Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer

Wu, Huaming; Wang, Kun; Li, Guixian; Meng, Dexin; Han, Jiacheng; Wang, Guonian; Li, Y U

doi:10.3892/etm.2015.2913

Cited by 19 publications

(14 citation statements)

References 27 publications

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“…Studies demonstrated that acupuncture promoted the release of cytokines activated by NK cells and enhanced nonspecific antitumor immunity. 10 Additionally, a current study by Wu et al suggested that TAES was able to partially attenuate the postoperative immune depression of patients with lung cancer by regulating the balance of T lymphocytes and the expression levels of related cytokines and transcription factors, 15 but they did not discuss the impact of TEAS on NK cells and related immunologic factors, such as TNF-α and IL-6. Actually, NK cells play an all-star role in protecting hosts from carcinogenesis and metastases.…”

Section: Discussionmentioning

confidence: 94%

“… 14 Therefore, NK cells, TNF-α, and IL-6 were selected as the immunological factors of interest. The TEAS has been proven to provide perioperative immune system protection by regulating the balance of T lymphocytes and the expression levels of related cytokines and transcription factors, 15 and the procedure may be a promising strategy for treating postoperative immunological dysfunction in patients with NSCLC. However, relevant studies regarding these effects are relatively lacking.…”

Section: Introductionmentioning

confidence: 99%

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Transcutaneous Electrical Acupoint Stimulation Improves Immunological Function During the Perioperative Period in Patients With Non-Small Cell Lung Cancer Undergoing Video-Assisted Thoracic Surgical Lobectomy

Zhou

Gan

et al. 2018

Technol Cancer Res Treat

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The immunological function of patients with malignant tumors may be suppressed during the perioperative period. However, details on the effects of transcutaneous electrical acupoint stimulation (TEAS) on immunological function are relatively lacking. We designed this study to examine the effects of TEAS on the immunological function of patients with non-small cell lung cancer (NSCLC) during the perioperative period. Participants (n = 144) were enrolled and randomly assigned into group TEAS or group sham TEAS. TEAS on bilateral Feishu (BL13), Hegu (L14), and Zusanli (ST36) was performed continuously throughout the procedure. The primary outcome was the quantities of natural killer (NK) cells at 30 minutes before induction (T0), 5 minutes after intubation (T1), at the beginning of the operation (T2), at the beginning of the lobectomy (T3), at the beginning of the lymphadenectomy (T4), and immediately after extubation (T5). The secondary outcomes were the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) at T0 to T5, the mean arterial pressure (MAP) and heart rate (HR), the intraoperative consumption of propofol and remifentanil, the incidence of hypoxemia, postoperative nausea and vomiting (PONV), and the length of hospital stay. The quantities of NK cells were decreased in group sham TEAS after intubation compared to that in group TEAS, while the quantities of NK cells in group TEAS were similar at T0 to T5. Meanwhile, the quantities of NK cells in group sham TEAS at T1 (P = .012), T2 (P < .001), T3 (P = .027), T4 (P = .045), and T5 (P = .021) were lower than those in group TEAS. In group TEAS, the serum levels of TNF-α were lower at T1 to T5, while the levels of IL-6 were lower at T2 to T5. Furthermore, the intraoperative MAP and HR were more stable, the total propofol and remifentanil consumptions were lower, and the length of hospital stay was shorter than those in group sham TEAS. The application of TEAS can effectively reverse the decrease in NK cells, decrease the serum levels of TNF-α and IL-6, maintain hemodynamic stability during the perioperative period, decrease the consumption of propofol and remifentanil, and shorten the length of the hospital stay.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Transcutaneous Electrical Acupoint Stimulation Improves Immunological Function During the Perioperative Period in Patients With Non-Small Cell Lung Cancer Undergoing Video-Assisted Thoracic Surgical Lobectomy

Zhou

Gan

et al. 2018

Technol Cancer Res Treat

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“…After the return of spontaneous circulation (ROSC), CA patients with systemic ischemia/reperfusion injury (IRI) can manifest 'sepsis-like' syndromes and immune disorders which can lead to infections (3)(4)(5). CD4 + T lymphocytes are effector cells in the adaptive immune system of humans and play important roles in ghting infections and the pathogenesis of IRI (6,7). Upon activation of the T cell receptor (TCR), naïve CD4 + T lymphocytes differentiate into T-helper 1 (Th1), and Th2 subsets (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of programmed cell death-1 on circulatory Th1 and Th2 cells in cardiac arrest patients in the early period after the return of spontaneous circulation

Xie

et al. 2020

Preprint

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Background: In patients with immune disorders, the role of T-helper (Th) cells immediately following the return of spontaneous circulation (ROSC) after cardiac arrest is unclear. We evaluated the influence of plasma cytokine and programmed cell death-1 (PD-1) expression on circulating Th1 and Th2 cells and elucidated their role in immune function immediately following ROSC. Methods: We enrolled 92 non-consecutive cardiac arrest patients that experienced ROSC between 6 and 24 h post-cardiac arrest as well as 40 healthy controls. Outcome data were collected 28 days after ROSC. Peripheral blood samples were analyzed to determine Th1 and Th2 cell counts and PD-1 expression. The plasma levels of cytokines, including interferon-γ, tumor necrosis factor-α, interleukin (IL)-4, IL-6, and IL-10 were determined. Results: Compared with those in healthy individuals, Th1 and Th2 cell counts and Th1/Th2 cell ratios in CA patients after ROSC were significantly reduced (P < 0.05). The percentages of PD-1 expression were significantly higher in Th1 and Th2 cells (P < 0.01). There were no significant differences in Th1 and Th2 cell expression of PD-1 between survivors and non-survivors. Plasma levels of IL-6 and IL-10 in ROSC patients were significantly higher during the early period (P < 0.05). Conclusions: Th1 and Th2 cell expression of PD-1 is upregulated in the period immediately following ROSC in cardiac arrest patients and may be responsible for the observed immunosuppression in these patients during this period.

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“…In an attempt to understand the mechanisms of pain and the possible effectiveness of TENS in enabling increasingly effective treatments, recent studies have noted that in addition to analgesia, TENS may have an effect on the circulatory [ 7 , 8 ], healing [ 9 , 10 ], and inflammatory systems [ 6 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis

Almeida

Figueiredo

Filho³

et al. 2018

Mediators of Inflammation

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The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in six databases to identify randomized controlled trials with the criteria: humans older than 18 years (adults), use of TENS in the experimental group, and having at least one pre- and postintervention blood level of at least one proinflammatory cytokine. The risk of bias and the level of evidence were assessed. Five studies were included involving 240 participants. The heterogeneity of the studies was high (I 2: 85%); therefore, we used a random-effects meta-analysis. It was observed through the meta-analysis synthesis measures that there were statistically significant differences following the use of TENS to reduce the general group of cytokines. When grouped by chronic disease, by postoperative settings, or by individual studies in the case of IL-6, it was observed that the significant reduction of cytokines related to the use of TENS was maintained. The use of TENS reduced the blood levels of proinflammatory cytokines (we observed a protective factor of TENS in relation to inflammation). The protocol of the systematic review was registered in PROSPERO, CRD42017060379.

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Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer

Cited by 19 publications

References 27 publications

Transcutaneous Electrical Acupoint Stimulation Improves Immunological Function During the Perioperative Period in Patients With Non-Small Cell Lung Cancer Undergoing Video-Assisted Thoracic Surgical Lobectomy

Transcutaneous Electrical Acupoint Stimulation Improves Immunological Function During the Perioperative Period in Patients With Non-Small Cell Lung Cancer Undergoing Video-Assisted Thoracic Surgical Lobectomy

Overexpression of programmed cell death-1 on circulatory Th1 and Th2 cells in cardiac arrest patients in the early period after the return of spontaneous circulation

Effects of Transcutaneous Electrical Nerve Stimulation on Proinflammatory Cytokines: Systematic Review and Meta-Analysis

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