Effects of transcranial direct current stimulation on temperature and pain perception

Mordillo-Mateos, Laura; Dileone, M.; Soto-León, Vanesa; Brocalero-Camacho, Angela; Pérez-Borrego, Yolanda A.; Onate-Figuérez, Ana; Aguilar, Juan; Oliviero, Antonio

doi:10.1038/s41598-017-03173-2

Cited by 18 publications

(16 citation statements)

References 37 publications

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“…Regarding the qualitative analysis of included studies a "strong" level of evidence was found for reduction of pain intensity with tDCS 34, 39-42 , a "limited" level of evidence in suboccipital (cerebellar) DCS 43 , and a "conflicting" level in spinal-DCS studies 44,45 . For heat and cold pain thresholds, a "strong" level of evidence was found for increase of thermal thresholds in tDCS studies 10,34,38,[46][47][48][49][50][51][52] . For pressure pain thresholds, a "conflicting" level of evidence was found for the increase of mechanical pain thresholds in tDCS studies 35,38,46,53,54 .…”

Section: Qualitative Analysismentioning

confidence: 97%

“…Of the 31 studies included, 12 were selected for quantitative analysis of heat and cold pain thresholds following active tDCS, with six studies showing a significant increase in heat pain threshold in active tDCS groups in front of sham tDCS groups 34,38,46,47,49,51 , and two studies failing to demonstrate a significant difference between active and sham tDCS 48,53 . For cold pain threshold, seven studies found a significant increase in threshold following active tDCS compared to sham tDCS 8,10,38,46,47,50,52 , and only one study failed to show a significant difference between active and sham tDCS 48 . The majority of published studies support DCS modulation of thermal detection or pain thresholds 34,46,47,50 or tolerance in healthy participants 8, 51, 52 .…”

Section: The Effects Of Dcs On Heat and Cold Pain Thresholdsmentioning

confidence: 99%

“…For cold pain threshold, seven studies found a significant increase in threshold following active tDCS compared to sham tDCS 8,10,38,46,47,50,52 , and only one study failed to show a significant difference between active and sham tDCS 48 . The majority of published studies support DCS modulation of thermal detection or pain thresholds 34,46,47,50 or tolerance in healthy participants 8, 51, 52 . The results obtained in this study are supported by a recent systematic review that found an improvement in thermal pain thresholds 17 .…”

Section: The Effects Of Dcs On Heat and Cold Pain Thresholdsmentioning

confidence: 99%

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Efficacy of Direct Current Stimulation on Experimental Sensory Modalities and Pain Outcome Measures in Healthy Participants: Systematic Review and Meta-Analysis.

García-Barajas¹,

Taylor²,

Romero³

et al. 2020

Preprint

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Background: Objectives. The objective of this study was to compare the efficacy of direct current stimulation (DCS) applied at the transcranial, suboccipital and spinal level on experimental sensory modalities and pain outcome measures in healthy subjects. The hypothesis of this study was that systematic analysis of the efficacy of DCS on modulating evoked thermal and mechanical pain modalities and mechanisms such as endogenous pain modulation in healthy individuals would reveal sensitive outcome measures help develop this technique for the control of chronic pain. Materials and Methods. Database searches were conducted up to December 2019 for randomized controlled trials that performed sham-controlled DCS of experimental sensory modalities and pain outcomes following transcranial, suboccipital and spinal locations in healthy participants. Standardized mean differences with 95% confidence intervals were calculated for sensory modalities, including random-effect metanalysis. Results: Thirty-one studies were included for analysis (647 participants). A significant decrease in pain intensity for active vs sham transcranial stimulation was identified for pain intensity (n=158; SMD=0.79; 95% CI=0.56 to 1.02), a significant increase in heat pain threshold (n=222; SMD=1.16; 95% CI=0.95 to 1.37), and a significant increase in cold pain threshold (n = 155; SMD = 0.77, 95% CI 0.53 to 1.01). No significant modulation of pressure pain threshold was identified with DCS and only a limited number of studies focused on experimental pain modulation following neuromodulation at the suboccipital or spinal level. Conclusions: These results show significant transcranial DCS neuromodulation of pain intensity and on thermal pain modalities. Future studies should focus on endogenous pain and sensory modality modulation with sham-controlled DCS applied at transcranial, suboccipital and spinal locations.

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Section: Qualitative Analysismentioning

confidence: 97%

Section: The Effects Of Dcs On Heat and Cold Pain Thresholdsmentioning

confidence: 99%

Section: The Effects Of Dcs On Heat and Cold Pain Thresholdsmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Direct Current Stimulation on Experimental Sensory Modalities and Pain Outcome Measures in Healthy Participants: Systematic Review and Meta-Analysis.

García-Barajas¹,

Taylor²,

Romero³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Examples of devices developed based on TENS concepts include NEMOS (Cerbomed GmbH, Erlanger, Germany), a portable device that targets the auricular branch of the vagus nerve via electrodes placed on the concha of the outer ear, Cefaly (CEFALY-Technology, Seraing, Belgium), a wearable device for supraorbital stimulation by a bipolar electrode patch on the forehead and gammaCore (electroCore LLC, NJ, USA), a handheld noninvasive vagal nerve stimulator, all for the treatment and management of migraine. Spinal cord stimulation using implanted electrodes [12], occipital nerve stimulation using implantable electrodes [13], transcranial magnetic stimulation [14] and transcranial direct current stimulation [15] have also been used to treat various neuropathic pain patients.…”

Section: Example Applications Of Neuromodulationmentioning

confidence: 99%

Wearable Neuromodulators

Shiraz¹,

Leaker²,

Demosthenous³

2018

Wearable Technologies

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In neuromodulation, by delivering a form of stimulus to neural tissue the response of an associated neural circuit may be changed, enhanced or inhibited (i.e., modulated) as desired. This powerful technique may be used to treat various medical conditions as outlined in this chapter. After a brief introduction to the human nervous system, key example applications of electrical neuromodulation such as cardiac pacemakers, devices for pain relief, deep brain stimulation, cochlear implant and visual prosthesis and their respective methods of deployment are discussed. Furthermore, key features of wearable neuromodulators with reference to some existing devices are briefly reviewed. This chapter is concluded by a case study on design and development of a wearable device with non-invasive electrodes for treating lower urinary tract dysfunctions after spinal cord injury.

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“…Given very little has been assessed regarding the effects of tDCS on the pressure pain threshold (PPT) in healthy participants, PPT is an interesting focus of study to enhance our understanding of tDCS effects 12 , 13 . tDCS application to the M1 and any resulting changes in sensitivity have not yet been investigated and could provide interesting results.…”

Section: Introductionmentioning

confidence: 99%

Transcranial direct-current stimulation (tDCS) in the primary motor cortex and its effects on sensorimotor function: a quasi-experimental single-blind sham-controlled trial

Lerma-Lara

Montbron

Guérin

et al. 2021

Sci Rep

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The main aim was to assess the short-term effects of active-tDCS (a-tDCS) in the primary motor cortex (anodal stimulation-M1) on sensorimotor variables. These variables included discriminative sensation through the two-point discrimination (2-PD) test, tactile acuity threshold and pressure pain threshold (PPT), and electromyographic (EMG) activity compared with a sham-tDCS (s-tDCS) in healthy individuals. A total of 100 participants were included. Fifty of the participants received the a-tDCS application of 2 mA for 20 min, whereas the remaining fifty received the s-tDCS. The 2-PD and tactile acuity threshold in thenar eminence of the hand and in the dorsal part of the foot and also, PPT and EMG activity during maximal voluntary contraction in the biceps brachii and rectus femoris were assessed before and after the tDCS application. The a-tDCS intervention was not significantly superior to the s-tDCS in any variable. However, significant within-group pre- and post-intervention differences were found in the a-tDCS, such as the tactile acuity threshold in thenar eminence of the hand, with a small effect size (p = .012, d = 0.20) and in the PPT of the rectus femoris, also with a small effect size (p = .001, d = − 0.17). Regarding EMG activity, a trend towards greater activity was observed in participants with a-tDCS compared with s-tDCS, which showed a trend towards decreased EMG activity. In fact, although no differences were found between the groups, within-group differences were statistically significant in the biceps brachii pre- and postintervention (p = .023, d = − 0.16, and p = .002, d = 0.18, respectively), and also in the rectus femoris, only in the a-tDCS, with a small effect size (p = .011, d = − 0.14). This study showed no significant between-group differences in sensorimotor outcomes. A single session of tDCS in isolation appears to produce immediate effects in healthy participants on sensorimotor function; however, these effects were very small.

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Effects of transcranial direct current stimulation on temperature and pain perception

Cited by 18 publications

References 37 publications

Efficacy of Direct Current Stimulation on Experimental Sensory Modalities and Pain Outcome Measures in Healthy Participants: Systematic Review and Meta-Analysis.

Efficacy of Direct Current Stimulation on Experimental Sensory Modalities and Pain Outcome Measures in Healthy Participants: Systematic Review and Meta-Analysis.

Wearable Neuromodulators

Transcranial direct-current stimulation (tDCS) in the primary motor cortex and its effects on sensorimotor function: a quasi-experimental single-blind sham-controlled trial

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