Effects of Topical Retinoids on Acne and Post-inflammatory Hyperpigmentation in Patients with Skin of Color: A Clinical Review and Implications for Practice

Callender, Valerie D.; Baldwin, Hilary; Cook‐Bolden, Fran; Alexis, Andrew F.; Gold, Linda Stein; Guenin, Eric

doi:10.1007/s40257-021-00643-2

Cited by 45 publications

(50 citation statements)

References 34 publications

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“…To compare with gels, creams and lotions, gel is more stable and active than others, however, oil base gels are more irritant than water-based [5]. Benzoyl peroxide is a potent bactericidal mediator with a broad spectrum of activity due to its oxidizing activity [6]. In addition to having anti-inflammatory, keratolytic, and comedolytic properties, minor-to-temperate acne vulgaris is required to treat by the medication [7].…”

Section: Benzoyl Peroxidementioning

confidence: 99%

“…When treating mild-to-moderate acne, there has been a lot of agreement recently that topical retinoids should be the first thing people try. They can be used alone or in combination, and they are the most popular option in long-term care [6].…”

Section: B Topical Retinoidsmentioning

confidence: 99%

“…In vitro trials have shown that androgens such as testosterone and 5-DHT do not completely inhibit sebum synthesis [50]. They almost certainly need vivo cofactors, for example, peroxisome proliferator-activated receptor (PPAR) ligands, to exert their impact on the sebaceous gland [6,10]. Indeed, testimony recommends that other PPAR ligands, for instance, leukotriene B4 (LTB4), may also play a role in the progression of inflammatory acne wounds [51,52].…”

Section: Androgensmentioning

confidence: 99%

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Endocrine Disorders and Hormonal Therapy for Adolescent Acne

Assawaruangsin¹

2022

ijcsrr

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Acne vulgaris is a worldwide disease which is mostly found in teenagers. This has a crucial impact on their life’s quality, particularly when endocrine disorders have been implicated. Current consideration regarding antibiotic stewardship, failing with antibiotic utilization, and the improvement of antibiotic-resistant Propionibacterium acnes, there are many treatment alternatives for pimple therapy have been acknowledged. A following analysis investigates hormonal treatments for the therapy of acne vulgaris.

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Section: Benzoyl Peroxidementioning

confidence: 99%

Section: B Topical Retinoidsmentioning

confidence: 99%

Section: Androgensmentioning

confidence: 99%

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Endocrine Disorders and Hormonal Therapy for Adolescent Acne

Assawaruangsin¹

2022

ijcsrr

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, effective and timely AV treatment in patients with SoC is important owing to a heightened potential for sequelae, such as postinflammatory hyperpigmentation (PIH) and keloid development [ 3 – 5 ]. Topical retinoids may improve the appearance of pigmented lesions in patients with SoC [ 5 ]. Understanding these nuances in clinical presentation, safety considerations, cultural factors, and implications for treatment and skin care recommendations is important to ensure successful AV management in patients with SoC [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Trifarotene 0.005% Cream in the Treatment of Facial and Truncal Acne Vulgaris in Patients with Skin of Color: a Case Series

Rosso

Lain

York

et al. 2022

Dermatol Ther (Heidelb)

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The clinical appearance of acne vulgaris (AV) and the response to therapeutic agents may vary in people with skin of color (SoC) compared with those with lighter skin types. Given the heightened potential for postinflammatory hyperpigmentation and keloid development, effective and timely AV treatment in patients with SoC is especially important. However, these patients are frequently underrepresented in clinical trials, and SoC photographs are generally underrepresented in dermatology. Trifarotene 0.005% cream is a retinoid approved for the once-daily topical treatment of AV, and was studied in large-scale clinical trials that assessed the treatment of AV on both the face and trunk. For severe AV, a topical retinoid may be used in combination with an oral antibiotic, such as doxycycline. Five subjects covering Fitzpatrick skin phototypes III, IV, V, and VI were selected from two larger studies to visually demonstrate treatment of clinically diagnosed AV with trifarotene 0.005% cream. Two subjects received 24 weeks of treatment with trifarotene 0.005% cream for moderate AV on the face and trunk, while three subjects received 12 weeks of treatment with trifarotene 0.005% cream in association with 120 mg oral doxycycline with modified polymer coating for severe facial AV. This case series supports the favorable efficacy and safety of facial and truncal AV treatment with trifarotene 0.005% cream, with or without oral doxycycline, in subjects with SoC (phototypes III–VI).

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A practical guide to over‐the‐counter treatments for hyperpigmentation

Jafry,

Guan,

Mohammad

2024

JEADV Clinical Practice

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Hyperpigmentation of the skin, defined as increased melanin in the epidermis, is a common condition associated with psychosocial impairment and decreased quality of life. Prescription options are often not covered by insurance and can be cost prohibitive. As such, many turn to over‐the‐counter (OTC) products for treatment. However, a plethora of options are available, which can be confusing. This review aims to evaluate the evidence for common ingredients found in OTC products for management of hyperpigmentation and provide guidance for optimal use to clinicians and consumers. To perform this review, a comprehensive literature search utilizing PubMed and Google Scholar was conducted to identify relevant studies on the clinico‐epidemiological aspects of hyperpigmentation, including postinflammatory hyperpigmentation (PIH), melasma and maturational hyperpigmentation, as well as on relevant OTC treatments. The efficacy and safety of OTC products were assessed based on available evidence, clinical trials and expert recommendations. Our results showed hyperpigmentation is more prevalent among individuals with darker skin types (Fitzpatrick skin phototypes III–VI). Due to limited insurance coverage and the high cost of prescription options, over‐the‐counter (OTC) treatments are widely used for managing postinflammatory hyperpigmentation (PIH). However, the lack of strict regulation by the US Food and Drug Administration (FDA) raises concerns about the safety and efficacy of these products. By critically evaluating the existing literature, this review offers practical, evidence‐based guidance for the selection and utilization of OTC products for the treatment of hyperpigmentation.

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Effects of Topical Retinoids on Acne and Post-inflammatory Hyperpigmentation in Patients with Skin of Color: A Clinical Review and Implications for Practice

Cited by 45 publications

References 34 publications

Endocrine Disorders and Hormonal Therapy for Adolescent Acne

Endocrine Disorders and Hormonal Therapy for Adolescent Acne

Trifarotene 0.005% Cream in the Treatment of Facial and Truncal Acne Vulgaris in Patients with Skin of Color: a Case Series

A practical guide to over‐the‐counter treatments for hyperpigmentation

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