Effects of tocopherol supplementation on endometrial thickness in subfertility patients

Abstract

Background and Aim: Tocopherol is a vital nutrient for women during pregnancy, and multiple investigations revealed that a lack of tocopherol can cause preeclampsia, miscarriage, intrauterine growth restriction, and premature birth. There is scarcity of data regarding the effect of tocopherol on endometrial thickness. Therefore, the purpose of the present study was to assess the effect of tocopherol supplement on endometrial thickness. Methods: This randomized control clinical trial was conducted on 120 women with subfertility age group of 18 years to 37 years who visited the Obstetrics and Gynecology Department of Dr fida Painless Hospital Peshawar from January 2022 to June 2022. Patients were categorized into two groups: Group-I received Vit E supplements (800 IU) (n=60) and Group-II received placebo (n=60) for 12 weeks. The number of follicles and thickness of the endometrium were evaluated on ultrasound at day 2 and day 14. SPSS version 27 was used for data analysis. Results: The overall mean age of group I and II was 30.4±2.6 and 29.8±2.5 respectively. A significant difference was observed in mean endometrial thickness between groups I and II on day 2 (4.6 mm versus 3.3 mm) and day 14 (8.4 mm versus 5.8 mm) (P<0.001).