Effects of treadmill exercise on the expression of netrin-1 and its receptors in rat brain after cerebral ischemia

Liu, N; Huang, Huan; Lin, Fan; Chen, A; Zhang, Y; Chen, R; Du, Houwei

doi:10.1016/j.neuroscience.2011.07.037

Cited by 33 publications

(40 citation statements)

References 48 publications

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“…Poststroke exercise and EE also increase expression of growth-associated proteins such as growth-associated protein 43 [49], microtubule-associated protein 2 [44], and netrin (along with the associated deleted in colorectal cancer receptor) [50], as well as markers of synaptogenesis [46,51,52]. Such proteins are involved in axonal sprouting, dendritic complexity, and spine growth [4], phenomena occurring in the peri-and contralesional cortex of functionally recovered animals [14,53].…”

Section: How Do Exercise and Enrichment Enhance Plasticity And Recovery?mentioning

confidence: 99%

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery

et al. 2016

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Improved stroke care has resulted in greater survival, but >50 % of patients have chronic disabilities and 33 % are institutionalized. While stroke rehabilitation is helpful, recovery is limited and the most significant gains occur in the first 2-3 months. Stroke triggers an early wave of gene and protein changes, many of which are potentially beneficial for recovery. It is likely that these molecular changes are what subserve spontaneous recovery. Two interventions, aerobic exercise and environmental enrichment, have pleiotropic actions that influence many of the same molecular changes associated with stroke injury and subsequent spontaneous recovery. Enrichment paradigms have been used for decades in adult and neonatal animal models of brain injury and are now being adapted for use in the clinic. Aerobic exercise enhances motor recovery and helps reduce depression after stroke. While exercise attenuates many of the signs associated with normal aging (e.g., hippocampal atrophy), its ability to reverse cognitive impairments subsequent to stroke is less evident. It may be that stroke, like other diseases such as cancer, needs to use multimodal treatments that augment complimentary neurorestorative processes.

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Section: How Do Exercise and Enrichment Enhance Plasticity And Recovery?mentioning

confidence: 99%

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery

et al. 2016

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“…In rats subjected to MCAO, netrin-1 and UNC5B are expressed in neuronal perikarya in the peri-infarct area, and DCC is expressed in perivascular astrocytes [70] . In a similar study, netrin-1 was reported to be expressed in neurons in the peri-infarct region, DCC in neurons and astrocytes, and neogenin in ECs in the infarct area [71] .…”

Section: Ischemiamentioning

confidence: 99%

“…Wu et al [14] reported that the presence of netrin-1 decreases the infarct size and the number of apoptotic neurons in MCAO mice, suggesting that it has protective effects after cerebral ischemia. Liu et al [70] showed that netrin-1 and its receptors may be involved in remodeling the peri-infarct neuronal circuitry after treadmill exercise, suggesting that exercise encourages neuronal survival in the infarct region by regulating the netrin-1/UNC5B signaling pathways.…”

Section: Ischemiamentioning

confidence: 99%

Axon guidance factor netrin-1 and its receptors regulate angiogenesis after cerebral ischemia

Ding

Liao

2014

Neurosci. Bull.

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Neurogenesis and angiogenesis play important roles in functional recovery after ischemic stroke. When cerebral ischemia occurs, axon regeneration can compensate for the loss of apoptotic neurons in the ischemic area. The formation of new blood vessels ameliorates the local decrease in blood supply, enhancing the supply of oxygen and nutrients to newly-formed neurons. New blood vessels also act as a scaffold for the migration of neuroblasts to the infarct area after ischemic stroke. In light of this, researchers have been actively searching for methods to treat cerebral infarction. Netrins were fi rst identifi ed as a family of proteins that mediate axon guidance and direct axon migration during embryogenesis. Later studies have revealed other functions of this protein family. In this review, we focus on netrin-1, which has been shown to be involved in axon migration and angiogenesis, which are required for recovery after cerebral ischemia. Thus, therapies targeting netrin-1 may be useful for the treatment of ischemic stroke.

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“…The exercises after MCAO (DI) and after the sham operation (DC) lasted 6 weeks and the rats exercised for 30 min/day, on the treadmill without inclination, 5 days per week, with a speed of 12 m/min (Liu et al, 2011;Zhang et al 2012a;2012b). The exercise speed was gradually increased: On the first day the rats ran with a speed 8 m/min, on the second day at 10 m/min and on the third day at 12 m/min (Liu et al, 2011;Zhang et al 2012a;2012b).…”

Section: Physical Trainingmentioning

confidence: 99%

“…It also promotes the remodeling of synapses in the hippocampus (Liu et al, 2011). Astrocytes play an important role in this process (Humm et al, 1998;Taskapiliogly et al, 2009) by synthesizing glial-derived neurotrophic factor, which is responsible for the increased survival of dopaminergic neurons and by promoting neuroplasticity (Senna et al, 2011;Henderson et al, 1994;Lin et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Effect of Exercise Prior or After Ischemia on the Density of Neurons and Astrocytes in the Brain of Rats

Damázio¹,

Melo²,

Lima³

et al. 2014

American Journal of Neuroscience

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The aim of this study was to analyse the density of astrocytes and neurons in the motor areas of the cortex, striatum and hippocampus of rats that performed exercise before or after cerebral ischemia. A total of 36 Wistar rats were separated into two groups: One that was subjected to Middle Cerebral Artery Occlusion (MCAO) and the other that underwent surgical access in the absence of ischemia. Both groups were subdivided into: Animals that underwent exercise prior to MCAO and sham surgery (AI and AC, n = 12); animals that underwent exercise after MCAO and sham surgery (DI and DC, n = 12); and animals that did not undergo exercise (SI and SC, n = 12). The brains of mice were sectioned and stained by the Nissl method for staining of neurons and the astrocytes were labeled by immunohistochemistry with glial fibrillary acidic protein. Physical training was conducted after the surgery for 6 weeks (30 min/day), 5 days per week. The animals exercised before cerebral ischemia showed greater density of neurons in the striatum, in the apex of the dentate gyrus of the hippocampus, in the motor cortex contra lateral to the lesion and more astrocytes in the motor cortex of the cerebral hemispheres compared with the untrained group (p<0.05). The density of neurons in the brain regions analysed remained unchanged in exercised animals from the fourth day after cerebral ischemia when compared with the sedentary group.

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Effects of treadmill exercise on the expression of netrin-1 and its receptors in rat brain after cerebral ischemia

Cited by 33 publications

References 48 publications

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery

Axon guidance factor netrin-1 and its receptors regulate angiogenesis after cerebral ischemia

Effect of Exercise Prior or After Ischemia on the Density of Neurons and Astrocytes in the Brain of Rats

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