Effects of Thyroid Hormones on Heart and Kidney Functions

Capasso, Giovambattista; Tommaso, G. De; Pica, Angelo; Anastasio, P; Capasso, J. M.; Kinne, R; Santo, Natale G. De

doi:10.1159/000057421

Cited by 60 publications

(39 citation statements)

References 30 publications

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“…The apparent close relation between the plasma homocysteine and thyroid hormone levels indicates a hormone effect on homocysteine metabolism, distribution, or clearence. A similar argument can be made for the creatinine and cholesterol responses [8][9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 67%

Plasma Homocysteine Levels in Hyperthyroid Patients

et al. 2004

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Abstract. Hyperhomocysteinemia is a risk factor for premature atherosclerotic vascular diseases. It is known that plasma homocysteine levels are higher in hypothyroid patients compared to healthy subjects. The aim of our study was to assess plasma total homocysteine concentrations in hyperthyroid patients before and after treatment when euthyroid status was reached and compare them with control group. Thirteen hyperthyroid patients (age, 42.9 ± 15.6 year) and eleven healthy subjects (age, 39.9 ± 12.5 year) were involved in the study. Plasma levels of homocysteine and serum cholesterol, triglyceride, HDL cholesterol, urea, creatinine, vitamin B12, folate were measured before and after treatment. LDL cholesterol and creatinine clearences were calculated. Pretreatment homocycteine levels of the hyperthyroid patients were significantly lower than healthy controls (11.5 ± 3.6 mmol/L vs. 15.1 ± 4.5 mmol/L, respectively, p<0.05). Posttreatment homocysteine levels were significantly higher than pretreatment levels (13.9 ± 6.3 mmol/L vs. 11.5 ± 3.6 mmol/L, respectively, p<0.05) and posttreatment creatinine clearance were lower than pretreatment level (103.5 ± 12.7 ml/min vs. 114.2 ± 9.3 ml/min, respectively, p<0.01). Lower homocysteine levels in hyperthyroidism can be partially explained with the changes in creatinine clearance.

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Section: Discussionmentioning

confidence: 67%

Plasma Homocysteine Levels in Hyperthyroid Patients

et al. 2004

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“…Although intracellular pH has been linked to diverse cellular functions in various tissues, including cell proliferation, trans- formation, and differentiation (1,33,34), extracellular acidification also occurs in a regulated manner. The NHE family of Na ϩ /H ϩ exchangers is ubiquitous, and their role in acid-base balance is best understood in kidney (33), where concentrationdriven influx of Na ϩ provides the driving force for the NHEmediated extrusion of H ϩ into the extracellular domain.…”

Section: Nhe1 Regulates Epidermal Ph and Barrier Functionmentioning

confidence: 99%

“…The NHE family of Na ϩ /H ϩ exchangers is ubiquitous, and their role in acid-base balance is best understood in kidney (33), where concentrationdriven influx of Na ϩ provides the driving force for the NHEmediated extrusion of H ϩ into the extracellular domain. NHE1 and NHE3 are responsible for intracellular pH regulation, but also H ϩ secretion/HCO 3 Ϫ reabsorption along the proximal nephron (33,35). In osteoclasts, as in SC, NHE1 is responsible for H ϩ secretion, which, similar to SC, occurs in localized microdomains (reviewed in Ref.…”

Section: Nhe1 Regulates Epidermal Ph and Barrier Functionmentioning

confidence: 99%

NHE1 Regulates the Stratum Corneum Permeability Barrier Homeostasis

Behne

Meyer

Hanson

et al. 2002

Journal of Biological Chemistry

190

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The outermost epidermal layer, the stratum corneum (SC), exhibits an acidic surface pH, whereas the pH at its base approaches neutrality. NHE1 is the only Na ؉ /H ؉ antiporter isoform in keratinocytes and epidermis, and has been shown to regulate intracellular pH. We now demonstrate a novel function for NHE1, as we find that it also controls acidification of extracellular "microdomains" in the SC that are essential for activation of pH-sensitive enzymes and the formation of the epidermal permeability barrier. NHE1 expression in epidermis is most pronounced in granular cell layers, and although the surface pH of NHE1 knockout mice is only slightly more alkaline than normal using conventional pH measurements, a more sensitive method, fluorescence lifetime imaging, demonstrates that the acidic intercellular domains at the surface and of the lower SC disappear in NHE1 ؊/؊ animals. Fluorescence lifetime imaging studies also reveal that SC acidification does not occur through a uniform gradient, but through the progressive accumulation of acidic microdomains. These findings not only visualize the spatial distribution of the SC pH gradient, but also demonstrate a role for NHE1 in the generation of acidic extracellular domains of the lower SC, thus providing the acidification of deep SC interstices necessary for lipid processing and barrier homeostasis.

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“…Реализация указанных механизмов мо-жет быть связана с неспецифическим действи-ем ЙТГ на проницаемость клеточных мембран [30] и активность энергетических процессов в митохондриях [31], от которых также зависят уровень и активность протеолитических фер-ментов [32], и фундаментальным действием ЙТГ на геном, доказанным, в том числе, и в наших опытах по изучению экспрессии генов раннего ответа в миокарде. Оно может реа-лизоваться, во-первых, классическим путем -в результате связывания Т 3 с рецепторами тиреоидных гормонов (TRα1 и TRβ1) в спец-ифических элементах ответа (Тhyroid hormone Response Elements (TREs)), расположенных в промоторных областях генов-мишеней; во-вторых, недавно открытым неклассическим [33] за счет:…”

Section: Discussionunclassified