Effects of trace elements on membrane fluidity

Garcia, J.; Martı́nez-Balları́n, Enrique; Millán-Plano, Sergio; Allué, J.L.; Calleja, Carlos David Albendea; Fuentes, L.; Escanero, J.F.

doi:10.1016/j.jtemb.2005.07.007

Cited by 76 publications

(48 citation statements)

References 31 publications

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“…Findings from these ongoing Cr 3+ studies are anticipated to shed new insight into the mechanism of action of this transition metal. Interestingly, it is very possible that the interaction of heavy metals with cellular membranes may contribute to, at least partially, the toxicity associated with these metals [49]. For example, cell membranes are dynamic, fluid structures, and most of their molecules are able to move in the plane of the membrane.…”

Section: Discussionmentioning

confidence: 99%

Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions

Pattar

Tackett

Liu

et al. 2006

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Since trivalent chromium (Cr 3+ ) enhances glucose metabolism, interest in the use of Cr 3+ as a therapy for type 2 diabetes has grown in the mainstream medical community. Moreover, accumulating evidence suggests that Cr 3+ may also benefit cardiovascular disease (CVD) and atypical depression. We have found that cholesterol, a lipid implicated in both CVD and neurodegenerative disorders, also influences cellular glucose uptake. A recent study in our laboratory shows that exposure of 3T3-L1 adipocytes to chromium picolinate (CrPic, 10 nM) induces a loss of plasma membrane cholesterol. Concomitantly, accumulation of intracellularly sequestered glucose transporter GLUT4 at the plasma membrane was dependent on the CrPic-induced cholesterol loss. Since CrPic supplementation has the greatest benefit on glucose metabolism in hyperglycemic insulin-resistant individuals, we asked here if the CrPic effect on cells was glucose-dependent. We found that GLUT4 redistribution in cells treated with CrPic occurs only in cells cultured under high glucose (25 mM) conditions that resemble the diabetic-state, and not in cells cultured under non-diabetic (5.5 mM glucose) conditions. Examination of the effect of CrPic on proteins involved in cholesterol homeostasis revealed that the activity of sterol regulatory element-binding protein (SREBP), a membrane-bound transcription factor ultimately responsible for controlling cellular cholesterol balance, was upregulated by CrPic. In addition, ABCA1, a major player in mediating cholesterol efflux was decreased, consistent with SREBP transcriptional repression of the ABCA1 gene. Although the exact mechanism of Cr 3+ -induced cholesterol loss remains to be determined, these cellular responses highlight a novel and significant effect of chromium on cholesterol homeostasis. Furthermore, these findings provide an important clue to our understanding of how chromium supplementation might benefit hypercholesterolemia-associated disorders.

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Section: Discussionmentioning

confidence: 99%

Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions

Pattar

Tackett

Liu

et al. 2006

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…Additionally, it has been suggested that chromium supplementation increases membrane fluidity (31,50), resulting in increased glucose uptake.…”

Section: Mechanismsmentioning

confidence: 99%

Chromium chloride increases insulin‐stimulated glucose uptake in the perfused rat hindlimb

et al. 2014

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Aim To determine the effect of chromium chloride (CrCl3) on healthy skeletal muscle glucose uptake in the absence and presence of submaximal insulin using the rat hindlimb perfusion technique. Methods Sprague–Dawley rats were randomly assigned to an experimental group: basal (Bas), chromium chloride (Cr), submaximal insulin (sIns) or chromium chloride plus submaximal insulin (Cr‐sIns). Results Insulin significantly increased [H3]‐2 deoxyglucose (2‐DG) uptake in the gastrocnemius muscles. Additionally, Cr‐sIns displayed greater rates of 2‐DG uptake than sIns (Cr‐sIns 6.86 ± 0.74 μmol g h−1 vs. sIns 4.83 ± 0.42 μmol g h−1). There was no difference between Cr and Bas treatment groups. It has been speculated that chromium works to increase glucose uptake by increasing insulin signalling. We found that Akt and AS160 phosphorylation was increased in the sINS treatment group, while chromium treatment had no additional effect on Akt or AS160 phosphorylation in the absence or presence of insulin. Cr‐sIns significantly increased plasma membrane GLUT4 concentration above that of sIns (Cr‐sIns 72.22 ± 12.7%, sIns 53.4 ± 6.1%), but in the absence of insulin, chromium had no effect. Conclusion Exposure of healthy skeletal muscle to chromium may increase skeletal muscle insulin‐stimulated GLUT4 translocation and glucose uptake. However, these effects do not appear to result from enhanced insulin signalling proximal to AS160.

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“…A better patency of substances through the cytoplasmic membrane can be also included among these effects. In this case, the fermentation speed is limited by the saccharides transport [22] and protein synthesis, which includes the synthesis of the alcoholdehydrogenesis enzyme [23]. The opposite effect has been observed in low zinc content malts that are sometimes called "sluggish" in practice and in extreme cases, a premature yeast flocculation may occur [24].…”

Section: Poděkovánímentioning

confidence: 99%

“…Lze sem zahrnout také efekt větší průchodnosti látek cytoplazmatickou membránou. Zde je pro rychlost fermentace limitující transport sacharidů [22] a syntéza bílkovin, kam patří syntéza enzymu alkoholdehydrogenasy [23]. Opačný efekt je pozorován u sladin s nízkým obsahem zinku, které se v praxi nazývají jako "loudavé", a v extrémním případě může nastat i předčasná flokulace kvasnic [24].…”

Section: Vliv Zinku Na Průběh Kvašení Sladinyunclassified

Zinc - effect on the spring barleyʼs plant and roots growth, grain technological quality, and yeast fermentation.

Cerkal¹,

Hřivna²,

Ryant³

et al. 2010

Kvasny Prum

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152Zinek -vliv na růst rostlin a kořenů ječmene, technologickou kvalitu zrna a kvašení sladiny Zinek -vliv na růst rostlin a kořenů ječmene, technologickou kvalitu zrna a kvašení sladiny Zinc -effect on the spring barley's plant and roots growth, grain technological quality, and yeast fermentation RADIM ) na velikost kořenového systému rostlin (měřena jeho elektrická kapacita v DC 23 a 57), výnos a kvalitu zrna a průběh kvašení sladiny u šesti odrůd ječmene jarního (Bojos, Jersey, Kompakt, Malz, Sebastian, Tolar). V působení zinku na rozvoj kořenového systému se prokázaly odrůdové diference. Výnos zrna se po aplikaci zvýšil v průměru o 3 %, vzrostl podíl přepadu zrna na sítě 2,5 mm (o 9 %) a hmotnost tisíce zrn (o téměř 2 %). Aplikace zinku vedla k vyšší syntéze škrobu v zrnu, hodnoty obsahu extraktu narostly o 0,3-0,5 %. Po ošetření porostů zinečnatým hnojivem se zvýšil obsah nativního obsahu zinku v zrnu o 3-11 %. Výno-sem zrna ječmene bylo průměrně odčerpáno 143 g.ha -1 zinku (od 126 g.ha -1 -Kompakt do 159 g.ha -1 -Bojos). Vyšší odběr zinku byl zaznamenán u porostů po foliární aplikaci zinečnatého hnojiva (o 10-17 %). Byla prokázána negativní korelace obsahu zinku s obsahem N látek v zrnu (od r = -0,274 do -0,525**) a pozitivní vztah tohoto mikroelementu s obsahem škrobu (r = 0,014 až 0,367*). Pozitivní závislosti byly zjištěny ve vztahu obsahu zinku a friability (r = 0,329*-0,691***), resp. USJ (r = 0,274-0,603***), negativní naopak k obsahu β-glukanů v zrnu (r = -0,265 až -0,521**). U variant hnojených zinkem byly prokázány rychlejší procesy fermentace sladiny v prvních 24 hodinách (o 1-1,5 %), na výsledné hloubce prokvašení se tato skutečnost neprojevila (diference mezi kontrolní a ošetře-nými variantami byla 0,1 %).Cerkal, R. -Hřivna, L. -Ryant, P. -Prokeš, J. -Březinová Belcredi, N. -Vejražka, K. -Michnová, M. -Gregor, T.: Zinc -effect on the spring barleyʼs plant and roots growth, grain technological quality, and yeast fermentation. Kvasny Prum. 56, 2010, No. 3, p. 152-159. In 2005, the effect of zinc foliar application (0.5 kg.ha -1 in DC 31 and 55 growth stage in the form of the Zinran fertilizer containing sulphate and zinc oxide -19.8 and 52.3 %) on the size of the plants root system (its electric capacity in DC 23 and 57 was measured), the yield and quality of grain, and the course of the sweet wort fermentation process of six spring barley varieties (Bojos, Jersey, Kompakt, Malz, Sebastian, Tolar) was studied. Varietal differences were found in regard to the impact of zinc on the root system development. The grain yield rose by 3% on average after zinc application and so did grain over sieve 2.5 mm (by 9%) and weight of thousand grains (by almost 2%). Zinc application led to a higher starch synthesis in the grain, the extract content values increased by 0.3-0.5%. After the zinc fertilizer treatment, the native zinc content in grain increased by 3-11%. On average, 143 g.ha -1 was taken up by the grain yield (from 126 g.ha -1 -Kompakt to 159 g.ha -1 -Bojos), a higher uptake was observed in stan...

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Effects of trace elements on membrane fluidity

Cited by 76 publications

References 31 publications

Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions

Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions

Chromium chloride increases insulin‐stimulated glucose uptake in the perfused rat hindlimb

Zinc - effect on the spring barleyʼs plant and roots growth, grain technological quality, and yeast fermentation.

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