Effects of Treatment Adherence on Quality of Life in Hypoparathyroid Patients

Abstract

Objectives This study aimed to evaluate the current situation of hypoparathyroid patients and to investigate the relationship between treatment adherence and quality of life. Study design Prospective, multicentre study. Methods Adult patients presenting with the diagnosis of hypoparathyroidism to 20 different endocrinology clinics were included. They were receiving conventional therapies for hypoparathyroidism, using calcium, active vitamin D, and magnesium. We collected data on demographic features, disease- and treatment-related information, and results of routine laboratory tests, treatment adherence, and presence of complications. Beck Depression Inventory, Beck Anxiety Inventory, and Short Form-36 quality of life assessments were administered. Results Among the 300 patients studied, 60.7% were adherent to their treatment, and 34.1% had complications. Anxiety and depression scores were significantly higher in non-adherent versus treatment-adherent patients (p<0.001 and p=0.001, respectively). Most of the domains of quality-of-life scores were also significantly lower in non-adherent patients. Both anxiety and depression scores showed significant, negative correlations with serum calcium and magnesium concentrations (r=−0.336, p<0.001 and r=−0.258, p<0.001, respectively). Conclusions Nearly 40% of the patients were non-adherent to conventional treatment for hypoparathyroidism, and such patients had higher anxiety and depression scores and poorer quality of life scores. Conventional treatment might not be sufficient to meet the needs of patients with hypoparathyroidism. In addition to seeking new therapeutic options, factors influencing quality of life should also be investigated and strategies to improve treatment adherence should be developed.

[Retracted] Effect of New Nursing Team Management Mode on Self‐Efficacy, Compliance, and Quality of Life of Patients with Chronic Kidney Disease and Its Chain Mediating Effect

“…The observation indicators are divided into the following steps: (1) General Self-efficacy Scale (GSES) is used at all 4 time points to evaluate the patients' self-efficacy. The full score was 40, and self-efficacy increased with the increase of the score; (2) the patient's adherence is evaluated according to the Morisky Medication Adherence Scale (MMAS-8) [ 15 ]. The first seven adherence items all contain yes and no, each of which is scored in accordance with 0∼1 points.…”

Biochemical Control of 78 Patients with Chronic Hypoparathyroidism Referred between 2006 and 2020 – Where do We Actually Stand?

“…Calcitriol has actually been linked to declining renal function and risk for polyuria and nephrolithiasis [22][23][24][25]. Coming back to poor biochemical control of our patients, one must keep in mind that it is clearly linked to a higher risk for complications and worse quality of life as reported elsewhere [25][26][27].…”

Quality of life, social support, and adherence in female patients with thyroid disorders

“…The Morisky Medication Adherence Scales measure patients' cooperation (adherence) in their medication (55).…”

“…Moreover, hormone levels should be carefully monitored, which requires cooperation from the patient. Therefore, it is important to inform patients about their health status to ensure adherence (33,54,55). Indeed, a recent study has shown that non-adherent thyroid patients reported more symptoms of depression, anxiety, and poorer quality of life (55).…”

“…Therefore, it is important to inform patients about their health status to ensure adherence (33,54,55). Indeed, a recent study has shown that non-adherent thyroid patients reported more symptoms of depression, anxiety, and poorer quality of life (55). Overall, evidence suggests that adherence to treatment is associated with improved mental health.…”