Effects of transcutaneous electrical stimulation of lower limb muscles on experimental fatty liver

El-Kafoury, Bataa; Seif, Ansam Aly; El-Hady, Enas A. El-Aziz Abd; El-Sebaiee, A E

doi:10.1016/j.ajg.2016.03.004

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…Meanwhile, combined fructose‐supplemented hyperuricemic rats, herein, exhibited more dyslipidemic effects and extensive liver injury than hyperuricemia alone, in line with Nakagawa et al () and El‐Kafoury, Abdel Rhman, and Salah El Din (). Dyslipidemia and moderate hepatic steatosis in these rats, herein, could be explained by the ability of high fructose to cause hepatic triglycerides accumulation (Tapia et al, ), and induce liver injury in mice (Han, Li, Huang, & Yang, ), through inducing a defect in the antioxidant defence mechanisms and excessive ROS production (Busserolles, Gueux, Rock, Mazur, & Rayssiguier, ), thereby causing excessive lipid peroxidation (Joyeux‐Faure, Rossini, Ribuot, & Faure, ).…”

Section: Discussionsupporting

confidence: 88%

Possible role ofl‐carnitine in improvement of metabolic and hepatic changes in hyperuricemic and hyperuricemic—Fructose‐supplemented rats

et al. 2019

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Hyperuricemia was linked to diabetes mellitus, metabolic syndrome, and oxidative stress, and could be induced by higher fructose consumption through altering energy status in liver. l‐Carnitine is an antioxidant, affecting mitochondria and cellular energetics; however, little is known about its effects in hyperuricemic states. This study investigated metabolic and hepatic effects of hyperuricemia and fructose feeding, and demonstrated the role of l‐Carnitine in such states. Fifty adult male Wistar rats were randomly divided into control, untreated hyperuricemic, fructose‐supplemented hyperuricemic, l‐Carnitine‐treated hyperuricemic, and l‐Carnitine‐treated fructose‐supplemented hyperuricemic groups. The separated plasma was used for determination of the glycemic control, lipid profile, liver function tests, uric acid level, and oxidative stress markers. Atherogenic index, HOMA‐IR, and body mass index (BMI) were calculated. Left liver lobe and left kidney specimen from all groups were used for histopathological studies. Hyperuricemic rats exhibited significantly hypoalbuminemia, dyslipidemia, insulin resistance, and oxidative stress compared to the controls. Fructose‐supplemented hyperuricemic group showed obesity and more deleterious effects, as well as, steatosis, and renal tubular damage compared to the hyperuricemic rats. Concomitant l‐Carnitine treatment with hyperuricemia improved such effects, despite causing adiposity. While combined l‐Carnitine treatment and fructose supplementation in hyperuricemia limited the aggressive hyperuricemic picture of fructose supplementation. It is concluded that hyperuricemia has detrimental metabolic and hepatic effects. Artificial fructose supplementation worsened such effects, while l‐Carnitine was efficient in ameliorating these hyperuricemia and/or excess fructose‐induced hyperuricemia effects, through its anti‐inflammatory, antisteatotic, and antioxidant properties.

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Section: Discussionsupporting

confidence: 88%

Possible role ofl‐carnitine in improvement of metabolic and hepatic changes in hyperuricemic and hyperuricemic—Fructose‐supplemented rats

et al. 2019

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“…Species specific genes used for confirmation and differentiation among Vibrio species. According to Tarr et al, 2007, V. cholera was detected by sodB gene that show light band at 248 bp and V. parahaemolyticus was identified by toxR gene that produced light band at 368 bp as mentioned by Kim et al, 1999. In our study, the occurrence of Vibrio species was found 93.3% compared to 98.67%, 82.87% and 27.7% as reported by Noorlis et al, 2011, Suresh et al, 2018and El-Hady et al, 2015 respectively, the occurrence of V. cholera was found 57.1% this result is higher than the result obtained by Asran et al, 2020 andArunagiri et al, 2016 who recorded it with percentage 3.45% and 22.4% respectively and the occurrence of V. parahaemolyticus was found `42.9% compared to 75.9%, 50% and 17.24% reported by Anjay et al, 2014, Asran et al, 2020and Arunagiri et al, 2016 This difference in prevalence percentages may be related to difference in area, fish species, change in the fish immune system and time and methods of sampling and water quality characters (Abdelaziz et al, 2017). The detection of virulence genes in each species is so important to detect the ability of the bacteria to produce the disease.…”

Section: Discussionsupporting

confidence: 65%

Microbiological and molecular characterization of Vibrio cholera and Vibrio parahaemolyticus isolated from Tilapia fish (Oreochromis niloticus

Ali

Al-Azeem

Younis

2023

SVU-International Journal of Veterinary Sciences

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Vibrio species are zoonotic pathogens that can affect humans by different routes such as ingestion or contact causing gastrointestinal diseases and wound infection. This study aimed to detect V. cholera and V. parahaemolyticus in Nile Tilapia fish collected from Aswan Governorate, Egypt. A total of 52 muscle samples were collected from Tilapia fish and were subjected to microbiological and molecular characterization. Alkaline peptone water media was used for the enrichment of the samples then followed by inoculation onto thiosulfate citrate bile salt sucrose (TCBS) agar media for the isolation of Vibrio species, biochemical tests were performed to identify V. cholera and V. parahaemolyticus, and then they were confirmed by Vibrio genus-specific gene and virulence genes by PCR . Out of 52 fish muscle samples (Nile Tilapia) 32 appeared as yellow colonies, 2 samples showed green colonies and 18 samples showed mixed yellow and green on TCBS agar. Only 40 samples show biochemically positive for Vibrio species. 15 random samples were amplified to 16srRNA gene by PCR technique for more accurate identification resulting in 14 isolates being positive to 16srRNA, 8 isolates positive for sodB gene-specific of V. cholera, and 6 isolates positive for toxR gene-specific of V. parahaemolyticus. Out of 8 V. cholera isolates were found high resistance rate to amoxiclav (87.5%), gentamicin (75%), chloramphenicol (50 %) and ampicillin (50 %). Conversely, (50 %) sensitive to tetracycline, ciprofloxacin and, trimethoprimsulphamethoxazole, and the average MRA of V. cholera was 0.48. On the other hand, all 6 V. parahaemolyticus isolates were resistant to amoxiclav (100%), tetracycline (100%), gentamicin (100%) and chloramphenicol (100%) However, all isolates sensitive to trimethoprimsulphamethazole (100%) but half of them sensitive to ciprofloxacin (50%) and ampicillin (50%), and the average MRA of V. parahaemolyticus was 0.59. In conclusion, this study showed that V. cholera is the most dominant pathogenic one then followed by V. parahaemolyticus in Nile tilapia fish resulting in economic losses and causing public health problems.

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“…0001171, CE) supplied from the physiology department. [31] By the end of the experimental duration, all animals were sacrificed. Extraction of the anal canal was done.…”

Section: Cutaneous Ano-rectal Electric Stimulationmentioning

confidence: 99%

A Study of the Effect of Cutaneous Electric Stimulation on the Structure of The Anal Sphincter of Rat After Induction of Anal Muscle Injury

Aziz,

Rizkalla,

Naguib

et al. 2024

The Egyptian Journal of Anatomy

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Background: It is well known that the muscles of the anus perform a critical role in maintaining continence. Any defect in their structure can negatively affect the physiological control of feces. Anorectal electro-stimulation, proved to improve the anal musculature. The exact effect remains unclear Aim of the work: The present work aimed to investigate the effect of cutaneous electrical stimulation upon regeneration of the injured anal sphincter in a rat. Material and Methods: 30 adult female albino rats were divided into four groups. Group I (12 rats): control group (IA) and sham group (IB). The other 3 groups (6 rats each) were subjected to anal sphincter injury. Group II: rats were subjected to anal sphincter injury. Group III: rats were left for spontaneous healing for 3 weeks. Group IV: received cutaneous anal electric stimulation for three weeks. At the end of the determined period, rats were sacrificed, specimens from the lower part of anal canal were processed for paraffin and semithin sections and stained with Haematoxylin and Eosin, Masson's trichrome, Toluidine blue and immune-histochemical stains (anti-desmin and anti alpha-SMA-antibodies). Results: Group II showed marked affection of both external and internal anal muscles. Group III showed disorganization of normal histological architecture of both anal muscles. On the other hand, group IV revealed findings indicating regeneration of the muscle fibers. Conclusion:The use of the cutaneous electric stimulation proved to be useful in muscle healing with regaining almost the normal architecture of the injured external and internal anal muscles.

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Effects of transcutaneous electrical stimulation of lower limb muscles on experimental fatty liver

Cited by 4 publications

References 44 publications

Possible role ofl‐carnitine in improvement of metabolic and hepatic changes in hyperuricemic and hyperuricemic—Fructose‐supplemented rats

Possible role ofl‐carnitine in improvement of metabolic and hepatic changes in hyperuricemic and hyperuricemic—Fructose‐supplemented rats

Microbiological and molecular characterization of Vibrio cholera and Vibrio parahaemolyticus isolated from Tilapia fish (Oreochromis niloticus

A Study of the Effect of Cutaneous Electric Stimulation on the Structure of The Anal Sphincter of Rat After Induction of Anal Muscle Injury

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