Effects of transcutaneous auricular vagus nerve stimulation on P300 magnitudes and salivary alpha-amylase during an auditory oddball task

D’Agostini, Martina; Burger, Alan E.; Jelinčić, Valentina; Leupoldt, Andreas von; Diest, Ilse Van

doi:10.1016/j.biopsycho.2023.108646

Biological Psychology

2023

DOI: 10.1016/j.biopsycho.2023.108646

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Effects of transcutaneous auricular vagus nerve stimulation on P300 magnitudes and salivary alpha-amylase during an auditory oddball task

Martina D’Agostini

Alan E. Burger

Valentina Jelinčić

et al.

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Cited by 4 publications

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Processing of acoustic and phonological information of lexical tones at pre-attentive and attentive stages

Rong,

Weng,

Peng

2023

Language, Cognition and Neuroscience

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Processing of acoustic and phonological information of lexical tones at pre-attentive and attentive stagesWhile Mismatch Negativity (MMN) and P300 have been found to correlate with the processing of acoustic and phonological information involved in speech perception, there is controversy surrounding how these two components index acoustic and/or phonological processing at pre-attentive and attentive stages. The current study employed both passive and active oddball paradigms to examine neural responses to lexical tones at the two stages in Cantonese speakers, using the paradigm of categorical perception (CP) where the between-and withincategory deviants share the same acoustic distance from the standard but differ in the involvement of phonological information. We failed to observe a CP effect in P300, which might indicate that this component doesn't necessarily index phonological processing, while MMN does, as reflected by the finding of a greater MMN amplitude elicited from the between-category than within-category deviant. Nevertheless, phonological processing might be overridden by acoustic processing among participants who are sensitive to pitch.

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Processing of acoustic and phonological information of lexical tones at pre-attentive and attentive stages

Rong,

Weng,

Peng

2023

Language, Cognition and Neuroscience

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State dependent vagus nerve stimulation for targeted plasticity therapy: challenges and considerations

Nandakumar,

Mylavarapu,

Harris

et al. 2024

Front. Control Eng.

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Targeted plasticity therapy (TPT) utilizes vagus nerve stimulation (VNS) to promote improvements in function following neurological injury and disease. During TPT, a brief burst of VNS induces neuromodulator release, which when paired with relevant behavioral events can influence functionally relevant neuroplasticity. Functional improvements following TPT are therefore in part mediated by neuromodulator signaling. Unfortunately, comorbidities associated with neurological disease often result in altered cognitive states that can influence neuromodulator signaling, potentially impeding neuroplasticity induced by TPT. Aside from altered cognitive states, cardiorespiratory rhythms also affect neuromodulator signaling, due to the vagus nerve’s role in relaying visceral sensory information from the cardiovascular and respiratory systems. Moreover, precise VNS delivery during specific periods of the cardiorespiratory rhythms may further improve TPT. Ultimately, understanding the impact of patient-specific states on neuromodulator signaling may likely facilitate optimized VNS delivery, paving the way for personalized neuromodulation during TPT. Overall, this review explores challenges and considerations for developing advanced TPT paradigms, focusing on altered cognitive states and cardiorespiratory rhythms. We specifically discuss the possible impact of these cognitive states and autonomic rhythms on neuromodulator signaling and subsequent neuroplasticity. Altered cognitive states (arousal deficits or pain) could affect VNS intensity, while cardiorespiratory rhythms may further inform optimized timing of VNS. We propose that understanding these interactions will lead to the development of personalized state dependent VNS paradigms for TPT.

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Effects of Transcutaneous Auricular Vagus Nerve Stimulation on the P300: Do Stimulation Duration and Stimulation Type Matter?

Giraudier,

Ventura-Bort,

Weymar

2024

Brain Sciences

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Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has attracted increasing interest as a neurostimulation tool with potential applications in modulating cognitive processes such as attention and memory, possibly through the modulation of the locus–coeruleus noradrenaline system. Studies examining the P300 brain-related component as a correlate of noradrenergic activity, however, have yielded inconsistent findings, possibly due to differences in stimulation parameters, thus necessitating further investigation. In this event-related potential study involving 61 participants, therefore, we examined how changes in taVNS parameters, specifically stimulation type (interval vs. continuous stimulation) and duration, influence P300 amplitudes during a visual novelty oddball task. Although no effects of stimulation were found over the whole cluster and time window of the P300, cluster-based permutation tests revealed a distinct impact of taVNS on the P300 response for a small electrode cluster, characterized by larger amplitudes observed for easy targets (i.e., stimuli that are easily discernible from standards) following taVNS compared to sham stimulation. Notably, our findings suggested that the type of stimulation significantly modulated taVNS effects on the P300, with continuous stimulation showing larger P300 differences (taVNS vs. sham) for hard targets and standards compared to interval stimulation. We observed no interaction effects of stimulation duration on the target-related P300. While our findings align with previous research, further investigation is warranted to fully elucidate the influence of taVNS on the P300 component and its potential utility as a reliable marker for neuromodulation in this field.

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Effects of transcutaneous auricular vagus nerve stimulation on P300 magnitudes and salivary alpha-amylase during an auditory oddball task

Cited by 4 publications

References 57 publications

Processing of acoustic and phonological information of lexical tones at pre-attentive and attentive stages

Processing of acoustic and phonological information of lexical tones at pre-attentive and attentive stages

State dependent vagus nerve stimulation for targeted plasticity therapy: challenges and considerations

Effects of Transcutaneous Auricular Vagus Nerve Stimulation on the P300: Do Stimulation Duration and Stimulation Type Matter?

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