Effects of transcranial direct current stimulation during sleep on memory performance in patients with schizophrenia

Göder, Robert; Baier, Paul Christian; Beith, Bente; Baecker, Cora; Seeck‐Hirschner, Mareen; Junghanns, Klaus; Marshall, Lisa

doi:10.1016/j.schres.2012.12.014

Cited by 95 publications

(59 citation statements)

References 8 publications

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“…did not significantly alter sleep but improved word list recall 72 . In a small preliminary study, eszopiclone, which acts on γ-aminobutyric acid (GABA)-ergic neurons in the TRN 73 , significantly increased spindles in schizophrenia but not sleep-dependent memory 30 .…”

Section: Discussionmentioning

confidence: 80%

Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia

Demanuele

Bartsch

Baran

et al. 2016

Sleep

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Demanuele et al., 2016 1 This study is not a clinical trial. Demanuele et al., 2016 3 Coordination of Slow Waves with Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia AbstractStudy Objectives: Schizophrenia patients have correlated deficits in sleep spindle density and sleep-dependent memory consolidation. In addition to spindle density, memory consolidation is thought to rely on the precise temporal coordination of spindles with slow waves (SWs). We investigated whether this coordination is intact in schizophrenia and its relation to motor procedural memory consolidation.Methods: Twenty-one chronic medicated schizophrenia patients and 17 demographicallymatched healthy controls underwent two nights of polysomnography with training on the finger tapping motor sequence task (MST) on the second night and testing the following morning. We detected SWs (0.5-4Hz) and spindles during non-rapid eye-movement (NREM) sleep. We measured SW-spindle phase-amplitude coupling and its relation with overnight improvement of MST performance.Results: Patients did not differ from controls in the timing of SW-spindle coupling. In both groups spindles peaked during the SW upstate. For patients only, the later in the SW upstate that spindles peaked and the more reliable this phase relationship, the greater the overnight MST improvement.Regression models that included both spindle density and SW-spindle coordination predicted overnight improvement significantly better than either parameter alone suggesting that both contribute to memory consolidation.Conclusions: Schizophrenia patients show intact spindle-SW temporal coordination and these timing relationships, together with spindle density, predict sleep-dependent memory consolidation.These relations were seen only in patients suggesting that their memory is more dependent on optimal spindle-SW timing, possibly due to reduced spindle density. Interventions to improve memory may need to both increase spindle density and optimize the coordination of NREM oscillations.

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Section: Discussionmentioning

confidence: 80%

Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia

Demanuele

Bartsch

Baran

et al. 2016

Sleep

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“…58 Another single-session experiment applied tDCS oscillating at the frequency of the sleep slow oscillation to the left and right DLPFC in 14 schizophrenia patients during sleep and showed a greater verbal retention capacity following active tDCS compared to sham tDCS. 59 Concerning working memory, one single active tDCS session (20 min, 2 mA, anode left DLPFC [F3], cathode right supraorbital) was more effective in improving n-back performance (d-prime) compared to sham tDCS and to 1 mA stimulation after 20 and 40 minutes, but not immediately after stimulation. 60 Another experimental study showed that active 20 Hz rTMS reduced frontal gamma oscillatory activity elicited during working memory performance (n-back) in 24 schizophrenia patients but enhanced activity in healthy controls.…”

Section: Results Of Individual Studies (Outcomes)mentioning

confidence: 99%

Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Hasan

Strube

Palm

et al. 2016

SCHBUL

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Despite many years of research, there is still an urgent need for new therapeutic options for the treatment of cognitive deficits in schizophrenia. Noninvasive brain stimulation (NIBS) has been proposed to be such a novel add-on treatment option. The main objective of this review was to systematically evaluate the cognitive effects of repetitive NIBS in schizophrenia. As most studies have not been specifically designed to investigate cognition as primary outcome, we have focused on both, primary and secondary outcomes. The PubMed/MEDLINE database (1985-2015) was systematically searched for interventional studies investigating the effects of repetitive NIBS on schizophrenia symptoms. All interventional clinical trials using repetitive transcranial stimulation, transcranial theta burst stimulation, and transcranial direct current stimulation for the treatment of schizophrenia were extracted and analyzed with regard to cognitive measures as primary or secondary outcomes. Seventy-six full-text articles were assessed for eligibility of which 33 studies were included in the qualitative synthesis. Of these 33 studies, only 4 studies included cognition as primary outcome, whereas 29 studies included cognitive measures as secondary outcomes. A beneficial effect of frontal NIBS could not be clearly established. No evidence for a cognitive disruptive effect of NIBS (temporal lobe) in schizophrenia could be detected. Finally, a large heterogeneity between studies in terms of inclusion criteria, stimulation parameters, applied cognitive measures, and follow-up intervals was observed. This review provides the first systematic overview regarding cognitive effects of repetitive NIBS in schizophrenia.

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“…While healthy adults [32,33], adults suffering from schizophrenia [56], and children with ADHD benefited from toDCS during sleep, elderly healthy participants did not [57]. Of course, slight differences in stimulation protocol between the studies should be taken into account.…”

Section: Discussionmentioning

confidence: 99%

Transcranial Oscillatory Direct Current Stimulation During Sleep Improves Declarative Memory Consolidation in Children With Attention-deficit/hyperactivity Disorder to a Level Comparable to Healthy Controls

et al. 2014

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Effects of transcranial direct current stimulation during sleep on memory performance in patients with schizophrenia

Cited by 95 publications

References 8 publications

Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia

Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia

Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Transcranial Oscillatory Direct Current Stimulation During Sleep Improves Declarative Memory Consolidation in Children With Attention-deficit/hyperactivity Disorder to a Level Comparable to Healthy Controls

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