Effects of Treadmill Exercise on Motor and Cognitive Function Recovery of MCAO Mice Through the Caveolin-1/VEGF Signaling Pathway in Ischemic Penumbra

Chen, Zhenzhen; Hu, Quan; Xie, Qipeng; Wu, Shamin; Pang, Qiongyi; Liu, Meixia; Zhao, Yun; Tu, Fengxia; Liu, Chan; Chen, Xiang

doi:10.1007/s11064-019-02728-1

Cited by 42 publications

(35 citation statements)

References 59 publications

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“…We further demonstrated that lower-intensity treadmill exercise not only enhances motor recovery but also increases BrdU/NeuN-double positive cells, which suggests that it might promote the differentiation or survival of newly generated neurons. These results are consistent with previous studies (Chen et al, 2019;Farioli-Vecchioli et al, 2014;Jiang, Gu, Brannstrom, Rosqvist, & Wester, 2001). In contrast, higher-intensity treadmill or wheel running exercises increased BrdU/Sox2-double positive cells, but decreased BrdU/NeuN-double positive cells, suggesting that the differentiation of newly generated neural stem cells could be perturbed by those exercises.…”

Section: F I G U R Esupporting

confidence: 94%

“…In contrast, higher‐intensity treadmill or wheel running exercises increased BrdU/Sox2‐double positive cells, but decreased BrdU/NeuN‐double positive cells, suggesting that the differentiation of newly generated neural stem cells could be perturbed by those exercises. To the best of our knowledge, the effect of exercise has been reported previously to either promote or inhibit adult neurogenesis based on other ischemic and hemorrhagic stroke models induced by MCAO or endothelin‐1 injection methods (Chen et al, ; Jiang et al, ; Leasure & Grider, ; Shimada et al, ). In the present study, we proposed that exercise could differentially affect the generation of new cells and differentiation.…”

Section: Discussionmentioning

confidence: 95%

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Different exercises can modulate the differentiation/maturation of neural stem/progenitor cells after photochemically induced focal cerebral infarction

et al. 2020

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Introduction Exercise therapies during rehabilitation significantly promote recovery from various deficits after cerebral infarction, which is mediated by neuronal plasticity with distinct inputs. Although adult neurogenesis can also be modulated by neuronal activity before synaptogenesis, how distinct exercises contribute to the neurological reorganization of the injured cerebral cortex remains unclear. In the present study, we aimed to elucidate the effects of different exercise therapies on motor recovery and neuronal reorganization after photochemically induced focal cerebral infarction. Methods Here, we examined the effects of three different exercises—(a) forced lower‐intensity and (b) higher‐intensity treadmill exercises, and (c) voluntary exercise with wheel running—on motor recovery and adult neurogenesis in a rat model of focal cerebral infarction. Photochemically induced thrombosis (PIT) was used to generate focal infarction in rats that was mostly confined to their motor cortices. Results Beam walking tests showed that recovery after PIT‐induced cortical infarction differed in acute and chronic stages and was influenced by the type of exercise. Furthermore, forced low‐intensity training had more positive effects on functional recovery than other exercises or control. To evaluate the production of newly generated cells including de novo neurogenesis, we performed lineage analysis with BrdU labeling and immunofluorescence experiments. Lower‐intensity treadmill exercise increased the number of BrdU/NeuN colabeled cells, but not total BrdU‐retaining or BrdU/Sox2‐colabeled cells, in the peri‐infarct region of the ipsilateral cortex. In contrast, high‐intensity treadmill or voluntary exercises had the opposite effects. Conclusions These results suggest that neuronal maturation can be differently modulated by distinct exercises and that low‐intensity treadmill exercise could result in more potent generation of mature neurons. This also suggests the possibility that the generation of neural stem/progenitor cells and differentiation might be modulated by rehabilitation‐mediated neural plasticity.

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Section: F I G U R Esupporting

confidence: 94%

Section: Discussionmentioning

confidence: 95%

Different exercises can modulate the differentiation/maturation of neural stem/progenitor cells after photochemically induced focal cerebral infarction

et al. 2020

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“…Angiogenesis is essential for neural recovery after ischemic stroke. A recent study by Chen et al [74] found that exercise improves angiogenesis through the caveolin-1/VEGF pathway. Taken together, BBB permeability, cell survival, inflammation, and angiogenesis are involved in the regulation of ischemic stroke by caveolin.…”

Section: Caveolin and Strokementioning

confidence: 99%

Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review

Tian¹,

Popal²,

Huang³

et al. 2020

Aging and disease

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Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.

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“…In fact, CAV1 regulates the blood-brain barrier (BBB) permeability through modifying matrix metalloproteinases' (MMP) activity responsible for ECM destructuring [131]. CAV1 decreased cerebral infarct volume, facilitated angiogenesis and neurogenesis, and promoted neurological recovery by upregulating the VEGF signaling pathway in models of middle cerebral artery occlusion [132]. CAV1 expression is regulated by cystatin C during the maintenance of BBB integrity after ischemic brain injury.…”

Section: Role Of Caveolin-1 In Oxidative Stressmentioning

confidence: 99%

Role of Caveolin-1 in Diabetes and Its Complications

Haddad

Madhoun

Nizam

et al. 2020

Oxidative Medicine and Cellular Longevity

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It is estimated that in 2017 there were 451 million people with diabetes worldwide. These figures are expected to increase to 693 million by 2045; thus, innovative preventative programs and treatments are a necessity to fight this escalating pandemic disorder. Caveolin-1 (CAV1), an integral membrane protein, is the principal component of caveolae in membranes and is involved in multiple cellular functions such as endocytosis, cholesterol homeostasis, signal transduction, and mechanoprotection. Previous studies demonstrated that CAV1 is critical for insulin receptor-mediated signaling, insulin secretion, and potentially the development of insulin resistance. Here, we summarize the recent progress on the role of CAV1 in diabetes and diabetic complications.

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Effects of Treadmill Exercise on Motor and Cognitive Function Recovery of MCAO Mice Through the Caveolin-1/VEGF Signaling Pathway in Ischemic Penumbra

Cited by 42 publications

References 59 publications

Different exercises can modulate the differentiation/maturation of neural stem/progenitor cells after photochemically induced focal cerebral infarction

Different exercises can modulate the differentiation/maturation of neural stem/progenitor cells after photochemically induced focal cerebral infarction

Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review

Role of Caveolin-1 in Diabetes and Its Complications

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