Effects of topical treatment of second-degree burn wounds with Lactobacillus acidophilus on the wound healing process in male rats

Barzegari, Amir Abbas; Hashemzaei, Masood; Majdani, Raheleh; Alihemmati, Alireza

doi:10.29252/pbr.3.3.23

Cited by 14 publications

(16 citation statements)

References 47 publications

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“…In this study, macroscopic and microscopic assessments of the wounds indicated that wound healing in the areas treated with L. plantarum were more than in the control and antibiotic groups. Previous research has shown that topical application of lactic acid bacteria as probiotic could prevent the colonization of pathogens and wound infection by different mechanisms [3,[29][30] associated with wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…Burn wounds are always a threat to human health and may lead to inability or even death [1] . Burn wound infections could cause tissue necrosis if not treated well [2][3] . Skin is a natural barrier to invasive pathogens.…”

Section: Introductionmentioning

confidence: 99%

“…In burns, the skin barrier is damaged, and the pathogens are ready to enter the wound and colonize it [2] . This is especially important when invaders are bacteria that are also resistant to antibiotics [3] . Some of the most common microorganisms colonizing and infecting burn wounds include Staphylococcus aureus, Pseudomonas aeruginosa, and fungal pathogens [4][5] .…”

Section: Introductionmentioning

confidence: 99%

“…Today, multidrug resistance in bacteria is a sever threat to public health worldwide, and the widespread use of antibiotics play a key role in the appearance of resistance [7] . Given the increase in antibiotic resistance and long duration of burn wound healing, it is important to find new methods such as bacterial therapy for treatment in order to be able to both prevent and heal wounds [3,6] and also to control drug-resistant infections and improve wound healing. The use of bacteria, especially probiotics, in the treatment of some diseases has attracted much attention [8][9] .…”

Section: Introductionmentioning

confidence: 99%

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Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats

moghaddam

Shabestari

Heidari

et al. 2020

IEM

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Burn infections are one of the most common causes of mortality in the world. On the other hand, microbial resistance to antibiotics has caused concern in the medical community. Therefore, controlling burn infections is very important, and using alternative therapies instead of antibiotics could be a good solution to this problem. Materials & Methods: Lactobacillus plantarum 299v strains were used in the experiments. Fifty male Wistar rats were prepared, and burn was induced in animals. The burn wounds were inoculated with clinical strains of MDR Pseudomonas aeruginosa in all animals and then treated daily with an eucerin ointment containing different compositions, including NaCl, imipenem, probiotic cell pellet, probiotic supernatant, and probiotic cell pellet + probiotic supernatant. The wound healing process was evaluated in animals after 7 days of treatment. Comparisons between different groups were performed using One-way ANOVA and Turkey's post hoc tests. Findings: After 7 days of treatment, the mean wound size in the probiotic cell pellet group was significantly lower than in the control and imipenem groups. Also, the mean wound size in the probiotic supernatant group was significantly lower than in the imipenem group. Histological parameters related to skin repair in the probiotic cell pellet group was better than in the control and antibiotic groups. Also, inflammation in the probiotic cell pellet group was less than in the control and imipenem groups. Conclusion:The macroscopic results of this study supported the microscopic results and showed that the mean size of the burn wounds in the probiotic cell pellet group was less than in the control and imipenem groups after 7 days of treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats

moghaddam

Shabestari

Heidari

et al. 2020

IEM

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“…In a rat model, wounds treated with L. acidophilus showed higher healing progress post-burn compared to Eucerin ointment. The L. acidophilus is believed to act via its anti-inflammatory action, accelerating the granulation tissue formation and re-epithelialization [109]. In diabetic foot ulcer (DFU) patients, kefir supplementation for 12 weeks led to a significant reduction in ulcer size [110].…”

Section: Wound Healingmentioning

confidence: 99%

The Many Faces of Kefir Fermented Dairy Products: Quality Characteristics, Flavour Chemistry, Nutritional Value, Health Benefits, and Safety

et al. 2020

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Kefir is a dairy product that can be prepared from different milk types, such as goat, buffalo, sheep, camel, or cow via microbial fermentation (inoculating milk with kefir grains). As such, kefir contains various bacteria and yeasts which influence its chemical and sensory characteristics. A mixture of two kinds of milk promotes kefir sensory and rheological properties aside from improving its nutritional value. Additives such as inulin can also enrich kefir’s health qualities and organoleptic characters. Several metabolic products are generated during kefir production and account for its distinct flavour and aroma: Lactic acid, ethanol, carbon dioxide, and aroma compounds such as acetoin and acetaldehyde. During the storage process, microbiological, physicochemical, and sensory characteristics of kefir can further undergo changes, some of which improve its shelf life. Kefir exhibits many health benefits owing to its antimicrobial, anticancer, gastrointestinal tract effects, gut microbiota modulation and anti-diabetic effects. The current review presents the state of the art relating to the role of probiotics, prebiotics, additives, and different manufacturing practices in the context of kefir’s physicochemical, sensory, and chemical properties. A review of kefir’s many nutritional and health benefits, underlying chemistry and limitations for usage is presented.

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Applications of Synbiotics as Cosmeceuticals

Yadav,

Sapra

2024

Synbiotics in Human Health: Biology to Drug Delivery

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Effects of topical treatment of second-degree burn wounds with Lactobacillus acidophilus on the wound healing process in male rats

Cited by 14 publications

References 47 publications

Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats

Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats

The Many Faces of Kefir Fermented Dairy Products: Quality Characteristics, Flavour Chemistry, Nutritional Value, Health Benefits, and Safety

Applications of Synbiotics as Cosmeceuticals

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