2001
DOI: 10.1093/gerona/56.5.m266
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Effects of Transdermal Testosterone on Bone and Muscle in Older Men With Low Bioavailable Testosterone Levels

Abstract: Transdermal testosterone (5 mg/d) prevented bone loss at the femoral neck, decreased body fat, and increased lean body mass in a group of healthy men over age 65 with low bioavailable testosterone levels. In addition, both testosterone and placebo groups demonstrated gains in lower extremity muscle strength, possibly due to the beneficial effects of vitamin D. Testosterone did result in a modest increase in PSA levels but resulted in no change in signs or symptoms of prostate hyperplasia.

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Cited by 406 publications
(308 citation statements)
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“…A positive correlation between the change in FM and serum testosterone was seen in the Page et al 32 study. Smaller decreases in FM are seen after 6-12 months of testosterone supplementation in older eugonadal men 35,39,48,49 and following 90 days of treatment in overweight/obese hypogonadal older men. 50 Synthetic androgens (oxandrolone, oxymetholone) are associated with greater loss of FM than is native testosterone in short-term studies.…”
Section: Testosterone and Body Compositionmentioning
confidence: 94%
See 1 more Smart Citation
“…A positive correlation between the change in FM and serum testosterone was seen in the Page et al 32 study. Smaller decreases in FM are seen after 6-12 months of testosterone supplementation in older eugonadal men 35,39,48,49 and following 90 days of treatment in overweight/obese hypogonadal older men. 50 Synthetic androgens (oxandrolone, oxymetholone) are associated with greater loss of FM than is native testosterone in short-term studies.…”
Section: Testosterone and Body Compositionmentioning
confidence: 94%
“…37 Functional correlates of this increase in muscle mass are uncertain, 38 although measures of muscle strength assessed in short-term studies do suggest benefits with treatment. [39][40][41] Dihydrotestosterone 42 and human chorionic gonadotrophin (hCG) 43 over a 3-month period have also demonstrated improvement in selected aspects of muscle strength. While the favourable changes in FFM consistently demonstrated in short-term controlled studies may have important sequelae with regard to physical functioning, to date only surrogate predictors (strength, activity) of the desired end effects (for example, independent living, prevention of falls) have been studied.…”
Section: Testosterone and Body Compositionmentioning
confidence: 99%
“…Therapies associated to testosterone and other androgenic hormone treatment favor changes in body composition, especially in lean mass gain and neuromuscular adaptation (Allan et al 2008;Schroeder et al 2004;Page et al 2005;Kenny et al 2001;Schroeder et al 2003a). However, the effects of these types of treatment are not fully understood, since their objectives, dosages and duration as well as the association with physical activity adds complexity to the data provided by the studies on this theme (Kenny et al 2000;Morley et al 2003;Snyder et al 1999;Tenover 1998).…”
Section: Introductionmentioning
confidence: 99%
“…The Fourth Korean National Health Survey has also found a prevalence ranging from 0.1% (using the classical Baumgartner definition with 2 SD cutoff) to 11.8% (using appendicular skeletal muscle mass adjusted by body weight) in the elderly women. 17 Dam et al 18 28 ] and six clinical trials [29][30][31][32][33][34] regarding the operational criterion agreement. 18,35 They found poor agreement (varying from 4.0% to 19.9% in women, evaluated by Cohen's kappa test) for the positive results of the studies.…”
Section: Discussionmentioning
confidence: 99%