Effects of transplantation of FGF-2-transfected MSCs and XACB on TNF-α expression with avascular necrosis of the femoral head in rabbits

Peng, Wuxun; Dong, Wentao; Zhang, Fei; Wang, Jianbo; Zhang, Jian; Wu, Jing; Wang, Lei; Ye, Chuan; Deng, Jin

doi:10.1042/bsr20180765

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…As a result, there has been an increased focus on early interventions for AVN, aimed at preservation of the native articulation [4]. Core decompression (CD) is currently the most widely accepted treatment for early-stage AVN of the FH; however, due to limited efficacy, its use has been debated [5].…”

Section: Introductionmentioning

confidence: 99%

Role of bone marrow-derived mesenchymal stem cells in treatment avascular necrosis of femoral head

Zingon¹

2022

AJBM

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Avascular necrosis (AVN) of the femoral head (FH) is a debilitating and painful disease with multiple etiologic risk factors head shows an increasing tendency and most commonly affects younger or middle-aged adults. Fifty patients (55 hips) with stage I, II or III avascular necrosis of femoral head were treated by autologous Bone marrow-derived mesenchymal stem cells injection. The patients were followed up clinically and radiologically for a minimum of 2 years at baseline, three, six, 12, and 24 months. The functional outcome was assessed in terms of Harris hip score, and disease progression was assessed radiologically by comparing the preoperative and follow-up MRI at the end of 2 years. On 2-year follow-up, there was considerable improvement in the hip function as measured by the Harris hip score (p = 0.041). On MRI, there was a decrease in the size of the lesion in group A (p = 0.03). Our findings showed that autologous Bone marrow-derived mesenchymal stem cells in avascular necrosis of femoral head is a safe and effective procedure and has better outcome.

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Section: Introductionmentioning

confidence: 99%

Role of bone marrow-derived mesenchymal stem cells in treatment avascular necrosis of femoral head

Zingon¹

2022

AJBM

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“…On the other hand, it inhibits osteogenic differentiation, thereby destroying bone tissue ( Osta et al, 2014 ). Peng et al (2018) and Peng et al (2019) combined FGF-transfected BMSCs with xenogeneic antigens of cancellous bone (XACB) to generate tissue-engineered bone (XACB/FGF/BMSCs) and implanted these BMSCs into the necrotic region of rabbits with early ONFH after CD. After 3, 6, and 12 weeks of implantation, the expression of OPG and RANKL was significantly increased in the femoral head.…”

Section: Therapeutic Applications Of Growth Factors For Osteonecrosis...mentioning

confidence: 99%

Emerging roles of growth factors in osteonecrosis of the femoral head

et al. 2022

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Osteonecrosis of the femoral head (ONFH) is a potentially disabling orthopedic condition that requires total hip arthroplasty in most late-stage cases. However, mechanisms underlying the development of ONFH remain unknown, and the therapeutic strategies remain limited. Growth factors play a crucial role in different physiological processes, including cell proliferation, invasion, metabolism, apoptosis, and stem cell differentiation. Recent studies have reported that polymorphisms of growth factor-related genes are involved in the pathogenesis of ONFH. Tissue and genetic engineering are attractive strategies for treating early-stage ONFH. In this review, we summarized dysregulated growth factor-related genes and their role in the occurrence and development of ONFH. In addition, we discussed their potential clinical applications in tissue and genetic engineering for the treatment of ONFH.

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“…It was demonstrated in a rabbit model that FGF-2-transfected MSCs in a xenogeneic antigen-cancellous bone (XACB) scaffold can improve bone regeneration. It was found that TNF-α expression was inhibited by increased FGF-2 expression, which might have triggered the improved bone regeneration response in the steroid-induced osteonecrosis rabbit model [ 98 ]. Another study used bone MSCs transfected with both VEGF and BMP-6 in conjugation with a poly lactide-co-glycolide (PLAGA) hydrogel that were implanted subcutaneously in nude mice.…”

Section: Tissue Engineering/regenerative Therapiesmentioning

confidence: 99%

Tissue Engineering Strategies for Treating Avascular Necrosis of the Femoral Head

et al. 2021

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Avascular necrosis (AVN) of the femoral head commonly leads to symptomatic osteoarthritis of the hip. In older patients, hip replacement is a viable option that restores the hip biomechanics and improves pain but in pediatric, adolescent, and young adult patients hip replacements impose significant activity limitations and the need for multiple revision surgeries with increasing risk of complication. Early detection of AVN requires a high level of suspicion as diagnostic techniques such as X-rays are not sensitive in the early stages of the disease. There are multiple etiologies that can lead to this disease. In the pediatric and adolescent population, trauma is a commonly recognized cause of AVN. The understanding of the pathophysiology of the disease is limited, adding to the challenge of devising a clinically effective treatment strategy. Surgical techniques to prevent progression of the disease and avoid total hip replacement include core decompression, vascular grafts, and use of bone-marrow derived stem cells with or without adjuncts, such as bisphosphonates and bone morphogenetic protein (BMP), all of which are partially effective only in the very early stages of the disease. Further, these strategies often only improve pain and range of motion in the short-term in some patients and do not predictably prevent progression of the disease. Tissue engineering strategies with the combined use of biomaterials, stem cells and growth factors offer a potential strategy to avoid metallic implants and surgery. Structural, bioactive biomaterial platforms could help in stabilizing the femoral head while inducing osteogenic differentiation to regenerate bone and provide angiogenic cues to concomitantly recover vasculature in the femoral head. Moreover, injectable systems that can be delivered using a minimal invasive procedure and provide mechanical support the collapsing femoral head could potentially alleviate the need for surgical interventions in the future. The present review describes the limitations of existing surgical methods and the recent advances in tissue engineering that are leading in the direction of a clinically effective, translational solution for AVN in future.

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Effects of transplantation of FGF-2-transfected MSCs and XACB on TNF-α expression with avascular necrosis of the femoral head in rabbits

Cited by 9 publications

References 17 publications

Role of bone marrow-derived mesenchymal stem cells in treatment avascular necrosis of femoral head

Role of bone marrow-derived mesenchymal stem cells in treatment avascular necrosis of femoral head

Emerging roles of growth factors in osteonecrosis of the femoral head

Tissue Engineering Strategies for Treating Avascular Necrosis of the Femoral Head

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