Effects of tibolone on osteoarthritis in ovariectomized rats: Association with nociceptive pain behaviour

Yang, Pei-Yin; Cc, Tang; Yc, Chang; Huang, Sheng-Lung; Sp, Hsieh; Ss, Fan; Hp, Lee; Sc, Lin; Wf, Chen; Zh, Wen; Yh, Jean

doi:10.1002/j.1532-2149.2013.00406.x

Cited by 19 publications

(18 citation statements)

References 52 publications

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“…The results of OA score and the histopathological and immunohistochemical data of TGF-β were only compared amongst groups for the right (injury) legs. In our previous study 42 , the OA scores and histopathological findings of the contralateral non-injury legs showed normal findings.…”

Section: Discussionmentioning

confidence: 71%

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Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes

Wen

Tang

Chang

et al. 2016

Sci Rep

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We investigated the role of the calcitonin (Miacalcin) in the progression of osteoarthritis (OA) and in nociceptive behavior in an experimental rat model of OA and osteoporosis. OA was induced by anterior cruciate ligament transection (ACLT) of the right knee and by bilateral ovariectomy (OVX) in Wistar rats. Nociceptive behaviors (secondary mechanical allodynia and weight-bearing distribution of the hind paws) were analyzed prior to surgery and every week, beginning at 12 weeks after surgery, up to 20 weeks. At 20 weeks, histopathological studies were performed on the cartilage of the knee joints. Immunohistochemical analysis was performed to examine the effect of calcitonin on transforming growth factor (TGF)-β1 expression in articular cartilage chondrocytes. Rats subjected to ACLT + OVX surgery showed obvious OA changes in the joints. Animals subjected to ACLT + OVX and treated with calcitonin showed significantly less cartilage degeneration and improved nociceptive tests compared with animals subjected to ACLT + OVX surgeries alone. Moreover, calcitonin increased TGF-β1 expression in chondrocytes in ACLT + OVX-affected cartilage. Subcutaneous injection of calcitonin (1) attenuated the development of OA, (2) concomitantly reduced nociception, and (3) modulated chondrocyte metabolism, possibly by increasing cellular TGF-β1 expression.

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Section: Discussionmentioning

confidence: 71%

“…OVX interferes with estrogen production and increases bone and cartilage turnover. OVX alone has been shown to produce signs of OA in rats 4 and to increase OA pathology in traumatic OA models in the rabbit 41 and rats 42 . The prevalence of OA is higher in post-menopausal women than in men 43 .…”

Section: Discussionmentioning

confidence: 99%

Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes

Wen

Tang

Chang

et al. 2016

Sci Rep

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“…Ovariectomy (OVX) in rats has been proposed as a model of postmenopausal OA although the changes in knee cartilage observed after OVX are relatively mild and cartilage turnover may be transient [41]. Nevertheless, the combination of ACLT and OVX in rats represents a model of OA and bone loss that may be useful to test chondroprotective interventions [42,43]. We have recently reported the suitability of this model for the evaluation of drugs targeting cartilage and bone alterations [44].…”

Section: Introductionmentioning

confidence: 99%

Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats

Terencio

Ferrándiz

Carceller

et al. 2016

Biomedicine & Pharmacotherapy

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“…Han et al (2007) reported that oyster shell increases the femur BMD and BV/TV in the OVX mice, indicating a potential for the cure of osteoporosis. Tibolone attenuated the development of osteoarthritis, concomitantly increasing serum ALP in the OVX-induced osteoporosis model (Yang et al 2014). This study revealed that PPE or Arg are able to successfully reduce the estrogen deficiency-induced bone loss.…”

Section: Discussionmentioning

confidence: 57%

Protective effect of porcine placenta in a menopausal ovariectomized mouse

et al. 2015

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Menopause is a significant physiological phase that occurs as women's ovaries stop producing ovum and the production of estrogen declines. Human placenta and some amino acids are known to improve menopausal symptoms. In this study, we investigated that porcine placenta extract (PPE) and arginine (Arg), a main amino acid of PPE, would have estrogenic activities in ovariectomized (OVX) mice as a menopause mouse model, human breast cancer cell line (MCF-7) cells, and human osteoblast cell line (MG-63) cells. PPE or Arg significantly inhibited the body weight and increased the vagina weight compared to the OVX mice. PPE or Arg ameliorated the vaginal atrophy in the OVX mice. The levels of 17b-estradiol and the activities of alkaline phosphatase (ALP) were significantly increased by PPE or Arg in the serum of OVX mice. Trabecular bone parameters such as bone mineral density and porosity were also improved by PPE or Arg in the OVX mice. In the MCF-7 and MG-63 cells, PPE or Arg significantly increased the cell proliferation, estrogen receptor b mRNA expression, and estrogen-response elements luciferase activity. Finally, PPE or Arg increased the activations of ALP and extracellular signalregulated kinase 1/2 in the MG-63 cells. These results indicate that PPE or Arg would have estrogenic and osteoblastic activity. Therefore, PPE or Arg may be useful as new pharmacological tools for treating menopausal symptoms including osteoporosis. Free Korean abstract: A Korean translation of this abstract is freely available at

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Effects of tibolone on osteoarthritis in ovariectomized rats: Association with nociceptive pain behaviour

Abstract: Treatment with tibolone attenuated the development of OA, concomitantly reduced nociception and increased serum alkaline phosphatase in ACLT + OVX rats.

Cited by 19 publications

References 52 publications

Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes

Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes

Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats

Protective effect of porcine placenta in a menopausal ovariectomized mouse

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