Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study

Engen, Deborah J.; McAllister, Samantha J.; Whipple, Mary O.; Stephen, S.; Dion, Liza J.; Vincent, Ann; Bauer, Brent A.; Wahner‐Roedler, Dietlind L.

doi:10.1016/s2095-4964(15)60195-9

Cited by 28 publications

(23 citation statements)

References 18 publications

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“…Furthermore, the group receiving the combination of magnesium and amitriptyline reported significantly decreased pain across various pain and tenderness index scores, while magnesium alone resulted in an improvement in the number of tender points and the intensity of fibromyalgia pain [ 53 ]. Another study reported improved scores on the Fibromyalgia Impact Questionnaire-Revised (FIQR) after 8 weeks of transdermal magnesium chloride solution use [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Magnesium in Neurological Disorders

2018

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Magnesium is well known for its diverse actions within the human body. From a neurological standpoint, magnesium plays an essential role in nerve transmission and neuromuscular conduction. It also functions in a protective role against excessive excitation that can lead to neuronal cell death (excitotoxicity), and has been implicated in multiple neurological disorders. Due to these important functions within the nervous system, magnesium is a mineral of intense interest for the potential prevention and treatment of neurological disorders. Current literature is reviewed for migraine, chronic pain, epilepsy, Alzheimer’s, Parkinson’s, and stroke, as well as the commonly comorbid conditions of anxiety and depression. Previous reviews and meta-analyses are used to set the scene for magnesium research across neurological conditions, while current research is reviewed in greater detail to update the literature and demonstrate the progress (or lack thereof) in the field. There is strong data to suggest a role for magnesium in migraine and depression, and emerging data to suggest a protective effect of magnesium for chronic pain, anxiety, and stroke. More research is needed on magnesium as an adjunct treatment in epilepsy, and to further clarify its role in Alzheimer’s and Parkinson’s. Overall, the mechanistic attributes of magnesium in neurological diseases connote the macromineral as a potential target for neurological disease prevention and treatment.

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Section: Resultsmentioning

confidence: 99%

The Role of Magnesium in Neurological Disorders

2018

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“…[23] Student's t tests for continuous variables and Rao–Scott chi-square tests for categorical variables were used to compare the differences in the number of remaining tooth with the other variables. The SAS statistical software package (version 9.3; SAS institute, Cary, NC) was used for the analysis.…”

Section: Methodsmentioning

confidence: 99%

Influence of oral health behavior and sociodemographic factors on remaining teeth in Korean adults

Song

Han

Choi³

et al. 2016

Medicine

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In this study, the number and location of remaining teeth were analyzed according to sociodemographic variables, anthropometric measurements, and oral health behavior patterns. The hypothesis was that the number and location of remaining teeth would be affected by oral health behavior and by sociodemographic factors, such as education levels, household income, and urban/rural residency.This nationwide cross-sectional study was performed with a total of 36,026 representative Korean adults aged 19 and older. The data were taken from the 2012–2012 Korea National Health and Nutrition Examination Survey.Men had, on average, significantly more remaining teeth than women did. Women brushed their teeth more often than men per day and were more likely to brush their teeth after meals. The participants with higher education levels or household income had significantly more remaining teeth; the number of daily tooth brushing was positively associated with the number of remaining teeth; urban residents had significantly more remaining teeth than rural residents; and elderly adults had fewer remaining teeth than younger adults had (all with P < 0.05). The participants were more likely to retain their incisors (especially their canines) for their entire lifetimes than do so for their molars. From the incisors to the second premolars, they had more mandibular teeth than maxillary teeth, but among molars, they had more maxillary teeth than mandibular teeth. Elementary graduates with low household income had fewer remaining teeth than did university graduates with high household income (P < 0.0001). Finally, participants with high socioeconomic status were more likely to lose their molar teeth than anterior teeth compared to those with low socioeconomic status.The participants who brushed their teeth fewer times per day, those with low household incomes and/or education levels, and those who lived in rural districts had significantly higher prevalence of tooth loss than did other groups in Korean adults. Participants had more anterior and premolar teeth on mandible, but they had more molars on maxilla. In addition, participants with high socioeconomic status were more likely to lose their molar teeth than anterior teeth compared to those with low socioeconomic status.

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“…Moreover, apart from the beneficial effects of Mg in the skin, this element, along with Ca, is also essential for good bone and muscle health. Therefore, if any of these elements are able to reach the bloodstream during the hydrogel treatment, they could also help treat other systemic musculoskeletal disorders, such as fibromyalgia [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogels

et al. 2020

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Inorganic hydrogels formulated with spring waters and clay minerals are used to treat musculoskeletal disorders and skin affections. Their underlying mechanism of action for skin disorders is not clear, although it is usually ascribed to the chemical composition of the formulation. The aim of this study was to assess the composition and in vitro release of elements with potential wound healing effects from hydrogels prepared with two nanoclays and natural spring water. In vitro Franz cell studies were used and the element concentration was measured by inductively coupled plasma techniques. Biocompatibility studies were used to evaluate the potential toxicity of the formulation against fibroblasts. The studied hydrogels released elements with known therapeutic interest in wound healing. The released ratios of some elements, such as Mg:Ca or Zn:Ca, played a significant role in the final therapeutic activity of the formulation. In particular, the proliferative activity of fibroblasts was ascribed to the release of Mn and the Zn:Ca ratio. Moreover, the importance of formulative studies is highlighted, since it is the optimal combination of the correct ingredients that makes a formulation effective.

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Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study

Cited by 28 publications

References 18 publications

The Role of Magnesium in Neurological Disorders

The Role of Magnesium in Neurological Disorders

Influence of oral health behavior and sociodemographic factors on remaining teeth in Korean adults

Correlation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogels

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