Effects of transradial coronary catheterization on systemic and local vascular endothelial function and inflammatory process

Latsios, George; Antonopoulos, Alexios S; Oikonomou, Evangelos; Mourouzis, Konstantinos; Giannaki, Anastasia; Papamikroulis, Aggelos; Tsiamis, Eleftherios; Papaioannou, Spyridon; Toutouzas, Kostas; Tousoulis, Dimitris

doi:10.1016/j.ijcard.2016.08.188

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…Immunohistochemistry studies of RAs report a loss of endothelial integrity post‐catheterization and optical coherence tomography (OCT) imaging of cannulated RAs demonstrates morphological deformations and intimal tears . We and other studies have reported a significant impairment of RA vasomotor function early (<24 h) post‐cannulation that involves both endothelium‐dependent and independent vasodilation.…”

Section: Introductionmentioning

confidence: 67%

“…Identified studies originally included in the qualitative synthesis had to be excluded from the quantitative synthesis due to not fulfilling the eligibility criteria. Two studies were excluded because they assessed vasomotor function of the brachial (instead of radial) artery . A previous study from our group was also excluded from further analysis as not fulfilling eligibility criteria (site and time of assessment).…”

Section: Resultsmentioning

confidence: 99%

“…Two studies were excluded because they assessed vasomotor function of the brachial (instead of radial) artery . A previous study from our group was also excluded from further analysis as not fulfilling eligibility criteria (site and time of assessment). The study by Yan et al reporting significant impairment in FMD/NMD of the catheterized right radial artery was excluded due to the inability to extract reliable summary statistics (mean ± SD).…”

Section: Resultsmentioning

confidence: 99%

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Long-term endothelial dysfunction after trans-radial catheterization: A meta-analytic approach

et al. 2017

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Section: Introductionmentioning

confidence: 67%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Long-term endothelial dysfunction after trans-radial catheterization: A meta-analytic approach

et al. 2017

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“…Use of the femoral access route in 98% of our patients may be considered an advantage [30]. Nevertheless, our study is limited by the size of the study population.…”

Section: Discussionmentioning

confidence: 99%

Serial assessment of endothelial function 1, 6, and 12 months after ST-elevation myocardial infarction

Kandhai-Ragunath¹,

Doggen

Heijden³

et al. 2018

Heart Vessels

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Knowledge about the changes in endothelial function after ST-elevation myocardial infarction (STEMI) is of substantial interest, but serial data are scarce. The aim of the present study was to noninvasively evaluate whether endothelial function, as assessed shortly after primary percutaneous coronary intervention (PPCI) for STEMI, may improve until 12-month follow-up. This prospective observational cohort study was performed in patients in the RESPONSE randomized trial who participated in a substudy and underwent noninvasive assessment of endothelial function at 1 (baseline), 6, and 12-month follow-up after treatment of a STEMI by PPCI. The reactive hyperemia peripheral artery tonometry (RH-PAT) method was used to assess endothelial function (higher RH-PAT index signifies better function). Of the 70 study participants, who were 57.4 ± 9.7 years of age, 55 (78.6%) were male and 9 (13%) had diabetes. The endothelial function deteriorated significantly during follow-up: the RH-PAT index at baseline, 6, and 12-month follow-up was 1.90 ± 0.58, 1.81 ± 0.57, and 1.69 ± 0.49, respectively (p = 0.04). Although patients were carefully treated in outpatient clinics and adequate pharmacological therapy was prescribed, we noted an increase in total cholesterol (p = 0.001), LDL cholesterol (p = 0.002), HbA1C (p = 0.054), and diastolic blood pressure (p = 0.047) However, multivariate analysis revealed that this increase in cardiovascular risk factors could not explain the observed deterioration in endothelial function. In patients with STEMI, we observed a significant deterioration in endothelial function during 12 months after PPCI that could not be explained by changes in the traditional cardiovascular risk profile.

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“…Transradial approach provides less patient discomfort and is associated with shorter hospitalization duration. Unfortunately, occasional difficulty in accessing the radial artery, mechanical injury of vascular access site and temporary endothelial dysfunction, may lead to radial artery spasm and increase patient discomfort. Thus, successful transradial coronary catheterization depends on the provision of adequate local anaesthesia which minimizes patient discomfort and facilitates radial artery puncture, which might be particularly important in certain sub‐populations, such as lean subjects …”

Section: Discussionmentioning

confidence: 99%

Anesthetic ointment only (lidocaine/prilocaine) instead of injectable local lidocaine in trans‐radial catheterization: A viable no‐needle alternative

Latsios

Toutouzas

Antonopoulos

et al. 2017

J Interven Cardiology

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Pain levels measured by VAS were found to be similar between the two groups during sheath insertion (VAS: AO: 4.84 ± 1.0 vs 4.82 ± 1.2, P = NS), as well as 30 min after sheath removal (VAS: AO: 0.07 ± 0.5 vs LA: 0.15 ± 0.6, P = NS). The time to obtain radial access was also not affected by the use of anesthetic ointment (AO: 62.24 ± 25.7 s vs LA: 64.04 ± 18.78 sec, P = NS). The rate of clinical or angiographic radial artery spasm was similar (8-10%) between the groups (P = NS) CONCLUSION: Use of a local anesthetic ointment, versus injectable lidocaine, in trans-radial cardiac catheterization as means of local anesthesia, was found to be equally effective in terms of pain, artery spasm, or artery cannulation speed.

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Effects of transradial coronary catheterization on systemic and local vascular endothelial function and inflammatory process

Cited by 6 publications

References 9 publications

Long-term endothelial dysfunction after trans-radial catheterization: A meta-analytic approach

Long-term endothelial dysfunction after trans-radial catheterization: A meta-analytic approach

Serial assessment of endothelial function 1, 6, and 12 months after ST-elevation myocardial infarction

Anesthetic ointment only (lidocaine/prilocaine) instead of injectable local lidocaine in trans‐radial catheterization: A viable no‐needle alternative

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