Effects of thoracic and fine PM and their components on heart rate and pulmonary function in COPD patients

Hsu, Sha O-I; Ito, Kazuhiko; Lippmann, Morton

doi:10.1038/jes.2011.7

Cited by 41 publications

(23 citation statements)

References 24 publications

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“…Furthermore, the main living area may represent the location where subjects are awake and active, therefore having higher minute ventilation and increased particle deposition (32), and subsequently increased susceptibility to adverse effects of pollutant exposure. We found no link between pollutant concentrations and changes in lung function, similar to results of previous studies showing no clear association between indoor PM and lung function in few patients with COPD (27,28). NO 2 , a by-product of combustion with indoor sources including gas-burning appliances, may lead to worse respiratory health through airway epithelial damage, or lowering the threshold for viral-induced exacerbations (33,34).…”

Section: Discussionsupporting

confidence: 87%

“…A study including 35 subjects with COPD showed no association between indoor air quality and lung function, with no assessment of other clinical outcomes (27). Another small panel study including 17 subjects with COPD showed no association between PM 2.5 and PM 2.5-10 with lung function over 12 days (28). Our study addresses a significant gap in the evidence by investigating longitudinal health effects of indoor air quality in patients with COPD with repeated comprehensive clinical assessments, including lung function, respiratory symptoms, quality of life, and exacerbations.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, few studies have examined the effect of indoor air quality on COPD morbidity in developed countries, where pollutant burden may be substantially lower; in addition, these studies have focused on quality of life or lung function and are limited by their small sample size or cross-sectional study design, obscuring the effect of indoor air quality on COPD health (22)(23)(24)(25)(26)(27)(28). For example, results from a cross-sectional study by Osman and coworkers (26) suggest that indoor PM 2.5 concentrations are associated with worse quality of life in patients with COPD.…”

Section: Discussionmentioning

confidence: 99%

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In-Home Air Pollution Is Linked to Respiratory Morbidity in Former Smokers with Chronic Obstructive Pulmonary Disease

Hansel¹,

McCormack²,

Belli³

et al. 2013

Am J Respir Crit Care Med

102

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Rationale: The effect of indoor air pollutants on respiratory morbidity among patients with chronic obstructive pulmonary disease (COPD) in developed countries is uncertain. Objectives: The first longitudinal study to investigate the independent effects of indoor particulate matter (PM) and nitrogen dioxide (NO 2 ) concentrations on COPD morbidity in a periurban community. Methods: Former smokers with COPD were recruited and indoor air was monitored over a 1-week period in the participant's bedroom and main living area at baseline, 3 months, and 6 months. At each visit, participants completed spirometry and questionnaires assessing respiratory symptoms. Exacerbations were assessed by questionnaires administered at clinic visits and monthly telephone calls. Measurements and Main Results: Participants (n ¼ 84) had moderate or severe COPD with a mean FEV 1 of 48.6% predicted. The mean (6 SD) indoor PM 2.5 and NO 2 concentrations were 11.4 6 13.3 µg/m 3 and 10.8 6 10.6 ppb in the bedroom, and 12.2 6 12.2 µg/m 3 and 12.2 6 11.8 ppb in the main living area. Increases in PM 2.5 concentrations in the main living area were associated with increases in respiratory symptoms, rescue medication use, and risk of severe COPD exacerbations. Increases in NO 2 concentrations in the main living area were independently associated with worse dyspnea. Increases in bedroom NO 2 concentrations were associated with increases in nocturnal symptoms and risk of severe COPD exacerbations. Conclusions: Indoor pollutant exposure, including PM 2.5 and NO 2 , was associated with increased respiratory symptoms and risk of COPD exacerbation. Future investigations should include intervention studies that optimize indoor air quality as a novel therapeutic approach to improving COPD health outcomes.Keywords: indoor air; chronic obstructive pulmonary disease; particulate matter; nitrogen dioxide; exacerbations Chronic obstructive pulmonary disease (COPD), the third leading cause of death in the United States and the fifth leading cause worldwide, is expected to become increasingly prevalent in upcoming decades (1, 2). Most COPD is caused by environmental exposures; in developed countries, this exposure is primarily cigarette smoke. After COPD begins, evidence indicates that it can be worsened by other environmental exposures. For example, outdoor particulate matter (PM) concentrations have been associated with an increase in COPD hospitalizations and mortality (3, 4). Similarly, outdoor nitrogen dioxide (NO 2 ) exposure has been linked to worse COPD morbidity, including higher rates of exacerbations (4-6).Although substantial evidence shows that outdoor air pollutants impact COPD, there is much less evidence for the impact of indoor air on COPD, especially in developed countries. Although the Global Initiative for Chronic Obstructive Lung Disease guidelines identify indoor air pollution resulting from burning wood and other biomass fuels as a major risk factor for COPD (7), exposures under these conditions are two to three orders of magnitude higher ...

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

In-Home Air Pollution Is Linked to Respiratory Morbidity in Former Smokers with Chronic Obstructive Pulmonary Disease

Hansel¹,

McCormack²,

Belli³

et al. 2013

Am J Respir Crit Care Med

102

View full text Add to dashboard Cite

show abstract

“…However, all subjects lived in the same campus and only temporal variations of PM 2.5 were concerned in this analysis. Further, with almost no indoor sources of PM 2.5 in their living places, fixed-sited measurements may serve as good surrogates of individual exposure to PM 2.5 and its components (Hsu et al, 2011;Janssen et al, 2005). Secondly, the statistical power of this analysis was limited due to the sample size; therefore, a larger study is still needed to confirm our results.…”

Section: Discussionmentioning

confidence: 81%

Association between fine particulate matter chemical constituents and airway inflammation: A panel study among healthy adults in China

Shi

Chen

Yang

et al. 2016

Environmental Research

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“…They also recorded the readouts of the cardiopulmonary function instruments used by the participants, 4 administered a brief questionnaire documenting ventilation status and potential indoor sources within the residences, and reviewed participants’ time-activity diaries from the previous 24 h.…”

Section: Methodsmentioning

confidence: 99%

Factors affecting personal exposure to thoracic and fine particles and their components

Hsu

Ito

Kendall

et al. 2012

J Expo Sci Environ Epidemiol

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Central monitoring site (CMS) concentrations have been used to represent population-based personal exposures to particulate matter (PM) of ambient origin. We investigated the associations of the concentrations of PM2.5 and PM10 and their elemental components for elderly clinic patients with chronic obstructive pulmonary disease in two cities with different PM compositions, that is, New York City (NYC) and Seattle. Daily measurements of CMS, outdoor residential, and indoor PM10 and PM2.5 concentrations, as well as personal PM10, were made concurrently for 12-consecutive winter days at 9 NYC and 15 Seattle residences, as well for 9 NYC residences in summer. Filters were analyzed for elemental components using X-ray fluorescence (XRF), and for black carbon (BC) by light reflectance, and outdoor–indoor–personal relationships of PM components were examined using mixed-effect models. Using sulfur (S) as a tracer of PM of ambient origin, the mean contributions of outdoor PM2.5 was 55.2% of the indoor concentrations in NYC, and 80.0% in Seattle, and outdoor PM2.5 in NYC and Seattle were 19.7 and 18.5% of personal PM2.5 concentration. S was distributed homogeneously in both cities (R2 =0.65), whereas nickel (R2 =0.23) was much more spatially heterogeneous. Thus, CMS measurements can adequately reflect personal exposures for spatially uniform components, such as sulfate, but they are not adequate for components from more local sources.

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Effects of thoracic and fine PM and their components on heart rate and pulmonary function in COPD patients

Cited by 41 publications

References 24 publications

In-Home Air Pollution Is Linked to Respiratory Morbidity in Former Smokers with Chronic Obstructive Pulmonary Disease

In-Home Air Pollution Is Linked to Respiratory Morbidity in Former Smokers with Chronic Obstructive Pulmonary Disease

Association between fine particulate matter chemical constituents and airway inflammation: A panel study among healthy adults in China

Factors affecting personal exposure to thoracic and fine particles and their components

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