kidney injury was associated with oxidative stress, apoptosis, and autophagy via activation of the Nrf2/HO‐1 signaling pathway in quails.

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“…Western blot assay was performed as described previously. 26 Network Pharmacological Analysis. The targets of Res (CAS: 501-36-0) were acquired from the GeneCards database (https:// www.genecards.org/), and 921 results were retrieved.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…The concentrations of protein were detected by the BCA method (Beyotime Biotechnology, Jiangsu, China). Western blot assay was performed as described previously …”

Section: Methodsmentioning

confidence: 99%

Resveratrol Alleviates Liver Fibrosis Induced by Long-Term Inorganic Mercury Exposure through Activating the Sirt1/PGC-1α Signaling Pathway

Li,

Han,

et al. 2024

J. Agric. Food Chem.

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Liver disease has become an important risk factor for global health. Resveratrol (Res) is a natural polyphenol which is widely found in foods and has a variety of biological activities. This study investigated the role of the microbiota-gut-liver axis in the Res relieving the liver fibrosis induced by inorganic mercury exposure. Twenty-eight mice were divided into four groups (n = 7) and treated with mercuric chloride and/or Res for 24 weeks, respectively. The results showed that Res mitigated the ileum injury induced by inorganic mercury and restrained LPS and alcohol entering the body circulation. Network pharmacological and molecular analyses showed that Res alleviated oxidative stress, metabolism disorders, inflammation, and hepatic stellate cell activation in the liver. In conclusion, Res alleviates liver fibrosis induced by inorganic mercury via activating the Sirt1/PGC-1α signaling pathway and regulating the microbial-gut-liver axis, particularly, increasing the relative enrichment of Bif idobacterium in the intestinal tract.

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Effects of thiacloprid exposure on microbiota–gut–liver axis: Multiomics mechanistic analysis in Japanese quails

Cited by 29 publications

References 56 publications

Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway

Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway

Dendrobium officinale polysaccharide alleviates thiacloprid‐induced kidney injury in quails via activating the Nrf2/HO‐1 pathway

Resveratrol Alleviates Liver Fibrosis Induced by Long-Term Inorganic Mercury Exposure through Activating the Sirt1/PGC-1α Signaling Pathway

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