Effects of thyroid dysfunction on serum calcium in the rat

Gammage, Michael D.; Logan, S.D.

doi:10.1042/cs0710271

Cited by 13 publications

(11 citation statements)

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“…Gammage reported negative correlation of serum phosphorous with TSH. The study of Kavitha et al showed significant positive correlation (p< 0.003) with TSH in overt hypothyroidism [22].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Minerals and Electrolytes In Thyroid Patients

Shrestha¹,

Bharti²,

Rai³

et al. 2015

Int J of Adv in Sci Res

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Introduction: The effect on thyroid hormones on electrolytes and minerals has not been well established and the underlying mechanisms are not well understood. Only few data on the association between thyroid function and electrolyte disorders exists. Thus our aim was to assess the levels of serum electrolytes and minerals in the patients with thyroid disorders. Materials and methods: 75 patients and 30 controls were included. Thyroid hormones (T3, T4, TSH) were measured by vidas autoanalyser. Serum calcium, phosphorous and magnesium were estimated by kit based method using semiautoanalyser. Serum sodium, potassium and chlorides were estimated using ion selective electrodes. Statistical analysis was done using SPSS 16. Results: Patients with subclinical hypothyroidism and overt hypothyroidism showed significant decrease in serum calcium and sodium levels and significant increase in serum phosphorous, magnesium, potassium and chloride levels (p<0.05). In case of subclinical hyperthyroidism significant difference could not be obtained among controls and patients (p>0.05). However for overt hyperthyroid patients, serum phosphorous was significantly decreased and serum sodium was increased significantly (p<0.05). Rest of the results were non significant. When correlated with TSH, serum calcium and sodium showed negative correlation whereas it was positive for serum phosphorous, magnesium, potassium and chloride in case of hypothyroidism. For hyperthyroid patients, correlation was negative for magnesium and chloride whereas positive for the rest parameters. But none of correlations were statistically significant (p>0.05). Conclusion: Thyroid patients should be regularly checked for serum electrolytes. Early detection and treatment can prevent the further complications and will be helpful during the management of thyroid patients.

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“…Gammage reported negative correlation of serum phosphorous with TSH. The study of Kavitha et al showed significant positive correlation (p< 0.003) with TSH in overt hypothyroidism [22].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Minerals and Electrolytes In Thyroid Patients

Shrestha¹,

Bharti²,

Rai³

et al. 2015

Int J of Adv in Sci Res

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“…Previous studies carried out on serum calcium and phosphorus levels in thyroid disorders had conflicting results. Some studies reported normal levels [19,20], while others reported decreased serum calcium and phosphorus levels in hypothyroidism [21]. Vitamin D has been reported to be deficient in the hypothyroid patients [32].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies carried out on serum calcium and phosphorus levels in thyroid disorders have had conflicting results. Some studies have reported normal levels [19,20], while others have reported decreased serum calcium and phosphorus levels in hypothyroidism [21]. Hyperthyroidism causes excessive excretion of calcium and phosphorus in urine because the high serum calcium levels in hyperthyroidism have a negative feedback on the secretion of parathyroid hormone which has a role in calcium and phosphorus absorption [22].…”

Section: Introductionmentioning

confidence: 99%

Incidence of Thyroid Diseases in Female Saudi Adults Visiting a Tertiary Care Hospital in Riyadh

Hasanato¹,

Mirah²,

Al-Shahrani³

et al. 2017

Epidemiology (Sunnyvale)

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Introduction: Diseases of the thyroid gland are common in adults and the prevalence is increasing in all parts of the world. Ethnicity and geographical locations also affect the prevalence of thyroid disorders along with the age, sex and iodine-intake by the different populations. The objective of our study is to examine the prevalence of thyroid dysfunction in female Saudi adults. It is a quantitative, observational, cross-sectional study involving 199 female Saudi adults visiting the King Khalid University Hospitals, Riyadh. Recruitment of subjects was done by random sampling.

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“…At the same time, in the blood serum of thyrotoxicosis patients who have undergone 131 I treatment the reduction in the thyroxin level was accompanied also by a reduction in the calcitonin level (Bayaraktar, 1990). In such patients there was a reduction in the stability of reaction to the induction of high doses of calcium, thus giving evidence of a breakdown in calcium homeostasis (Gammage, 1986). It is obvious that this is a direct consequence of radiation damage and the breakdown in the production of calcitonin by the C-cells which have direct contact with the thyrocytes (Bayraktar, 1990;Tzanela et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

The influence of maternal hypothyroidism and radioactive iodine on rat embryonal development: Thyroid C‐cells

Usenko

Lepekhin

Lyzogubov³

et al. 1999

Anat. Rec.

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There have been no works devoted to the study of the influence of 131 I and maternal 131 I-induced hypothyroidism on the state of the C-cells in the thyroid gland of the developing embryos. A study was made on the effect of a dose of 150 µCi 131 I (0.5 Gy) leading to hypothyroidism in rats, on 35 mother rats and 168 newborn pups. The mother rats were divided into control and four treated groups which were injected with 131 I before pregnancy, on gestation days 5, 10, and 16, respectively. Immunohistochemically, the thyroid gland was examined for calcitonin-positive cells. Maternal hypothy-roidism induced by 131 I leads to the development of hyperplasia and hyperthrophy of calcitonin-positive cells in the pups at the time of birth. The discovery of separate C-cells in the peripheral zone of the thyroid lobe may be evidence of an unbalance in the development of the medial and lateral source of the thyroid. There is a verifiable increase in the quantity of C-cells per 1 mm 2 field of the localization in the central zone of the gestation days 10 and 16 groups. This might be a compensatory mechanism for regulating the activity of the thyroid gland under induced hypothyroidism. Thus, in cases when there is a breakdown in the normal external regulation of the embryonic morphogenesis, a reduction in the level of maternal thyroid hormones and also direct exposure to 131 I, there is also a change in the foetus' internal regulatory systems. A change in C-cell system could lead to the appearance of endocrinological disorders later in life. Anat Rec 256:7-13, 1999.

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Effects of thyroid dysfunction on serum calcium in the rat

Cited by 13 publications

References 0 publications

Assessment of Serum Minerals and Electrolytes In Thyroid Patients

Assessment of Serum Minerals and Electrolytes In Thyroid Patients

Incidence of Thyroid Diseases in Female Saudi Adults Visiting a Tertiary Care Hospital in Riyadh

The influence of maternal hypothyroidism and radioactive iodine on rat embryonal development: Thyroid C‐cells

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