Effects of Transcranial Direct Current Stimulation on Potential P300-Related Events and Alpha and Beta EEG Band Rhythms in Parkinson's Disease

Fabio, Rosa Angela; Suriano, Rossella; Gangemi, Antonio

doi:10.31083/j.jin2302025

Cited by 5 publications

(1 citation statement)

References 111 publications

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“…It is considered a safe rehabilitative strategy, with a low incidence of side effects and characterized by painless application and cost-effectiveness [ 34 , 35 ]. tDCS has achieved notable success and promising results in treating degenerative brain processes, including those related to physiological aging and pathological conditions [ 36 , 37 , 38 , 39 ]. Furthermore, the application of tDCS has shown promise in managing mild cognitive decline and dementia [ 40 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Does Transcranial Direct Current Stimulation Affect Potential P300-Related Events in Vascular Dementia? Considerations from a Pilot Study

Gangemi,

Fabio,

Suriano

et al. 2024

Biomedicines

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Vascular dementia, the second most common type of dementia, currently lacks a definitive cure. In the pursuit of therapies aimed at slowing its progression and alleviating symptoms, transcranial direct current stimulation (tDCS) emerges as a promising approach, characterized by its non-invasive nature and the ability to promote brain plasticity. In this study, the primary objective was to investigate the effects of a two-week cycle of tDCS on the dorsolateral prefrontal cortex (DLPFC) and neurophysiological functioning in thirty patients diagnosed with vascular dementia. Each participant was assigned to one of two groups: the experimental group, which received anodal tDCS to stimulate DPCFL, and the control group, which received sham tDCS. Neurophysiological functions were assessed before and after tDCS using P300 event-related potentials (ERPs), while neuropsychological function was evaluated through a Mini-Mental State Examination (MMSE). The results showed a reduction in P300 latency, indicating a faster cognitive process; an increase in P300 amplitude, suggesting a stronger neural response to cognitive stimuli; and a significant improvement in MMSE scores compared to the control group, indicating an overall enhancement in cognitive functions. These findings suggest that tDCS could represent a promising therapeutic option for improving both neurophysiological and cognitive aspects in patients with vascular dementia.

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Section: Introductionmentioning

confidence: 99%

Does Transcranial Direct Current Stimulation Affect Potential P300-Related Events in Vascular Dementia? Considerations from a Pilot Study

Gangemi,

Fabio,

Suriano

et al. 2024

Biomedicines

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Aperiodic spectral slope tracks the effects of brain state on saliency responses in the human auditory cortex

Mocchi,

Bartoli,

Magnotti

et al. 2024

Sci Rep

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Pupil-linked arousal reflects intracranial aperiodic neural activity in the human auditory cortex

Mocchi,

Bartoli,

Magnotti

et al. 2024

Preprint

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Disrupted cortical and peripheral neural responses to salient stimuli occur in neural disease states, which may be rooted in pathophysiological neuromodulatory system dynamics. Although low-frequency oscillatory activity is the canonical measure of cortical neuromodulatory state, aperiodic 1/f slope encapsulates the balance between low-frequency and high-frequency activity and could thus provide a more sensitive electrophysiological measure. Here, we simultaneously record pupil diameter as a noninvasive measure of brain state, and intracranial local field potentials (LFP) in the auditory cortex and association regions in humans during an auditory oddball task. We demonstrate a trial-by-trial relationship between pupil and auditory cortical responses that is specific to the high gamma frequency band. We find that pupillary and cortical responses show a state-dependent relationship with aperiodic 1/f slope that is similar to canonical low-frequency measures, but that only the 1/f measure shows a trial-by-trial relationship with tonic and phasic pupil activity. Finally, salient stimuli trigger prolonged shifts in aperiodic 1/f activity after stimulus playback, which associates with altered responses on subsequent trials. Taken together, aperiodic slope captures tonic and phasic components of cortical state at the single trial level, providing mechanistic insight into human saliency responses and a path for pupillometry as a non-invasive readout.

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Effects of Transcranial Direct Current Stimulation on Potential P300-Related Events and Alpha and Beta EEG Band Rhythms in Parkinson's Disease

Cited by 5 publications

References 111 publications

Does Transcranial Direct Current Stimulation Affect Potential P300-Related Events in Vascular Dementia? Considerations from a Pilot Study

Does Transcranial Direct Current Stimulation Affect Potential P300-Related Events in Vascular Dementia? Considerations from a Pilot Study

Aperiodic spectral slope tracks the effects of brain state on saliency responses in the human auditory cortex

Pupil-linked arousal reflects intracranial aperiodic neural activity in the human auditory cortex

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