Effects of transcranial direct current stimulation coupled with repetitive electrical stimulation on cortical spreading depression

Fregni, Felipe; Liebetanz, David; Monte-Silva, Kátia; Oliveira, Manuella B.; Amâncio-dos-Santos, Ângela; Nitsche, Michael A.; Pascual‐Leone, Álvaro; Guedes, Rubem Carlos Araújo

doi:10.1016/j.expneurol.2006.09.019

Cited by 69 publications

(68 citation statements)

References 15 publications

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“…However, recent reports have documented experimental evidence of CSD-effects produced by central (cortical) electrical stimulation (Fregni et al 2007) and transcranial direct current stimulation (Liebetanz et al 2006). These new therapy forms are considered potentially promising in the treatment of important human pathologies, like Parkinson's disease, depression, migraine and stroke (Benabid 2003;Hummel et al 2005;Siniatchkin et al 2007).…”

Section: Introductionmentioning

confidence: 97%

Nutrition-dependent influence of peripheral electrical stimulation during brain development on cortical spreading depression in weaned rats

Monte-Silva

Assis

Leal

et al. 2007

Nutritional Neuroscience

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As several other factors, nutritional deficiency and sensory input hyperactivation can influence the mammalian brain development. This work investigated the effects of repeated episodes of early peripheral electrostimulation (PE), associated or not with early malnutrition, on cortical spreading depression (CSD) propagation. From postnatal days 7-28, well-nourished and malnourished Wistar rat pups (whose mothers were fed a 23 and 8% protein diet, respectively) received daily sessions of repetitive PE (2 or 60 Hz-square-wave pulses, 1.5 ms duration, 10-40 V intensity), delivered by two electrodes attached to the left paws. At postnatal days 35-45, under anesthesia, KCl-elicited spreading depression was monitored at two cortical points of both hemispheres. In the well-nourished rats, 2 Hz, but not 60 Hz PE was associated with slower spreading depression propagation in the hemisphere contralateral to the stimulated body-side, as compared to the ipsilateral hemisphere. In the malnourished rats, this effect was found for both 2 and 60 Hz stimulation frequencies. In the sham-stimulated controls, which received similar paw-electrodes, but were not stimulated, no inter-hemispheric spreading depression differences were seen. The results indicate an impairing effect of early PE on spreading depression propagation, which is frequency-dependent and can be influenced by the animal's nutritional status. Data raise the question whether brain plasticity changes consequent to the interaction between sensory input activation and malnutrition would be involved in the here described spreading depression effects.

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Section: Introductionmentioning

confidence: 97%

Nutrition-dependent influence of peripheral electrical stimulation during brain development on cortical spreading depression in weaned rats

Monte-Silva

Assis

Leal

et al. 2007

Nutritional Neuroscience

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“…Increased excitability has also been associated with increased CSD speed (Liebetanz et al, 2006). The possibility of neurostimulation to modulate neuro-excitability in migraine is also supported by some experimental evidence using TMS and TCS (Brighina et al, 2002;Fregni et al, 2007). However, the link between the change in cortical excitability and the CSD or the migraine attack is experimentally shown to be nontrivial (Rocha et al, 2015) and demands computational investigation.…”

Section: Cortical Spreading Depressionmentioning

confidence: 93%

Computational modeling of neurostimulation in brain diseases

Wang

Hutchings

Kaiser

2015

Progress in Brain Research

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“…A potentiation effect of brain evoked field potentials (Guedes, Tsurudome, & Matsumoto, 2005), as well as an LTP-enhancement (Gorji & Speckmann, 2004), have been demonstrated after induction of CSD, suggesting a CSD-associated facilitation of synaptic transmission. Since it is known that CSD elicitation and propagation depends on the level of excitability in the cerebral cortex (Pinto & Guedes, 2008), and that several excitabilitychanging environmental, pharmacological, and nutritional manipulations also modify CSD susceptibility (Amâncio-dos- Costa-Cruz, Amâncio-dos-Santos, & Guedes, 2006;De Luca, Cioffi, & Bures, 1977;Fregni et al, 2007;Guedes, 2005;), it is reasonable to predict that both treatments used in the present study -tryptophan injection and sleep deprivation -could influence CSD propagation features.…”

Section: Discussionmentioning

confidence: 99%

Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats.

Filho

Vasconcelos

Guedes

2009

Psychology & Neuroscience

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The enhanced availability of tryptophan in the brain, as a consequence of exogenous tryptophan administration, can increase neuronal serotonin synthesis and this can interfere with brain function. REM sleep deprivation (D) constitutes another external factor that can change brain excitability, facilitating, in some cases, the manifestation of neurological diseases like epilepsy. Here we used cortical spreading depression (CSD) as a neurophysiological parameter to investigate the effects of a single L-tryptophan intraperitoneal injection combined or not with 72h D-condition (water-tank technique) in rats. A 1h baseline CSD-recording was performed under urethane+chloralose (1g/kg + 40mg/kg) anesthesia and revealed increased CSD propagation velocities in D rats, as compared with non-deprived (ND), or pseudo-deprived (Pseudo) controls. After the baseline CSD recording, L-tryptophan was immediately injected (125 mg/kg ip, dissolved in water at pH about 3) and this was followed by a significant decrease of CSD propagation velocities, as compared to the baseline values in the same animals of the Pseudo, ND and D condition. In an additional control group (ND rats injected with the vehicle), no CSD propagation change was seen. Our findings indicate an important acute antagonistic influence of tryptophan on CSD propagation, which is not affected by REM sleep deprivation. We suggest that this tryptophan effect may be due to a serotonin-mediated action, probably caused by increased serotonin synthesis as a consequence of enhanced tryptophan availability in the brain.

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Effects of transcranial direct current stimulation coupled with repetitive electrical stimulation on cortical spreading depression

Cited by 69 publications

References 15 publications

Nutrition-dependent influence of peripheral electrical stimulation during brain development on cortical spreading depression in weaned rats

Nutrition-dependent influence of peripheral electrical stimulation during brain development on cortical spreading depression in weaned rats

Computational modeling of neurostimulation in brain diseases

Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats.

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