Effects of transdermal scopolamine on heart rate variability in normal subjects

Vybiral, Tomas; Bryg, Robert J.; Maddens, Michael; Bhasin, Surjit; Cronin, Simon; Boden, William E.; Lehmann, Michael H.

doi:10.1016/0002-9149(90)91038-8

Cited by 81 publications

(22 citation statements)

References 24 publications

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“…They also showed that change from the supine to the 40°upright position did not lead to an increase in LF power. Finally, Vybiral et al demonstrated that administration of the vagomimetic transdermal scopolamine led to a significant increase in LF power in supine subjects (24). These data suggest a substantial degree of similarity in the autonomic profile of the seated and supine positions and that, in both, it appears that LF power principally reflects cardiac parasympathetic modulation.…”

Section: Discussionmentioning

confidence: 97%

RR Interval Variability Is Inversely Related to Inflammatory Markers: The CARDIA Study

Sloan

McCreath

Tracey

et al. 2007

Mol Med

235

101

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Recent evidence reveals that the immune system is under the direct control of the vagus nerve via the "cholinergic anti-inflammatory pathway." Stimulation of vagus nerve activity significantly inhibits cytokine levels in animal models, and cholinergic agents inhibit cytokine release by human macrophages. Moreover, when vagus nerve activity is decreased or absent, cytokines are overproduced. Atherosclerosis is an inflammatory disease characterized by elevated levels of CRP and IL-6, but the relationship between cardiac vagal activity and cytokine levels in healthy humans is not well understood. Here we measured RR interval variability, an index of cardiac vagal modulation, and CRP and IL-6 in 757 subjects participating in a subset of the year 15 data collection in the CARDIA study of the evolution of risk factors in young adults. Univariate analysis revealed that all indices of RRV were strongly and inversely related to IL-6 (log pg/mL b = -0.08 and -0.17 for HF and LF power, P < 0.001 respectively) and CRP (log mg/L b = -0.14 and -0.26 for HF and LF power, P < 0.001 respectively) levels. In the multivariate model including gender, race, age, smoking, physical activity, SBP, BMI, and disease, the inverse relationship between RRV and inflammatory markers, although slightly attenuated, remained significant. These findings are consistent with the hypothesis that diminished descending vagal anti-inflammatory signals can allow cytokine overproduction in humans.

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Section: Discussionmentioning

confidence: 97%

RR Interval Variability Is Inversely Related to Inflammatory Markers: The CARDIA Study

Sloan

McCreath

Tracey

et al. 2007

Mol Med

235

101

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“…Furthermore, procedures that increase HRV such as β-adrenergic receptor blockade, exercise conditioning, low dose atropine, or scopolamine administration reduce mortality rates, increase VF threshold, and decrease spontaneous, exercise induced, or ischemia induced ventricular fibrillation in animal models. 15,24,26,40,[65][66][67]69,[82][83][84][108][109][110] In human studies, β-blockade increase HRV in both healthy persons and patients who have had myocardial infarction, [82][83][84] as does scopolamine. 109 Type 1C antiarrhythmic drugs decrease HRV.…”

Section: Therapeutic Implications Of Heart Rate Variability Analysismentioning

confidence: 99%

“…15,24,26,40,[65][66][67]69,[82][83][84][108][109][110] In human studies, β-blockade increase HRV in both healthy persons and patients who have had myocardial infarction, [82][83][84] as does scopolamine. 109 Type 1C antiarrhythmic drugs decrease HRV. 86,87 Scopolamine in animal models and β-blockers in both animal models and humans improve survival after myocardial infarction, whereas 1C antiarrhythmic drugs increase mortality rates; however, how these effects are related to HRV is not established.…”

Section: Therapeutic Implications Of Heart Rate Variability Analysismentioning

confidence: 99%

Heart Rate Variability: Measurement and Clinical Utility

Kleiger

Stein

Bigger

2005

Noninvasive Electrocardiol

1,060

779

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Electrocardiographic RR intervals fluctuate cyclically, modulated by ventilation, baroreflexes, and other genetic and environmental factors that are mediated through the autonomic nervous system. Short term electrocardiographic recordings (5 to 15 minutes), made under controlled conditions, e.g., lying supine or standing or tilted upright can elucidate physiologic, pharmacologic, or pathologic changes in autonomic nervous system function. Long‐term, usually 24‐hour recordings, can be used to assess autonomic nervous responses during normal daily activities in health, disease, and in response to therapeutic interventions, e.g., exercise or drugs. RR interval variability is useful for assessing risk of cardiovascular death or arrhythmic events, especially when combined with other tests, e.g., left ventricular ejection fraction or ventricular arrhythmias.

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“…It is known that beta-receptor antagonists, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers aff ect HRV and are not administered without previous testing [22][23][24][25][26] . Th e antiarrhythmics propafenone and fl ecainide reduce HRV 27 .…”

Section: Discussionmentioning

confidence: 99%

The Influence of Corticosteroids on Heart Rate Variablity in Acute Cervical Spinal Cord Injury

Krstačić

Gamberger

2016

ACC

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SUMMARY -Heart rate variability (HRV) gives information on the sympathetic-parasympathetic autonomic balance. Th e aim of the study was to analyze sympathovagal balance after acute spinal cord injury (SCI), demonstrated by linear measures in time and frequency domain of HRV and to analyze the eff ect of corticosteroids on HRV parameters in SCI. Th e study included 40 tetraplegic patients with acute SCI and 40 healthy subjects as control group. In the SCI group, 29 patients received and 11 patients did not receive corticosteroid therapy. All patients underwent 24-hour Holter monitoring for evaluation of HRV. Cardiac autonomic balance was evaluated by analysis of HRV in time and frequency domain. Sympathovagal balance (LF/HF) was signifi cantly reduced in the groups of acute SCI patients, both with and without corticosteroid therapy, as compared with controls. However, there was no statistically signifi cant diff erence between the two SCI groups (1.74 (0524) with and 1.75 (0534) without corticosteroid therapy). Th is study showed the sympathovagal balance to be altered in the acute phase of cervical spinal cord trauma. Finally, there was no eff ect of corticosteroid therapy on HRV parameters in SCI patients.

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Effects of transdermal scopolamine on heart rate variability in normal subjects

Cited by 81 publications

References 24 publications

RR Interval Variability Is Inversely Related to Inflammatory Markers: The CARDIA Study

RR Interval Variability Is Inversely Related to Inflammatory Markers: The CARDIA Study

Heart Rate Variability: Measurement and Clinical Utility

The Influence of Corticosteroids on Heart Rate Variablity in Acute Cervical Spinal Cord Injury

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