Effects of thyroid hormone on angiotensinogen and renin messenger RNA levels in rats.

Abstract

Abstract-We studied the expression of angiotensinogen and renin genes in rats treated with 3,3',5-triiodo-L-thyronine (T3) at doses of 0.1 and 1 mg/kg of body weight. Liver angiotensinogen mRNA increased by 2 to 3 times 8 to 12 hours after T3-treatment. This increase was dose-related. Plasma angiotensinogen concen tration (PAC) increased 12 hours after T3-treatment. Brain and renal angiotensi nogen mRNA levels and the renal renin mRNA level remained the same throughout the experimental periods. These results suggest that the thyroid hormone initially increases angiotensinogen mRNA and leads to an increase in the production of angiotensinogen in the liver followed by an elevation of PAC.

Hipotireoidismo congênito: rastreamento e identificação de mutações no gene TPO em pacientes com defeito parcial ou total de incorporação de iodeto

“…Posteriormente foram descritas as sequências de aminoácidos de outras peroxidases de mamíferos tais como a mieloperoxidase (MPO) (Johnson, et al, 1987), lactoperoxidase (LPO) (Dull et al, 1990), peroxidase salivar (SPO) (Kiser et al, 1990) e a peroxidase eosinófila (EPO) (Sakamaki et al, 1989). Sugere-se uma origem ancestral comum da TPO e da mieloperoxidase dos granulócitos, pelo fato de haver homologia de 42% entre os dois genes (Libert et al, 1987;, Kimura, 1990.…”