2024
DOI: 10.1101/2024.12.11.628002
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Effects of transmembrane phenylalanine residues on γ-secretase-mediated Notch-1 proteolysis

Shweta R. Malvankar,
Michael S. Wolfe

Abstract: ABSTRACTγ-Secretase is a presenilin-containing intramembrane aspartyl protease complex that cleaves within the transmembrane domain (TMD) of nearly 150 substrates, with the amyloid precursor protein (APP) being the most well studied. APP cleavage by γ-secretase generates amyloid β-peptides (Aβ) that pathologically deposit in Alzheimer’s disease. APP TMD substrate undergoes initial endoproteolysis (ε-cleavage) followed by processive carboxypeptidase trimming of long Aβ intermediates in ∼tripeptide intervals. Al… Show more

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