Effects of Three Compounds Extracted from<i>Morinda lucida</i>on<i>Plasmodium falciparum</i>

Koumaglo, K.; Gbéassor, Messanvi; Nikabu, O.; Souza, Comlan de; Werner, W.

doi:10.1055/s-2006-961543

Cited by 105 publications

(67 citation statements)

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“…Adanya pemberian tanaman obat tersebut terbukti dapat memperpanjang umur mencit yang terserang malaria dengan mencegah kerusakan pada hati dan limpa. Sudarsono et al, (2002) Koumaglo et al, (1992) dalam Sudarsono et al, (2002) menyatakan bahwa tiga komponen dari ekstrak kulit batang dan kulit akar, yaitu digitolurein, rubiadin-1-metil, dan damnakantal terbukti menghambat pertumbuhan P. falciparum secara in vitro. Selain itu pada P. berghei juga telah dilakukan penelitian, yaitu oleh Obih et al, (1985) menggunakan M. lucida sebagai penghambat pertumbuhan dari P. berghei.…”

Section: Pendahuluanunclassified

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Antimalaria assay of fruit extract of Morinda citrifolia and activity of mice (Mus musculus) macrophage after infecting it with Plasmodium berghei

et al. 2005

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Abstract. Malaria is a world wide disease. Death resulting from the disease was caused by the parasite's resistance to the malaria drugs and the problem of immune system. The aims of the research were to know the effect of M. citrifolia fruit extract to Plasmodium berghei on total red blood cells of mice, and to know the effect of the extract on the number of intraperitoneal macrophage phagocytosing latex after infected by P. berghei. Three doses of fruit extract, 200, 150, 100 mg/kg BB were used in this study. Fansidar was used as positive control, while distilled water was used as negative control. The result of this research indicated that dose of 200 mg/kg BB could reduce number of parasitemia to 3.576%, dose of 150 mg/kg BB to 4.107%, and dose of 100 mg/kg BB to 13.331% on day 5, and could not reduce any number of parasitemia on the next day. Inhibition by Fansidar reached 0.201%, while distilled water did not show any inhibition activity. Different macrophage activity on phagocytosing latex was taken place. The average of macrophage activity on phagocytosing latex at dose of 200 mg/kg BB was 3.8x106 cell, at dose of 150 mg/kg BB was 2.53x106 cell/mL, while at dose 100 mg/kg BB was 1.5x106 cell/mL, and 2.43x106 cell/mL for the control. Based on the results of the study, it can be concluded that the reduction of the number of parasitemia taken place at dose 200 and 150 mg/kg BB, although its activity is much lower than malaria drug of Fansidar. Macrophage activities increased at dose of 200 mg/kg BB.

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Section: Pendahuluanunclassified

“…Bahan aktif yang sering ditemukan pada buah M. citrifolia adalah: L-arginine (Solomon, 1998), xeronine (Wang et al, 2002), senyawa polisakarida (Hirazumi dan Furusawa, 1999), damnakantal (Koumaglo et al 1992) dan antrakuinon. Senyawasenyawa ini antara lain berfungsi sebagai antiviral, sitotoksik, dan antimikrobia (Ali et al, 2000).…”

Section: Pendahuluanunclassified

Antimalaria assay of fruit extract of Morinda citrifolia and activity of mice (Mus musculus) macrophage after infecting it with Plasmodium berghei

et al. 2005

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“…(Rubiacae) is used in herbal decoctions in the treatment of "fevers" Sittie et al (1999), Lemmich et al (1999), malaria Watt (1962); Beyer-Bradwijk (1962) and diabetes Ettarh and Emeka (2004) in Africa. It has been reported that the main compounds that have useful antimalarial activities, which can be extracted from the stem bark and root of M lucida Benth are anthraquinones, digitolutein, rubiadin 1-methyl ether and damnacanthal Sittie et al (1999); Lemmich et al (1999); Koumaglo et al (1992). It has been shown that anthraquinones also have antibacterial properties (Koumaglo et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that the main compounds that have useful antimalarial activities, which can be extracted from the stem bark and root of M lucida Benth are anthraquinones, digitolutein, rubiadin 1-methyl ether and damnacanthal Sittie et al (1999); Lemmich et al (1999); Koumaglo et al (1992). It has been shown that anthraquinones also have antibacterial properties (Koumaglo et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Morinda lucida reduces contractility of isolated uterine smooth muscle of pregnant and non-pregnant mice

Elias

Ladipo²,

Oduwole³

et al. 2010

Nig. J. Phys Sci

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Summary:The present work investigated the effect of Morinda lucida (M. lucida) extract on isolated uterine smooth muscle of pregnant and non-pregnant mice. Pregnant and non-pregnant mice were pretreated with oral stilboesterol (0.1mg/kg body weight) and killed by cervical dislocation. Thin strips of the uterus were cut and mounted in a 20-ml organ bath containing De Jalon solution bubbled with 95%O 2 -5% CO 2 gas mixture. The strips were connected to a force transducer coupled to a Grass 7D Polygraph for the recording of isometric tension. Effects of graded concentrations of oxytocin (OXY; 10 -5 -10 -2 mol/L), acetylcholine (ACh; 10 -9 -10 -5 mol/L) and M. lucida extract (0.015-1.5mg/ml) were recorded. Fresh uterine strips were then incubated with M. lucida extract for 5mins and cumulative response to OXY was repeated. Another set of fresh strips was incubated in L-NAME for 15mins and the cumulative responses to M.lucida extract were repeated. OXY resulted in increased contractile responses in both pregnant and non-pregnant uterine muscles. M. lucida resulted in relaxation of the uterine smooth muscle in both pregnant and non-pregnant mice at all doses. However, at 1.500mg/ml, M. lucida completely blocked spontaneous uterine contractions. Following incubation with L-NAME, M. lucida extract led to a slightly greater relaxation of the uterine strips. In conclusion, M. lucida reduced contractility of uterine smooth muscle in both pregnant and non-pregnant mice as well as blocking contractile responses to OXY and Ach in uterine smooth muscle of pregnant and nonpregnant mice. There was no significant alteration of M. lucida activity by L-NAME suggesting that the action of the compound on uterine muscle is not associated with impaired nitric oxide synthase.

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“…A decoction of leaves and stems is used as a vermifuge (Williams, 2002). Scientific studies show that the anthraquinones of the Rubiaceae family exhibit some interesting in vivo biological activities, such as antimicrobial (Sittie et al, 1999), antifungal (Rath et al, 1995), hypotensive, analgesic (Younos et al, 1990), antimalarial (Adwankar and Chitnis, 1982;Koumaglo et al, 1992), antioxidant (Tripathi et al, 1997), antileukemic and mutagenic functions (Chang et al, 1995;Ismail et al, 1997). Apart from its medicinal value, this plant has also been used as natural food colorants and as natural hair dye (Samatha et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Rubia cordifolia: a review

Patil¹,

Mohan²,

Kasture³

et al. 2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYMedicinal herbs are significant source of synthetic and herbal drugs. In the commercial market, medicinal herbs are used as raw drugs, extracts or tinctures. Isolated active constituents are used for applied research. For the last few decades, phytochemistry (study of plants) has been making rapid progress and herbal products are becoming popular. According to Ayurveda, the ancient healing system of India, the classical texts of Ayurveda, Charaka Samhita and Sushruta Samhita were written around 1000 B.C. The Ayurvedic Materia Medica includes 600 medicinal plants along with therapeutics. Herbs like turmeric, fenugreek, ginger, garlic and holy basil are integral part of Ayurvedic formulations. The formulations incorporate single herb or more than two herbs (poly-herbal formulations). Medicinal herb contains multitude of chemical compounds like alkaloids, glycosides, saponins, resins, oleoresins, sesquiterpene, lactones and oils (essential and fixed). Today there is growing interest in chemical composition of plant based medicines. Several bioactive constituents have been isolated and studied for pharmacological activity. R. cordifolia is an important medicinal plant commonly used in the traditional and Ayurvedic system of medicine for treatment of different ailments. This review illustrates its major constituents, pharmacological actions substantiating the claims made about this plant in the traditional system of medicine and its clinical applications.

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Effects of Three Compounds Extracted fromMorinda lucidaonPlasmodium falciparum

Cited by 105 publications

References 1 publication

Antimalaria assay of fruit extract of Morinda citrifolia and activity of mice (Mus musculus) macrophage after infecting it with Plasmodium berghei

Antimalaria assay of fruit extract of Morinda citrifolia and activity of mice (Mus musculus) macrophage after infecting it with Plasmodium berghei

Morinda lucida reduces contractility of isolated uterine smooth muscle of pregnant and non-pregnant mice

Rubia cordifolia: a review

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