Effects of thiopentone, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs

Smalle, Tesh M.; Hartman, Marthinus Jacobus; Bester, Lynette; Buck, Roxanne K.; Fosgate, Geoffrey T.; Zeiler, Gareth Edward

doi:10.1016/j.vaa.2016.05.013

Cited by 16 publications

(31 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The main finding of this study is that laryngeal function did not differ in dogs anesthetized with propofol or methohexital, prompting us to accept our primary hypothesis. These results are in line with the recent conclusions of Smalle et al, finding propofol superior to thiopentone, also a barbiturate, for evaluation of initial laryngeal function. Our results are also in line with those of Jackson et al, who found thiopental superior for evaluating laryngeal function, but evaluation of initial laryngeal function did not differ between thiopental and propofol.…”

Section: Discussionsupporting

confidence: 92%

“…The addition of ketamine did not palliate the respiratory depression induced by propofol in a study of dogs undergoing evaluation of laryngeal motion . Smalle et al found that lower dosage rates of propofol played an important role in providing a more rapid identification of laryngeal function. Doxapram, a respiratory stimulant, has been found helpful in overcoming the apnea and/or shallow breathing often induced by current anesthetic protocols .…”

Section: Introductionmentioning

confidence: 99%

“…A tentative diagnosis of laryngeal paralysis is based on the dog's history and physical examination findings. The diagnosis is confirmed with direct laryngeal examination, oral laryngoscopy, transnasal laryngoscopy, or echolaryngography . The objective of laryngeal examination is to evaluate arytenoid abduction on inspiration.…”

Section: Introductionmentioning

confidence: 99%

“…Anesthetic protocols that have been evaluated for laryngeal evaluation include propofol, thiopental, ketamine, alfaxalone, and various combinations of these agents . Each of these agents may result in dose‐dependent respiratory depression, affecting the examination.…”

Section: Introductionmentioning

confidence: 99%

“…Jackson et al found that dogs anesthetized with thiopental displayed greater arytenoid motion near recovery than any other protocol used. Smalle et al concluded that propofol was superior because it resulted in shorter examination times without affecting the evaluation of laryngeal function compared with alfaxalone and thiopentone (thiopental). Despite any disparity in preferential induction agents, thiopental is no longer available for clinical use in the United States; propofol is currently the most commonly used anesthetic agent for laryngeal examination.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Comparison of methohexital and propofol as induction agents for evaluation of laryngeal function in healthy dogs

et al. 2018

View full text Add to dashboard Cite

Objective To determine the influence of propofol or methohexital, with and without doxapram, on the examination of laryngeal function in dogs. Study design Experimental study. Animals Forty healthy dogs randomly assigned to 4 groups: propofol with saline (n = 10), propofol with doxapram (n = 10), methohexital with saline (n = 10), or methohexital with doxapram (n = 10). Methods Propofol and methohexital were administered to effect. Investigators examined laryngeal function (initial) simultaneously with video laryngoscopy. Doxapram or saline was administered, and laryngeal function was reevaluated (second). Laryngeal motion, quality of laryngeal exposure, and the degree of swallowing, laryngospasm, and jaw tone were scored at each evaluation. Adverse events were recorded. Initial and second videos were evaluated by a masked observer, and still images obtained from both evaluations were evaluated for change in rima glottidis size by 2 masked observers. Results Administration of doxapram and saline was delayed with propofol (P = .001). Laryngeal function did not differ between dogs receiving propofol or methohexital, irrespective of doxapram administration. Doxapram improved breathing scores in both groups (P < .001). Jaw tone increased with propofol during the second evaluation (P = .049). Swallowing was more prevalent at initial examination (P = .020). Methohexital resulted in an increased heart rate (P < .001) compared with propofol. Twenty‐five percent of dogs receiving methohexital developed seizure‐like activity (n = 5/20). Conclusion Evaluation of laryngeal function did not differ between healthy dogs anesthetized with propofol or methohexital. Methohexital provided shorter examination times with less jaw tone but was associated with adverse events. Clinical significance This study provides evidence to recommend propofol over methohexital as an induction agent for laryngeal function examination.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations