Effects of Trans-Cinnamaldehyde on Reperfused Ischemic Skeletal Muscle and the Relationship to Laminin

Pekoğlu, Esra; Büyükakıllı, Belgin; Turkseven, Cagatay Han; Ballı, Ebru; Bayrak, Gülşen; Çimen, Burak; Balcı, Şenay

doi:10.1080/08941939.2020.1802538

Cited by 3 publications

(10 citation statements)

References 37 publications

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“…18 studies used rats in their experimental design. Of these 18 studies, nine articles used Sprague-Dawley rats [23][24][25][26][27][28][29][30][31], one used Wistar albino rats [32], seven studies used Lewis rats [33][34][35][36][37][38][39], and one study used Fisher rats [40]. Five of the 29 articles used mice in their experimental design.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Ischemia and I/R models were used for all the included studies (Table 1). These studies used either elastic non-pneumatic tourniquet [26,27,29,32,40,49], pneumatic tourniquet [23,31,33,34,[41][42][43], atraumatic clamps [24,25,28,[46][47][48]51], or ligation methods [30,39,44,45] to produce ischemia in the hind limbs. Specifically, four of the studies amputated the thigh sparing femoral vessels, later femoral vessels were occluded to avoid venous congestion and create ischemia [35][36][37][38].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…To induce anesthesia, ten studies used isoflurane [23,28,33,34,39,[41][42][43][44][45], seven studies used nembutal [24,25,[35][36][37][38]50], four studies used ketamine and xylazine [29,31,32,40],…”

Section: Study Characteristicsmentioning

confidence: 99%

“…PLOS ONE 1. The route of administration for these interventions were intravenous infusions (n = 4) [23,24,37,38], intravenous (n = 9) [26,28,31,35,36,41,46,48,49], intramuscular (n = 8) [25,33,34,39,[42][43][44][45], intraperitoneal (n = 1) [40], intraperitoneal infusion (n = 1) [32], local application (n = 1) [51], intra-arterially one-time bolus plus infusion (n = 1) [47], and gavage (n = 2) [27,29]. Duration of treatment ranged from 30 mins to 6.5 hrs in eight studies [23,24,26,32,37,38,46,50], in 15 studies a single bout of treatment was used [25, 28, 31, 33-36, 39, 41-45, 48, 51], one study used a one-time bolus followed by 60 mins of infusion [47], one-time treatment was used every day for 7 days [40] or for 5 days [27], three times treatment with two hour intervals [49] or 8 hour interval [29] was used, and the drug was given in 0.5 ml increments over 5 min interval for 1 hour [30] (Table 1).…”

Section: In-vivomentioning

confidence: 99%

“…Out of the 29 studies, 11 reported inflammatory results (Table 2). Out of the 11 studies which reported inflammatory results, one study reported the inhibition of inflammation based on histological analysis of inflammatory cells such as, neutrophils, lymphocytes, and macrophages [23], one study reported the drug effects on inflammation based on microscopic observations (no details on how these observations were made are reported) [24], two studies reported inhibition of inflammation based on histology analysis of neutrophil infiltration alone [25,36], and of the remaining six studies, two reported results based on CD68 immunoreactivity indicative for macrophage infiltration [33,48], two studies from the same group [26,27] and one other study [29] employed myeloperoxidase activity as a marker of skeletal muscle neutrophil infiltration to study inflammation, and the remaining study analyzed stained tissue for cellular inflammation with no specifics on the type of inflammatory cells [35], and one study analyzed inflammasome pathway genes (NLRP3, caspase 1, IL-1β, and IL-18) to study the drug effects on inflammation [45] (Table 2).…”

Section: In-vivomentioning

confidence: 99%

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Efficacy of non-surgical interventions for promoting improved functional outcomes following acute compartment syndrome: A systematic review

et al. 2022

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Background Acute compartment syndrome (ACS) is a devastating complication which develops following a traumatic extremity injury that results in increased pressure within osteofascial compartments, thereby leading to ischemia, muscle and nerve necrosis, and creates a life-threatening condition if left untreated. Fasciotomy is the only available standard surgical intervention for ACS. Following fasciotomy the affected extremity is plagued by prolonged impairments in function. As such, an unmet clinical need exists for adjunct, non-surgical therapies which can facilitate accelerated functional recovery following ACS. Thus, the purpose of this systematic review was to examine the state of the literature for non-surgical interventions that aim to improve muscle contractile functional recovery of the affected limb following ACS. Methods English language manuscripts which evaluated non-surgical interventions for ACS, namely those which evaluated the function of the affected extremity, were identified as per PRISMA protocols via searches within three databases from inception to February 2022. Qualitative narrative data synthesis was performed including: study characteristics, type of interventions, quality, and outcomes. Risk of bias (RoB) was assessed using the Systematic Review Centre for Laboratory Animal Experimentation’s (SYRCLE) RoB tool and reported level of evidence for each article. Results Upon review of all initially identified reports, 29 studies were found to be eligible and included. 23 distinct non-surgical interventions were found to facilitate improved muscle contractile function following ACS. Out of 29 studies, 15 studies which evaluated chemical and biological interventions, showed large effect sizes for muscle function improvement. Conclusions This systematic review demonstrated that the majority of identified non-surgical interventions facilitated an improvement in muscle contractile function following pathological conditions of ACS.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: In-vivomentioning

confidence: 99%

Section: In-vivomentioning

confidence: 99%

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Efficacy of non-surgical interventions for promoting improved functional outcomes following acute compartment syndrome: A systematic review

et al. 2022

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Exploring Cinnamaldehyde: Preparation Methods, Biological Functions, Efficient Applications, and Safety

Wang,

Zhao,

Huang

et al. 2024

Food Reviews International

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Contusion concomitant with ischemia injury aggravates skeletal muscle necrosis and hinders muscle functional recovery

Deng

Qiu

Liao

et al. 2022

Exp Biol Med (Maywood)

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Contusion concomitant with ischemia injury to skeletal muscles is common in civilian and battlefield trauma. Despite their clinical importance, few experimental studies on these injuries are reported. The present study established a rat skeletal muscle contusion concomitant with ischemia injury model to identify skeletal muscle alterations compared with contusion injury or ischemia injury. Macroscopic and microscopic morphological evaluation showed that contusion concomitant with ischemia injury aggravated muscle edema and hematoxylin–eosin (HE) injury score at 24 h postinjury. Serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels, together with gastrocnemius muscle (GM) tumor necrosis factor-alpha (TNF-α) content elevated at 24 h postinjury too. During the 28-day follow-up, electrophysiological and contractile impairment was more severe in the contusion concomitant with ischemia injury group. In addition, contusion concomitant with ischemia injury decreased the percentage of larger (600–3000 μm2) fibers and increased the fibrotic area and collagen I proportion in the GM. Smaller proportions of Pax7+ and MyoD+ satellite cells (SCs) were observed in the contusion concomitant with ischemia injury group at 7 days postinjury. In conclusion, contusion concomitant with ischemia injury to skeletal muscle not only aggravates early muscle fiber necrosis but also hinders muscle functional recovery by impairing SC differentiation and exacerbating fibrosis during skeletal muscle repair.

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Effects of Trans-Cinnamaldehyde on Reperfused Ischemic Skeletal Muscle and the Relationship to Laminin

Cited by 3 publications

References 37 publications

Efficacy of non-surgical interventions for promoting improved functional outcomes following acute compartment syndrome: A systematic review

Efficacy of non-surgical interventions for promoting improved functional outcomes following acute compartment syndrome: A systematic review

Exploring Cinnamaldehyde: Preparation Methods, Biological Functions, Efficient Applications, and Safety

Contusion concomitant with ischemia injury aggravates skeletal muscle necrosis and hinders muscle functional recovery

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