Effects of traditional Chinese herbal medicine San-Huang-Xie-Xin-Tang on gastrointestinal motility in mice

Hwang, Min-Woo; Ahn, Tae-Seok; Hong, Noo Ri; Jeong, Hyein; Jung, Myeong Ho; Ha, Ki‐Tae; Kim, Byung Joo

doi:10.3748/wjg.v21.i4.1117

Cited by 16 publications

(6 citation statements)

References 40 publications

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“…However, they have significant gastrointestinal intolerance , nightmare and other undesirable side effects. Therefore, during the past few decades, many researchers have focused on the expansion of traditional herb medicines such as San‐Huang‐Xie‐Xin‐Tang and Huang‐Lian‐Jie‐Du‐Tang due to their lasting efficacies and few side effects in the treatment of T2DM, and these multi‐herb prescriptions often include special herb pair such as Scutellariae Radix (SR) and Coptidis Rhizoma (CR). Herb pairs are much simpler than complicated multi‐herb prescriptions and retain the basic therapeutic features.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the main active components and hypoglycemic effects after the compatibility of Scutellariae Radix and Coptidis Rhizoma

Cui

Shen

Jiang

et al. 2019

J of Separation Science

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In this study, a rapid and highly sensitive ultra high performance liquid chromatography with triple quadrupole mass spectrometry method with the mobile phase of acetonitrile and 0.1% aqueous formic acid was established and successfully applied to comparatively analyze main active components after their compatibility. Besides, the effects of Scutellariae Radix, Coptidis Rhizoma and combined extracts on type 2 diabetic rats induced by high-fat diet along with low dose of streptozocin were investigated. Under the optimized chromatographic conditions, good separation of seven target components was achieved within 12 min. All calibration curves exhibited good linearity (R 2 ≥ 0.999). The relative standard deviation of precision, repeatability and stability varied from 0.69 to 2.23, 0.98 to 2.56, and 0.92 to 2.57%, respectively. The recovery ranged from 91.11 to 105.35%. The contents of seven active components were notably reduced after compatibility; however, the hypoglycemic effect of combined extracts was stronger than single drug by decreasing the activities of fructose-1,6-bisphosphatase, glucose 6-phosphatase, phosphoenolpyruvate carboxykinase and increasing the activities of glucokinase, phosphofructokinase, pyruvate kinase. Accordingly, the established analytical method was accurate and sensitive enough for quantitative evaluation of seven investigated compounds. Moreover, the combined extract had definite effects on type 2 diabetes through multiple components against multiple targets.

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of the main active components and hypoglycemic effects after the compatibility of Scutellariae Radix and Coptidis Rhizoma

Cui

Shen

Jiang

et al. 2019

J of Separation Science

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“…Hwang-Geum, the roots of Scutellaria baicalensis (Lamiaceae), and Hwang-Ryeon, the rhizomes of Coptis chinensis (Ranunculaceae), have been traditionally used to treat pathological heatmediated symptoms, such as fever, anxiety, insomnia, frequent hunger, mouth dryness and thirst, bleeding, skin spots and folliculitis. [1][2][3][4] Herbal formulas containing S. baicalensis and C. chinensis have been shown to have antitumor, [5,6] hepatoprotective, [7] anti-inflammatory, [8] anti-allergy, [9] antihyperlipidemia, [10] anti-hyperglycemia, [11] and central nervous system disorder-relieving effects, [12] as well as anti-infection [13] and microbiota modulation properties. [14] The formation of precipitate was observed in the hot water extract of the S. baicalensis-C. chinensis pair.…”

Section: Introductionmentioning

confidence: 99%

Chemical Characterization of the Precipitate Found in and Its Effect on Drug Release of the Scutellaria baicalensis‐Coptis chinensis Extract

Kim,

Kim

2023

Chemistry & Biodiversity

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Precipitate generation is a challenging issue during the production of herbal decoction as it affects the stability and bioavailability of active compounds. Here we explored the composition of the natural precipitate formed from and its effect on drug release of Scutellaria baicalensis–Coptis chinensis paired extract (SCPE). Furthermore, the surface morphology of the SCPE precipitate was also investigated. Ultra‐performance liquid chromatography‐mass spectrometry (UPLC‐MS) was used to chemical component analysis and field emission scanning electron microscope (FE‐SEM) was performed to particle observation. Baicalin (BA), berberine (BBR) and starch‐arginine‐rich polymers were abundant in the SCPE precipitate. FE‐SEM micrographs showed spheroidal shaped particles in the SCPE supernatant, while spherical and porous tissue‐shaped particles in the SCPE precipitate. In vitro drug release of baicalin and berberine contained in the precipitate may increase as the polymer is removed. The presence of polymer‐related interactions were confirmed by the greater increase in solubility of baicalin upon addition of arginine and polymer. This was also supported by the solubility decrease of the BA‐BBR complex in polymer solution and the gelation of the BA‐BBR complex in arginine solution. Our results provide a scientific basis for elucidating the pharmaceutical properties of the decoction of S. baicalensis–C. chinensis ‐ based herbal medicine.

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“…Although western medicine treatment can achieve certain effects in clinical practice, the overall effect is still not satisfactory. As one of China's traditional medical treasure houses, traditional Chinese medicine has unique advantages in the treatment of gastrointestinal diseases [ 6 – 8 ]. Tong-Xie-Yao-Fang (TXYF) is one of the classic prescriptions of traditional Chinese medicine, which consists of four herbal drugs: Rhizoma Atractylodis Macrocephalae , Radix Paeoniae Alba , Pericarpium Citri Reticulatae , and Radix Saposhnikoviae .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Compound Herbal Medicine Tong-Xie-Yao-Fang for Acute Radiation Enteritis and Its Potential Mechanisms: Evidence from Transcriptome Analysis

Yang

Xia

et al. 2020

BioMed Research International

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Acute radiation enteritis (ARE) is a common complication with radiotherapy for pelvic and abdominal malignancy. This research is designed to investigate the efficacy of Tong-Xie-Yao-Fang (TXYF) on ARE and to explore the underlying mechanisms by microarray analysis. The ARE rat model was established by a single abdominal irradiation with a gamma-ray dose of 10 Gy. Next, the ARE rats were treated with distilled water, TXYF, and glutamine by gavage for 7 consecutive days according to the scheduled groups. For each group, the jejunal tissue was taken at 6 h after gastric lavage. The morphology of intestinal tissue was observed by hematoxylin and eosin (H&E) stain under a light microscope. The height of the villus and the thickness of the whole layer of the TXYF-treated groups were significantly ameliorative than that of the model control group. The transcriptome analysis was produced using the Agilent SurePrint G3 Rat GE V2.0 microarray. A total of 90 differentially expressed genes (DEGs), including 48 upregulated genes and 42 downregulated genes, were identified by microarray and bioinformatics analysis. Protein–protein interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) were conducted to explore the possible mechanisms of DEGs taking part in the TXYF-mediated therapeutic process for ARE. In conclusion, we reveal that TXYF has a protective effect on the intestinal tissue of rats with ARE and summarize several DEGs, suggesting the possible mechanisms of TXYF-mediated efficacy for ARE.

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Effects of traditional Chinese herbal medicine San-Huang-Xie-Xin-Tang on gastrointestinal motility in mice

Abstract: These results suggest that SHXXT is a novel candidate for the development of a prokinetic agent that may prevent or alleviate GMD.

Cited by 16 publications

References 40 publications

Comparative analysis of the main active components and hypoglycemic effects after the compatibility of Scutellariae Radix and Coptidis Rhizoma

Comparative analysis of the main active components and hypoglycemic effects after the compatibility of Scutellariae Radix and Coptidis Rhizoma

Chemical Characterization of the Precipitate Found in and Its Effect on Drug Release of the Scutellaria baicalensis‐Coptis chinensis Extract

Efficacy of Compound Herbal Medicine Tong-Xie-Yao-Fang for Acute Radiation Enteritis and Its Potential Mechanisms: Evidence from Transcriptome Analysis

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