Effects of Tocotrienol-Rich Vitamin E on Patients with Peripheral Vascular Disease

Teoh, M. K.; Chong, M. K.; Jamaludin, Muhammad

doi:10.1007/978-3-0348-7432-8_48

Cited by 6 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tocopherols and tocotrienols capture and destroy damaging oxy free radicals that have been suggested to play a role in cellular aging, atherosclerosis, and cancer [50,[61][62][63]. Laboratory experiments on isolated rat hearts have shown that a tocopherol/ tocotrienol concentrate from palm oil is more efficient than α-tocopherol in protecting the heart against the oxidative injury usually associated with postsurgical flow of fresh blood into the affected organ [64][65][66][67].…”

Section: Tocopherols Tocotrienols and Carotenoidsmentioning

confidence: 99%

Palm Oil: A Healthful and Cost-Effective Dietary Component

2002

View full text Add to dashboard Cite

Palm oil is an excellent choice for food manufacturers because of its nutritional benefits and versatility. The oil is highly structured to contain predominantly oleic acid at the sn2-position in the major triacylglycerols to account for the beneficial effects described in numerous nutritional studies. Oil quality and nutritional benefits have been assured for the variety of foods that can be manufactured from the oil directly or from blends with other oils while remaining trans-free. The oxidative stability coupled with the cost-effectiveness is unparalleled among cholesterol-free oils, and these values can be extended to blends of polyunsaturated oils to provide long shelf-life. Presently the supply of genetic-modification-free palm oil is assured at economic prices, since the oil palm is a perennial crop with unparalleled productivity. Numerous studies have confirmed the nutritional value of palm oil as a result of the high monounsaturation at the crucial 2-position of the oil's triacylglycerols, making the oil as healthful as olive oil. It is now recognized that the contribution of dietary fats to blood lipids and cholesterol modulation is a consequence of the digestion, absorption, and metabolism of the fats. Lipolytic hydrolysis of palm oil glycerides containing predominantly oleic acid at the 2 position and palmitic and stearic acids at the 1 and 3 positions allows for the ready absorption of the 2-monoacrylglycerols while the saturated free fatty acids remain poorly absorbed. Dietary palm oil in balanced diets generally reduced blood cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides while raising the high-density lipoprotein (HDL) cholesterol. Improved lipoprotein(a) and apo-A1 levels were also demonstrated from palm oil diets; an important benefits also comes from the lowering of blood triglycerides (or reduced fat storage) as compared with those from polyunsaturated fat diets. Virgin palm oil also provides carotenes apart from tocotrienols and tocopherols that have been shown to be powerful antioxidants and potential mediators of cellular functions. These compounds can be antithrombotic, cause an increase of the prostacyclin/thromboxane ratio, reduce restenosis, and inhibit HMG-CoA-reductase (thus reducing) cholesterol biosynthesis). Red palm oil is a rich source of beta-carotene as well as of alpha-tocopherol and tocotrienols.

show abstract

Section: Tocopherols Tocotrienols and Carotenoidsmentioning

confidence: 99%

Palm Oil: A Healthful and Cost-Effective Dietary Component

2002

View full text Add to dashboard Cite

show abstract

“…Treatment of animals with vitamin E prevented bleomycininduced pulmonary fibrosis (69), adriamycininduced focal glomerulosclerosis (131), as well as oxygen-(59), ionophore-(134) and paraquatinduced lung toxicity in guinea pigs (116), presumably due to inhibition of endothelial cell damage and microvascular leakage (59,109). In the clinical setting, vitamin E has been found to significantly attenuate retinopathy and intraventricular hemorrhage in oxygen-ventilated babies (110), and to reduce the clinical manifestations of intermittent claudication in elderly human subjects (44,45,121). Intravital microscopic studies demonstrated that vitamin E prevents sunburn-associated leukocyte adhesion to venular endothelium and edema formation in mouse ears (125) and preserves microvascular perfusion after experimental gastric injury (74).…”

Section: Miscellaneous Models Of Diseasementioning

confidence: 99%

Vitamin E: Focus on Microcirculation

Lehr

VAJKOCZY

Menger³

1998

Microcirculation

View full text Add to dashboard Cite

Note. Vitamin E is the generic term for all tocopherols and tocotrienols having qualitatively the biological activity of RRRalpha-tocopherol (previously known as d-alpha-tocopherol). Alpha-tocopherol has the highest biological activity. Other major forms include beta-and gamma-tocopherol and alphatocotrienol. All-rac-alpha-tocopherol (previously known as dlalpha-tocopherol) is the synthetic form of vitamin E. Vitamin E activity in clinical trials has often been expressed as IU (International Units). One IU = 1 mg all-rac-alpha-tocopherol acetate = 0.74 mg RRR-alpha-tocopheryl acetate = 0.67 mg .

show abstract

“…Cellular damage due to lipid peroxidation causes serious derangements such as ischaemia-reperfusion injury (Omar et al, 1991), coronary arteriosclerosis (Jackson et al, 1993), diabetes mellitus (Sugawara et al, 1992) and neurodegenerative diseases (Simonian and Coyle, 1996) and is associated with aging (de Quiroga et al, 1992). Administration of antioxidants reduces or eliminates the biochemical and pathological changes brought about by lipid peroxidation (Teoh et al, 1992). Therefore, a number of synthetic and natural antioxidants have been developed for pharmaceutical uses (Andersson et al, 1996).…”

Section: Introductionmentioning

confidence: 98%

Antioxidative components of Psoralea corylifolia (Leguminosae)

Haraguchi

Inoue

Tamura³

et al. 2002

Phytotherapy Research

150

View full text Add to dashboard Cite

A meroterpene and four flavonoids were isolated from the seeds of Psoralea corylifolia as antioxidative components. Their structures were elucidated by spectral data and identified as bakuchiol (1), bavachinin (2), bavachin (3), isobavachin (4) and isobavachalcone (5). In particular, meroterpene 1 and flavonoids 4 and 5 showed broad antioxidative activities in rat liver microsomes and mitochondria. They inhibited NADPH-, ascorbate-, t-BuOOH- and CCl(4)-induced lipid peroxidation in microsomes. They also prevented NADH-dependent and ascorbate-induced mitochondrial lipid peroxidation. Bakuchiol (1) was the most potent antioxidant in microsomes and the inhibition of oxygen consumption induced by lipid peroxidation was time-dependent. Furthermore, bakuchiol (1) protected human red blood cells against oxidative haemolysis. These phenolic compounds in P. corylifolia were shown to be effective in protecting biological membranes against various oxidative stresses.

show abstract

Effects of Tocotrienol-Rich Vitamin E on Patients with Peripheral Vascular Disease

Cited by 6 publications

References 25 publications

Palm Oil: A Healthful and Cost-Effective Dietary Component

Palm Oil: A Healthful and Cost-Effective Dietary Component

Vitamin E: Focus on Microcirculation

Antioxidative components of Psoralea corylifolia (Leguminosae)

Contact Info

Product

Resources

About