Effects of tracheal occlusion with retinoic acid administration on normal lung development

Delabaere, Amélie; Marceau, Geoffroy; Coste, Karen; Blanchon, Loı̈c; Déchelotte, Pierre-Jean; Sapin, Vincent; Gallot, Denis

doi:10.1002/pd.5012

Cited by 4 publications

(6 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 In normal lungs, it contributed to increased SP-B expression, which decreased after TO creation. 38 In a previous study of pulmonary effects of maternal administration of RA, 18 we found that RA did not affect gross cell anatomy, morphology, proliferation, or apoptosis indexes in hypoplastic DH lungs.…”

Section: Pulmonary Gene Expression Levels Of Ednramentioning

confidence: 69%

“…In DH lungs, it contributed to a decrease in PE type II density and surfactant production, which increased after DH creation . In normal lungs, it contributed to increased SP‐B expression, which decreased after TO creation …”

Section: Discussionmentioning

confidence: 99%

“…As mentioned before, potential advantages of tracheal RA include reduced systemic maternal RA diffusion and potentiation of fetal pulmonary effects. We previously demonstrated that liposomes served as a good vehicle for delivering RA in the trachea and that the surfactant protein B (SP‐B) expression increased after intratracheal RA and TO in normal lungs …”

Section: Introductionmentioning

confidence: 99%

“…We previously demonstrated that liposomes served as a good vehicle for delivering RA in the trachea and that the surfactant protein B (SP-B) expression increased after intratracheal RA and TO in normal lungs. 38 The main objective of this study was to evaluate the effects of a combination of TO and intratracheal RA administration on pulmonary maturation and vascularization in a fetal rabbit DH model.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Retinoic acid and tracheal occlusion for diaphragmatic hernia treatment in rabbit fetuses

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Pulmonary Gene Expression Levels Of Ednramentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Retinoic acid and tracheal occlusion for diaphragmatic hernia treatment in rabbit fetuses

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…136 To study the effects of topical administration of ATRA, Delabaere et al also showed that intratracheal injection of ATRA decreased pulmonary arterial reactivity, restored alveolar type II cell differentiation, and stimulated surfactant production. 137,138 To improve the feasibility of TO in humans, Muensterer et al used the rabbit model to test a gel plug as a temporary TO as an alternative to the balloon in fetal rabbits. 139,140 Jani et al studied ventilation of rabbits with CDH and TO, and reported that lung mechanics did not change after TO despite having a substantial effect on lung extracellular matrix components, pointing to the fact that the effect of TO was predominately caused by airway remodeling and reduced airway resistance.…”

Section: Interventions Tested Using the Rabbit Modelmentioning

confidence: 99%

Congenital Diaphragmatic Hernia: State of the Art in Translating Experimental Research to the Bedside

et al. 2019

View full text Add to dashboard Cite

Congenital diaphragmatic hernia (CDH) is a devastating disease that still carries a high mortality and morbidity rate. Poor outcomes for fetuses and infants with CDH are mainly related to pulmonary hypoplasia (PH) and pulmonary vascular remodeling that leads to pulmonary hypertension (PHTN). Over the last five decades, research efforts have focused on modeling CDH not only to study the pathophysiology of the diaphragmatic defect, pulmonary hypoplasia, and pulmonary hypertension, but also to identify therapies that would promote lung growth and maturation, and correct vascular remodeling. As CDH is a multifactorial condition whose etiology remains unknown, there is not a single model of CDH, rather several ones that replicate different aspects of this disease. While small animals like the mouse and the rat have mainly been used to uncover biological pathways underlying the diaphragmatic defect and poor lung growth, larger animals like the lamb and the rabbit models have been instrumental for pursuing medical and surgical interventions. Overall, the use of animal models has indeed advanced our knowledge on CDH and helped us test innovative therapeutic options. For example, the lamb model of CDH has been the paradigm for testing fetal surgical procedures, including tracheal occlusion, which has been translated to clinical use. In this review, we outline the induction protocols of CDH in animals with the use of chemicals, dietary changes, genetic alterations, and surgical maneuvers, and we describe the studies that have translated experimental results to the bedside.

show abstract

Antenatal Medical Therapies to Improve Lung Development in Congenital Diaphragmatic Hernia

et al. 2018

View full text Add to dashboard Cite

Congenital diaphragmatic hernia (CDH) is a birth defect characterized by failed closure of the diaphragm, allowing abdominal viscera to herniate into the thoracic cavity and subsequently impair pulmonary and vascular development. Despite improving standardized postnatal management, there remains a population of severe CDH for whom postnatal care falls short. In these severe cases, antenatal surgical intervention (fetoscopic endoluminal tracheal occlusion [FETO]) may improve survival; however, FETO increases the risk of preterm delivery, is not widely offered, and still fails in half of cases. Antenatal medical therapies that stimulate antenatal pulmonary development are therefore interesting alternatives. By presenting the animal research underpinning novel antenatal medical therapies for CDH, and considering the applications of these therapies to clinical practice, this review will explore the future of antenatal CDH management with a focus on the phosphodiesterase-5 inhibitor sildenafil.

show abstract

Effects of tracheal occlusion with retinoic acid administration on normal lung development

Abstract: We established the potential of liposome and Miglyol as RA vehicle for delivering this bioactive molecule in the fetal airways. Tracheal RA injection seems to oppose the effects of TO in fetuses with normal lungs. © 2017 John Wiley & Sons, Ltd.

Cited by 4 publications

References 46 publications

Retinoic acid and tracheal occlusion for diaphragmatic hernia treatment in rabbit fetuses

Retinoic acid and tracheal occlusion for diaphragmatic hernia treatment in rabbit fetuses

Congenital Diaphragmatic Hernia: State of the Art in Translating Experimental Research to the Bedside

Antenatal Medical Therapies to Improve Lung Development in Congenital Diaphragmatic Hernia

Contact Info

Product

Resources

About