Effects of thyroid hormone imbalance on colorectal cancer carcinogenesis and risk — a systematic review

Rostkowska, Olga; Spychalski, Piotr; Dobrzycka, Małgorzata; Wilczyński, Maciej; Łachiński, Andrzej J.; Obołończyk, Łukasz; Sworczak, Krzysztof; Kobiela, Jarek

doi:10.5603/ep.a2019.0007

Cited by 11 publications

(5 citation statements)

References 30 publications

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“…At the same time increased TSH level is associated with poor prognosis for endometrial carcinoma patients [ 117 ]. A meta-analysis study reported an elevated risk of colorectal cancer in patients with hypothyroidism and thyroid replacement therapy has a protective role [ 118 ].…”

Section: Disorders and Diseases Associated With Thyroid Dysfunctionmentioning

confidence: 99%

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Kumari

Chainy

Subudhi

2020

Heliyon

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Section: Disorders and Diseases Associated With Thyroid Dysfunctionmentioning

confidence: 99%

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Kumari

Chainy

Subudhi

2020

Heliyon

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“…Truncated TRΔβ3 lacks the DNA binding domain but retains T 3 binding activity and acts as a dominant-negative antagonist, similar to TRΔα1 and TRΔα2 (6)(7)(8)(9). Several studies to date have reported aberrant expression and/or somatic mutations of TR in human cancers (3,(10)(11)(12)(13)(14)(15)(16)(17)(18), including hepatocellular carcinoma (HCC) (19)(20)(21)(22)(23)(24)(25)(26)(27)(28).…”

Section: Introductionmentioning

confidence: 99%

Thyroid hormones suppress FOXM1 expression to reduce liver cancer progression

Yeh

Lin

2020

Oncol Rep

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Thyroid hormones (TH) are multifunctional mediators that fine-tune several physiological processes, including metabolic rate, digestive function and tissue development via interactions with type II nuclear thyroid hormone receptors (TR). Upon binding of TH, TRs interact specifically with thyroid hormone response elements of target gene promoter regions to regulate their transcription. Earlier studies suggested a correlation between aberrant TR regulation and hepatocellular carcinoma (HCC). THs are involved in a crosstalk between hepatoma and stromal cells, and disruption of TH signaling is associated with tumorigenesis. Previous cDNA microarray analysis of target gene expression following T 3 treatment of wild-type TR-expressing hepatoma cells led to the identification of forkhead box M1 (FOXM1) as a factor negatively regulated by T 3 and associated with poor prognosis in several cancer types. Increased FOXM1 expression during late stages of HCC was associated with poorer overall and recurrence-free survival in patients with HCC. However, the specific mechanisms underlying FOXM1 activity in liver cancer progression remain to be elucidated. Experiments from the present study showed that TH/TR signaling suppresses FOXM1 mRNA and protein expression. Depletion of FOXM1 induced inhibition of the cell growth rate and a decline in oncogenic cyclin D1, cyclin E and CDK2 expression. Conversely, overexpression of FOXM1 enhanced cell proliferation and expression of oncogenic factors, which was decreased upon FOXM1 depletion. Re-expression of FOXM1 partially rescued suppression of cell proliferation induced by T 3 . Collectively, the present findings suggest that TH/TR participates in HCC progression via modulation of FOXM1 expression.

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“…In clinical studies, hyperthyroidism is correlated with cancer prevalence in various cancer types, including liver, thyroid, brain, breast, lung, and colorectal cancer [ 44 , 45 ]. However, no such relationship between autoimmune hyperthyroidism and lung cancer was found in our Mendelian study.…”

Section: Discussionmentioning

confidence: 99%

The causal relationship between thyroid function, autoimune thyroid dysfunction and lung cancer: a mendelian randomization study

Wang,

Liu,

et al. 2023

BMC Pulm Med

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Background The role of thyroid hormones in cancers has been discussed in observational studies; however, the causal relationship between them remains controversial. Methods The SNPs associated with hypothyroidism and hyperthyroidism were selected from a FinnGen biobank of 342,499 (190,879 females and 151,620 males) Finnish adult subjects. Data from the Thyroidomics Consortium on 72,167 individuals were used to assess genetically determined thyroid-stimulating hormone (TSH) and free thyroxine (FT4). Lung cancer, lung adenocarcinoma and squamous cell lung cancer GWAS data from the International Lung Cancer Consortium(ILCCO). Six different Mendelian randomization (MR) Methods, including Inverse variance weighted (IVW), MR-Egger, Simple mode, MR-Pleiotropy Residual Sum and Outlier methods (MR-PRESSO), Weighted mode and Weighted median were used to Two-Sample MR analysis. IVW was used as the primary estimate. Sensitivity analyses were examined via four aspects (Cochran’s Q-test, MR Egger intercept analysis, Funnel plot and Leave-one-out sensitivity test). Results The OR of hypothyroidism on lung cancer was 0.918 (95% CI, 0.859–0.982; p = 0.013) in MR analysis with IVW method. No evidence for effects of hyperthyroidism, TSH and FT4 on lung cancer risk was found via six MR methods. Meanwhile, there was no evidence for effects of lung cancer on hypothyroidism through six MR methods. Lung adenocarcinoma and squamous cell lung carcinoma were further analyzed on the basis of lung cancer. The OR of hypothyroidism on lung adenocarcinoma was 0.893(95% CI, 0.813–0.981; p = 0.019), the OR of hypothyroidism on squamous cell lung cancer was 0.888(95%CI,0.797–0.990, p = 0.032) in MR analysis with IVW method. Conclusion In summary, hypothyroidism genetically had a protective causal association with lung cancer. Furthermore, hypothyroidism had protective effects both on lung adenocarcinoma and squamous cell lung cancer. Further work is needed to elucidate the potential mechanisms.

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Effects of thyroid hormone imbalance on colorectal cancer carcinogenesis and risk — a systematic review

Cited by 11 publications

References 30 publications

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Thyroid hormones suppress FOXM1 expression to reduce liver cancer progression

The causal relationship between thyroid function, autoimune thyroid dysfunction and lung cancer: a mendelian randomization study

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