Effects of tramadol on synovial fluid concentrations of substance P and interleukin-6 in patients with knee osteoarthritis: comparison with paracetamol

Bianchi, Mauro; Broggini, M.; Balzarini, P.; Baratelli, E; Ferrario, P.; Panerai, Alberto E.; Sacerdote, Paola

doi:10.1016/j.intimp.2003.08.011

Cited by 34 publications

(28 citation statements)

References 33 publications

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“…In our study we determined highly significant increases in IL-6 and IL-8 concentrations from the first hour and a half of sampling to the second hour and a half of sampling; regardless of exercise and position of the catheter (Figure 3). Our levels reached medians of approximately 600 pg/ml and 5,000 pg/ml for each of the sampling periods irrespective of the position of the catheter, which contrasts with the findings of other investigators, who discovered levels of IL-6 and IL-8 in synovial fluid obtained by direct joint puncture of approximately 50 to 200 pg/ml [11,26,27]. A major trauma to the knee such as a tear of the anterior cruciate ligament has been found to result in IL-6 levels above 20,000 pg/ml within the first couple of days [28], and as the concentrations in the present study increased over time our findings could indicate that the insertion of the catheters per se induced a production of these cytokines due to the tissue injury.…”

Section: Discussioncontrasting

confidence: 99%

Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial

et al. 2010

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IntroductionThe microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in response to a single bout of mechanical joint loading.MethodsThirty-one female subjects with OA of the knee were randomized to non-exercise (NEx) or exercise (Ex) groups. Following acute resistance exercise (25 sets of 10 repetitions at 60% of 1 Repetition Maximum) or none (NEx), peripheral nerve blocks just below the inguinal ligament were applied and two microdialysis catheters were positioned in two different compartments, intraarticularly and peri-synovially. The microdialysis catheters were perfused at a slow rate (2 μl/minute) with a solution of Ringer-acetate and radioactively labelled glucose allowing for determination of relative recovery (RR) and calculation of interstitial concentrations of inflammatory and cartilage biomarkers over a three-hour period.ResultsA significant increase of Interleukin (IL) -10 was discovered in both positions of the knee in the Ex group over the three hours post exercise, whereas IL-10 remained stationary over time in the NEx group. IL-6 and IL-8 displayed significant increases over time regardless of group and position of the catheter. Cartilage oligomeric matrix protein (COMP) decreased intraarticularly in the post exercise period in the Ex group compared to the NEx group.ConclusionsExercise caused an increase in both intraarticular and peri-synovial concentrations of IL-10 in a group of human females with knee OA. This suggests a positive effect of exercise on a chondroprotective anti-inflammatory cytokine response in patients with knee OA and might contribute to explaining the beneficial effect that exercise has on OA.Trial registrationNCT01090375.

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Section: Discussioncontrasting

confidence: 99%

Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial

et al. 2010

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“…To our knowledge, the eVect of exercise on SF levels of IL-6 has not previously been investigated. One previous study has failed to detect IL-6 in healthy knees of young subjects [23], and others have demonstrated levels in patients with OA of the knee [24,25] comparable to ours. On this basis, it does not seem that the exercise protocol in this study was strong enough to initiate any changes in IL-6, but perhaps, a more strenuous protocol would have caused an increase.…”

Section: Discussionsupporting

confidence: 87%

Moderate loading of the human osteoarthritic knee joint leads to lowering of intraarticular cartilage oligomeric matrix protein

et al. 2011

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The non-pharmacological treatment of osteoarthritis (OA) includes exercise therapy; however, little is known about the specific effect of exercise on the joint per se. The purpose of the present study was to investigate the direct effects of a load-bearing exercise upon cartilage in a single, human osteoarthritic joint determined by biochemical markers of cartilage turnover and inflammation in the synovial fluid (SF), serum and urine. Eleven subjects with OA of the knee(s), but with no other joint- or inflammatory disorders, volunteered for the study and had samples of blood, urine and synovial fluid drawn both at baseline and following 30-min one-legged knee-extension exercise. Workload: 60% of 1 RM (Repetition Maximum). Determination of cartilage oligomeric matrix protein (COMP), aggrecan, C-terminal collagen II peptide (CTX-II) and interleukin (IL)-6 were performed in synovial fluid (SF), serum and urine. A significant decrease was found in SF concentration of COMP following exercise, whereas aggrecan, CTX-II and IL-6 remained unchanged. No differences in any of the tested markers were found in serum and urine between baseline and post-exercise. Thirty minutes of mechanical loading of a single knee joint in human subjects with knee OA resulted in a reduced COMP concentration in SF.

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“…Clinical studies have confirmed the analgesic efficacy of the tramadol after intraarticular administration in human and it is documented that morphine and tramadol, at the doses used, provide similar analgesia when given intraarticularly, so tramadol can be an alternative to morphine for postoperative analgesia after arthroscopic surgery (Akinci et al, 2005). Reduced intensity of joint pain and significant reduction of synovial fluid concentration of substance P (which is involved in joint damage, inflammation and pain) is revealed in tramadol treated patients with knee osteoarthritis by (Bianchia et al, 2003).…”

Section: Discussionmentioning

confidence: 91%

Effects of Intraarticular Tramadol Administration on Biochemical and Cytological Properties of Equine Synovial Fluid: Comparison with Lidocaine

Jahromi¹

2011

American Journal of Pharmacology and Toxicology

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Problem statement: Diagnostic and therapeutic arthroscopic surgeries are procedures performed quite frequently in equine practice; and are considered to cause some degree of postoperative pain. The aim of the present study was to evaluate the equine synovial fluid biochemical and cytological changes following intra-articular administration of tramadol as a potential analgesic. Approach: Six adult healthy donkeys were selected after clinical examination. Synovial fluid samples were taken from both middle carpal joints after routine preparation. Tramadol 2 mg kg −1 and 100 mg lidocaine 2% were administered to the right and left joints respectively. Synovial fluid collection from the joints was performed at 12, 24, 48-192 h after medication. Cytological examination, total protein, glucose, specific gravity, Alkaline Phosphates (ALP), Aspartate Aminotransferase (AST), Lactate Dehydrogenase (LDH), viscosity and quality of mucin clot were measured. Comparison of treatments was performed by nonparametric sign test and Wilcoxon rank sum test. Significance level was set to p ≤ 0.05. Results: Neither detectable lameness nor special side effect was observed throughout the study. Mucin clot quality test and viscosity, the amount of total nucleated cell count, glucose, ALP and LDH revealed no significant differences between various sampling times between the tramadol and lidocaine groups (P>0.05). Neutrophil count, total protein, specific gravity and AST activity were significantly different. Conclusion/Recommendations: Despite the slightly different results compared to the lidocaine, it seems that the injection of tramadol into the middle carpal joint has no adverse effects on the synovial fluid composition in this joint and it can be considered a good analgesic after arthroscopic surgery with the lowest side effects in horses.

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Effects of tramadol on synovial fluid concentrations of substance P and interleukin-6 in patients with knee osteoarthritis: comparison with paracetamol

Cited by 34 publications

References 33 publications

Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial

Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial

Moderate loading of the human osteoarthritic knee joint leads to lowering of intraarticular cartilage oligomeric matrix protein

Effects of Intraarticular Tramadol Administration on Biochemical and Cytological Properties of Equine Synovial Fluid: Comparison with Lidocaine

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