Effects of Three Types of Japanese Honey on Full-Thickness Wound in Mice

Nakajima, Yukari; Nakano, Yoshiaki; Fuwano, Sono; Hayashi, Natsumi; Hiratoko, Yukiho; Kinoshita, Akio; Miyahara, Megumi; Mochizuki, Tsuyoshi; Nishino, Kasumi; Tsuruhara, Yusuke; Yokokawa, Yoshika; Iuchi, Terumi; Kon, Yuka; Mukai, Kanae; Kitayama, Yukie; Murakado, Naoko; Okuwa, Mayumi; Nakatani, Toshio

doi:10.1155/2013/504537

Cited by 27 publications

(29 citation statements)

References 22 publications

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“…However, wound areas Indonesian and Japanese honey did not increase during this phase, but rapidly decreased until the wounds healed by day 14. This result is similar in our previous study (Nakajima, Y., Nakano, Y., Fuwono, 2013). The effect of honey on decreasing wound area because of anti-inflammatory action (Ghaderi, R & Afshar, 2004).…”

Section: Discussionsupporting

confidence: 92%

“…Japanese already has known honey including Acacia, and Buckwheat honey. Yamada Bee Farm, Okayama, Japan reported Acacia honey is composed of 70.8% glucose and fructose and 18.6% water, and Buckwheat flour honey is composed of 71.2% glucose and fructose and 17.2% water (Nakajima, Y., Nakano, Y., Fuwono, 2013). On the other hand, Indonesia has many of kinds of honey.…”

Section: A R T I C L E I N F O Abstractmentioning

confidence: 99%

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Evaluation of Indonesian and two types of Japanese honey on the acceleration of cutaneous wound healing: an experimental study in mice

Haryanto

Mukai

Nakajima

et al. 2019

J. Heal. Technol. Assess. Midwifery

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The purpose of this study is to evaluate and clarify the effect of Indonesian honey, two types of Japanese honey and hydrocolloid dressing on wound healing process. Four groups of male mice were treated to produce two circular full-thickness skin wounds on the dorsum. They were then randomly allocated to receive daily Indonesian honey, Japanese honey (Buckwheat and Acacia honey) or hydrocolloid dressing as a control for treatment application. Macroscopic findings were observed from day 0 to 14 after wounding. Microscopic evaluation was assessed using qualitative analysis. The ratios of wound areas for honey groups on day 3 and 7 were smaller than those of the control group. Wound areas of honey groups gradually decreased to almost the same wound area as the control group on day 14, while the wound area of the control group peaked on day 5 and rapidly decreased until day 14. Microscopic finding that Indonesian honey was different with Japanese honey especially Buckwheat honey.

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Section: Discussionsupporting

confidence: 92%

Section: A R T I C L E I N F O Abstractmentioning

confidence: 99%

Evaluation of Indonesian and two types of Japanese honey on the acceleration of cutaneous wound healing: an experimental study in mice

Haryanto

Mukai

Nakajima

et al. 2019

J. Heal. Technol. Assess. Midwifery

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“…Recently, the potent activity of honey against antibiotic-resistant bacteria has further increased the interest for application of honey. Several honeys have been approved for clinical application [4][5][6]. A review of different antibacterial studies showed that the antibacterial properties of honey depend on the geographical origin of the honey [7] Honey bees has been traditionally recognized as valuable source of energy which contains antibacterial and antifungal proprieties [8].…”

Section: Introductionmentioning

confidence: 99%

Colour Intensity, Polyphenol Content and Antibacterial Capacity of Unheated and Heat-Treated Sahara Honey

Ahmed¹,

Khiati²,

Saad³

et al. 2016

J Food Process Technol

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The objective of this research work was to evaluate the effect of heat processing on antibacterial capacity of Sahara honey (SH). Various thermal treatments were carried out at 25°C, 50°C, 75°C and 100°C for 15 min, 30 min, and 60 min, and the parameters were determined: colour intensity, phenolic contents and antibacterial activity of two species of bacteria (Staphylococcus aureus and Pseudomonas aeruginosa). The total phenolic contents in honey samples varied from 0.55 and 1.54 mg of gallic acid equivalent (GAE) in gram of honey. MIC values respectively 3.12 to 12.5 mg/ml and zone of growth inhibition respectively 2.65 mm to 19 mm. Exposures of SH at 75°C and 100°C, no inhibition of Staphylococcus aureus and Pseudomonas aeruginosa growth was detected. Statistical analysis demonstrated positive correlations between color intensity and polyphenol contents and negative correlations with antibacterial capacity. Data from present results revealed that unheated and heat-treated Sahara honey showed growth inhibitory effect against Staphylococcus aureus and Pseudomonas aeruginosa with variable degrees.

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“…When used properly, the use of honey is safe and does not involve complications. Japanese honey alone has limited benefit, although it reduces wound size in the inflammatory phase (28) …”

Section: Discussionmentioning

confidence: 99%

Review of animal models used to study effects of bee products on wound healing: findings and applications

Hananeh

Ismail

Alshehabat

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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Non-healing wounds are associated with high morbidity and might greatly impact a patient's well-being and economic status. For many years, scientific research has focused on developing and testing several natural and synthetic materials that enhance the rate of wound healing or eliminate healing complications. Honey has been used for thousands of years as a traditional remedy for many ailments. Recently, honey has reemerged as a promising wound care product especially for infected wounds and for wounds in diabetic patients. In addition to its proposed potent broad-spectrum antibacterial properties, honey has been claimed to promote wound healing by reducing wound hyperaemia, oedema, and exudate, and by stimulating angiogenesis, granulation tissue formation and epithelialisation. Several animal models, including large animals, dogs and cats, and different species of laboratory animals have been used to investigate the efficacy and safety of various natural and synthetic agents for wound healing enhancement. Interpreting the results obtained by these studies is, however, rather difficult and usually hampered by many limiting factors including great variation in types and origins of honey, the type of animal species used as models, the type of wounds, the number of animals, the number and type of controls, and variation in treatment protocols. In this article, we provide a comprehensive review of the most recent findings and applications of published experimental and clinical trials using honey as an agent for wound healing enhancement in different animal models.

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Effects of Three Types of Japanese Honey on Full-Thickness Wound in Mice

Cited by 27 publications

References 22 publications

Evaluation of Indonesian and two types of Japanese honey on the acceleration of cutaneous wound healing: an experimental study in mice

Evaluation of Indonesian and two types of Japanese honey on the acceleration of cutaneous wound healing: an experimental study in mice

Colour Intensity, Polyphenol Content and Antibacterial Capacity of Unheated and Heat-Treated Sahara Honey

Review of animal models used to study effects of bee products on wound healing: findings and applications

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